Výsledky vyhledávání - "Leonardo S, Novaes"

Akademický článek

Genomic glucocorticoid receptor effects guide acute stress-induced delayed anxiety and basolateral amygdala spine plasticity in rats

Autor: Leonardo S. Novaes, Leticia M. Bueno-de-Camargo, Amadeu Shigeo-de-Almeida, Vitor A.L. Juliano, Ki Goosens, Carolina D. Munhoz

Publikováno v: Neurobiology of Stress, Vol 28, Iss , Pp 100587- (2024)

Anxiety, a state related to anticipatory fear, can be adaptive in the face of environmental threats or stressors. However, anxiety can also become persistent and manifest as anxiety- and stress-related disorders, such as generalized anxiety or post-t

Externí odkaz: https://doaj.org/article/08cae7bfad6e4841a24ec2039615313c

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Akademický článek

Effects of Bradykinin B2 Receptor Ablation from Tyrosine Hydroxylase Cells on Behavioral and Motor Aspects in Male and Female Mice

Autor: Thaina Maquedo Franco, Mariana R. Tavares, Leonardo S. Novaes, Carolina D. Munhoz, Jose Eduardo Peixoto-Santos, Ronaldo C. Araujo, Jose Donato, Michael Bader, Frederick Wasinski

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 3, p 1490 (2024)

The kallikrein–kinin system is a versatile regulatory network implicated in various biological processes encompassing inflammation, nociception, blood pressure control, and central nervous system functions. Its physiological impact is mediated thro

Externí odkaz: https://doaj.org/article/b9c7c1da98f34778b44ce5c93c176fa0

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How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders

Autor: Louise F. Kimura, Leonardo S. Novaes, Gisele Picolo, Rosana Camarini, Carolina Demarchi Munhoz, Chi W. Cheung

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Depression and anxiety commonly occur in chronic pain states and the coexistence of these diseases worsens outcomes for both disorders and may reduce treatment adherence and response. Despite the advances in the knowledge of chronic pain mechanisms,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9707cd2a2f412b037e4d331935e0694f
https://doi.org/10.1111/bph.15584

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Environmental enrichment prevents the late effect of acute stress-induced fear extinction deficit: the role of hippocampal AMPA-GluA1 phosphorylation

Autor: Letícia Morais Bueno-de-Camargo, Leonardo S. Novaes, Carolina Demarchi Munhoz

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The persistence of anxiety and the deficit of fear memory extinction are both phenomena related to the symptoms of a trauma-related disorder, such as post-traumatic stress disorder (PTSD). Recently we have shown that single acute restraint stress (2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423547f23ec24f5bce5201c8192ff4b0
https://doaj.org/article/ff77485ea0ba4e98a7019cefcb8f4109

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Oxidative Stress Inhibition Via Apocynin Prevents Medullary Respiratory Neurodegeneration and Respiratory Pattern Dysfunction in a 6-Hydroxydopamine Animal Model of Parkinson's Disease

Autor: André L.F. Nascimento, Pamela O.S. Medeiros, Luiz F.A.T. Pedrão, Vitoria C. Queiroz, Luiz M. Oliveira, Leonardo S. Novaes, Ariadiny L. Caetano, Carolina D. Munhoz, Ana C. Takakura, Barbara Falquetto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Parkinson's Disease (PD) is a neurogenerative disorder characterized by the death of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc), leading to motor, cognitive, learning, and respiratory dysfunctions. New evidence revealed that br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f34dbf85b78b9bbc96c62091795942
https://pubmed.ncbi.nlm.nih.gov/35934251

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Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation

Autor: Marilia B, Malta, Joelcimar, Martins, Leonardo S, Novaes, Nilton B, Dos Santos, Luciane, Sita, Rosana, Camarini, Cristoforo, Scavone, Jackson, Bittencourt, Carolina D, Munhoz

Publikováno v: Molecular neurobiology. 58(10)

The stress response is multifactorial and enrolls circuitries to build a coordinated reaction, leading to behavioral, endocrine, and autonomic changes. These changes are mainly related to the hypothalamus-pituitary-adrenal (HPA) axis activation and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24e451999359ac1f469056337513fba6
https://pubmed.ncbi.nlm.nih.gov/34213722

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Norepinephrine and glucocorticoids modulate chronic unpredictable stress-induced increase in the Type 2 CRF and glucocorticoid receptors in brain structures related to the HPA Axis activation

Autor: Joelcimar Martins, Jackson C. Bittencourt, M. B. Malta, Carolina Demarchi Munhoz, Rosana Camarini, Cristoforo Scavone, Luciane V. Sita, Leonardo S. Novaes, Nilton Barreto dos Santos

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c9332b38aaafdfe22b57ca07c4cf17

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High dose of dexamethasone protects against EAE-induced motor deficits but impairs learning/memory in C57BL/6 mice

Autor: Carolina Demarchi Munhoz, Guilherme Dragunas, Jennifer R Rodrigues, Leonardo S. Novaes, Jean Pierre Schatzmann Peron, Nilton Nascimento Dos Santos, Rosana Camarini, Wesley Nogueira Brandão

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, 9(1). Nature Publishing Group
Scientific Reports

Multiple sclerosis (MS) is an autoimmune and neuroinflammatory disease characterized by demyelination of the Central Nervous System. Immune cells activation and release of pro-inflammatory cytokines play a crucial role in the disease modulation, deci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a122c44b4eb1f4abac21a6b95edab0
https://doi.org/10.1038/s41598-019-43217-3

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Repeated Restraint Stress Decreases Na,K-ATPase Activity via Oxidative and Nitrosative Damage in the Frontal Cortex of Rats

Autor: Juliano Genaro Perfetto, Cristoforo Scavone, Juan C. Leza, Carolina Demarchi Munhoz, Nilton Barreto dos Santos, Leonardo S. Novaes, Guilherme Dragunas

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Chronic psychogenic stress can increase neuronal calcium influx and generate the intracellular accumulation of oxidative (ROS) and nitrosative (RNS) reactive species, disrupting synaptic transmission in the brain. These molecules impair the Na,K-ATPa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001751af8ae58ac5ce97b9a1a54537b2
https://pubmed.ncbi.nlm.nih.gov/30316912

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