Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Leonardo R. Andrade"'
Autor:
Manasi Iyer, Husniye Kantarci, Madeline H. Cooper, Nicholas Ambiel, Sammy Weiser Novak, Leonardo R. Andrade, Mable Lam, Graham Jones, Alexandra E. Münch, Xinzhu Yu, Baljit S. Khakh, Uri Manor, J. Bradley Zuchero
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Myelin is essential for rapid nerve signaling and is increasingly found to play important roles in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as sheath length are thought to precisely tune conduction
Externí odkaz:
https://doaj.org/article/edb4db5ca7254451a2a567b2d539c96f
Autor:
Ely Cheikh Boussaty, Yuzuru Ninoyu, Leonardo R Andrade, Qingzhong Li, Ryu Takeya, Hideki Sumimoto, Takahiro Ohyama, Karl J Wahlin, Uri Manor, Rick A Friedman
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011211 (2024)
Age-related hearing loss (ARHL) is a common sensory impairment with complex underlying mechanisms. In our previous study, we performed a meta-analysis of genome-wide association studies (GWAS) in mice and identified a novel locus on chromosome 18 ass
Externí odkaz:
https://doaj.org/article/ac94d3baa66a4707867124f7352245ec
Autor:
Shahar Taiber, Oren Gozlan, Roie Cohen, Leonardo R. Andrade, Ellen F. Gregory, Daniel A. Starr, Yehu Moran, Rebecca Hipp, Matthew W. Kelley, Uri Manor, David Sprinzak, Karen B. Avraham
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Nuclear positioning is important for the functionality of many cell types and is mediated by interactions of cytoskeletal elements and nucleoskeleton proteins. Nesprin proteins, part of the linker of nucleoskeleton and cytoskeleton (LINC) complex, ha
Externí odkaz:
https://doaj.org/article/c4bbcbe3a3a34baaae5077c63b081c52
Autor:
Miguel A. Ramirez, Yuzuru Ninoyu, Cayla Miller, Leonardo R. Andrade, Seby Edassery, Ewa Bomba-Warczak, Briana Ortega, Uri Manor, Mark A. Rutherford, Rick A. Friedman, Jeffrey N. Savas
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104803- (2022)
Summary: Hearing depends on precise synaptic transmission between cochlear inner hair cells and spiral ganglion neurons through afferent ribbon synapses.Neuroligins (Nlgns) facilitate synapse maturation in the brain, but they have gone unstudied in t
Externí odkaz:
https://doaj.org/article/2d83c1d5d98a4ed9a50479488748c93e
Autor:
Manasi Iyer, Husniye Kantarci, Nicholas Ambiel, Sammy W. Novak, Leonardo R. Andrade, Mable Lam, Alexandra E. Münch, Xinzhu Yu, Baljit S. Khakh, Uri Manor, J. Bradley Zuchero
Publikováno v:
bioRxiv
SUMMARYMyelin is essential for rapid nerve signaling and is increasingly found to play important roles in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as sheath length and thickness are regulated by neuronal ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d523db210094da0f5920577c6360e6
https://europepmc.org/articles/PMC10120717/
https://europepmc.org/articles/PMC10120717/
Autor:
Tai Chaiamarit, Adriaan Verhelle, Romain Chassefeyre, Nandini Shukla, Sammy Weiser Novak, Leonardo R. Andrade, Uri Manor, Sandra E. Encalada
Publikováno v:
bioRxiv
Dystrophic axons comprising misfolded mutant prion protein (PrP) aggregates are a characteristic pathological feature in the prionopathies. These aggregates form inside endolysosomes -called endoggresomes-, within swellings that line up the length of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb4414756a708c4cc4a835bf1e2ebd7
https://europepmc.org/articles/PMC10055262/
https://europepmc.org/articles/PMC10055262/
Autor:
Cristiano C Coutinho, Ivone de Andrade Rosa, John Douglas de Oliveira Teixeira, Leonardo R Andrade, Manoel Luis Costa, Claudia Mermelstein
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178350 (2017)
Sponges have a high capacity for regeneration and this process improves biomass production in some species, thus contributing to a solution for the biomass supply problem for biotechnological applications. The aim of this work is to characterize the
Externí odkaz:
https://doaj.org/article/ce116252be81469388eab0d005cdaf67
Autor:
Gerald S. Shadel, J. Silvio Gutkind, Rachael E Schwartz, Leonardo R. Andrade, Maxim N. Shokhirev, Ramiro Iglesias-Bartolome
Publikováno v:
Aging (Albany NY)
Senescent cells produce chronic inflammation that contributes to the diseases and debilities of aging. How this process is orchestrated in epithelial cells, the origin of human carcinomas, is poorly understood. We used human normal oral keratinocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd02d5011cfd7556fb3525095f869e5
https://doi.org/10.18632/aging.202658
https://doi.org/10.18632/aging.202658
Autor:
Omar A. Quintero, Tsung-Chang Sung, Pauline Wales, Andrew S. Moore, Tong Zhang, Bing Zhao, Gerald S. Shadel, Uri Manor, Robert Grosse, Melissa Wu, Yelena Dayn, Cara R. Schiavon, Jasmine W. Feng, Leonardo R. Andrade
Publikováno v:
Nat Methods
The actin cytoskeleton plays multiple critical roles in cells, from cell migration to organelle dynamics. The small and transient actin structures regulating organelle dynamics are difficult to detect with fluorescence microscopy, and the limited res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9530d0c8740d45dccd95b98a137158be
https://doi.org/10.1038/s41592-020-0926-5
https://doi.org/10.1038/s41592-020-0926-5
Autor:
Larissa G P Langhi, Leonardo R Andrade, Marilia Kimie Shimabukuro, Willem van Ewijk, Dennis D Taub, Radovan Borojevic, Valeria de Mello Coelho
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141516 (2015)
Intrathymic lipid-laden multilocular cells (LLMC) are known to express pro-inflammatory factors that might regulate functional activity of the thymus. However, the phenotype of age-associated intrathymic LLMC is still controversial. In this study, we
Externí odkaz:
https://doaj.org/article/4313fc4ebc7142328472dbe3d8b1283b