HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling

Autor: Leonardo Pedrazza, Arturo Martinez-Martinez, Cristina Sánchez-de-Diego, José Antonio Valer, Carolina Pimenta-Lopes, Joan Sala-Gaston, Michal Szpak, Chris Tyler-Smith, Francesc Ventura, Jose Luis Rosa

Publikováno v: Cell Death and Disease, Vol 14, Iss 1, Pp 1-11 (2023)

Abstract Bone remodeling is a continuous process between bone-forming osteoblasts and bone-resorbing osteoclasts, with any imbalance resulting in metabolic bone disease, including osteopenia. The HERC1 gene encodes an E3 ubiquitin ligase that affects

Externí odkaz: https://doaj.org/article/f69084f257f242148b7db2221e14ea63

Mesenchymal stem cells decrease lung inflammation during sepsis, acting through inhibition of the MAPK pathway

Autor: Leonardo Pedrazza, Monica Cubillos-Rojas, Fernanda Cristina de Mesquita, Carolina Luft, Aline Andrea Cunha, Jose Luis Rosa, Jarbas Rodrigues de Oliveira

Publikováno v: Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-14 (2017)

Abstract Background Sepsis is a severe medical condition that ranks among the top 10 causes of death worldwide and which has permanently high incidence rates. Mesenchymal stem cells (MSCs) have been found to be potent modulators of immune responses.

Externí odkaz: https://doaj.org/article/880d1c0714924525866d0c323cf8b3f6

Gestational stress alters maternal behavior and inflammatory markers in the olfactory bulb of lactating mice

Autor: Márcio Vinícius Fagundes Donadio, Rodrigo Grassi-Oliveira, Luis Eduardo Wearick-Silva, Carolina Luft, Jarbas Rodrigues de Oliveira, Géssica Luana Antunes, Mariana Severo da Costa, Leonardo Pedrazza

Publikováno v: International Journal of Developmental Neuroscience. 82:180-187

Inflammatory markers represent important candidates responsible for the altered behavior and physiology observed after stressful experiences. In the maternal brain, the olfactory bulb (OB) is a key constituent of the neural circuit that mediates the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653cf53b3ad15c34b66e4f3508e34f83
https://doi.org/10.1002/jdn.10156

HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress

Autor: Joan Sala-Gaston, Leonardo Pedrazza, Juanma Ramirez, Arturo Martinez-Martinez, Lettie E. Rawlins, Emma L. Baple, Andrew H. Crosby, Ugo Mayor, Francesc Ventura, Jose Luis Rosa

HERC2 gene encodes an E3 ubiquitin ligase involved in several cellular processes by regulating the ubiquitylation of different protein substrates. Biallelic pathogenic sequence variants in the HERC2 gene are associated with HERC2 Angelman-like syndro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246e2e141f3466c5706349bb44dc56e2
https://doi.org/10.21203/rs.3.rs-1600424/v1

HERC Ubiquitin Ligases in Cancer

Autor: Joan Sala-Gaston, Xosé R. Bustelo, Arturo Martinez-Martinez, Jose Luis Rosa, L. Francisco Lorenzo-Martín, Ruben Caloto, Francesc Ventura, Leonardo Pedrazza

Publikováno v: Cancers, Vol 12, Iss 1653, p 1653 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Cancers

© 2020 by the authors.
HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is composed of six members classified by size into large (HERC1 and HERC2) and small (HERC3–HERC6). HERC family ubiquitin ligases regulate im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e140596367dbe8c5ede34ebd654325
https://www.mdpi.com/2072-6694/12/6/1653