Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Leonardo Nimrichter"'
Autor:
Leandro Honorato, Jhon J. Artunduaga Bonilla, Alessandro F. Valdez, Susana Frases, Glauber Ribeiro de Sousa Araújo, Albaniza Liuane Ribeiro do Nascimento Sabino, Natalia Martins da Silva, Larissa Ribeiro, Marina da Silva Ferreira, Julio Kornetz, Marcio L. Rodrigues, Iain Cunningham, Neil A. R. Gow, Attila Gacser, Allan J. Guimarães, Fabianno F. Dutra, Leonardo Nimrichter
Publikováno v:
mSphere, Vol 9, Iss 8 (2024)
ABSTRACT Systemic candidiasis remains a significant public health concern worldwide, with high mortality rates despite available antifungal drugs. Drug-resistant strains add to the urgency for alternative therapies. In this context, vaccination has r
Externí odkaz:
https://doaj.org/article/1dc59086ea434c24bf763a412b238806
Autor:
Elaine C. Albergoni, Haroldo C. Oliveira, Leandro Honorato, Alessandro F. Valdez, Bianca G. Sena, Rafael F. Castelli, Ana Julia Curioni Rodrigues, Bruna H. Marcon, Anny W. Robert, Leonardo Nimrichter, Marcio L. Rodrigues
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Emergomyces africanus is a highly fatal fungal pathogen affecting individuals with advanced HIV disease. Molecular patterns and ultrastructural aspects of E. africanus are unknown, and pathogenic models have not been investigated in detail.
Externí odkaz:
https://doaj.org/article/590cbaad16214f399ba160e8f787f57f
Autor:
Leandro Honorato, Jhon Jhamilton Artunduaga Bonilla, Larissa Ribeiro da Silva, Julio Kornetz, Daniel Zamith-Miranda, Alessandro F. Valdez, Joshua D. Nosanchuk, Eduardo Gonçalves Paterson Fox, Leonardo Nimrichter
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
The urgency surrounding Candida auris as a public health threat is highlighted by both the Center for Disease Control (CDC) and World Health Organization (WHO) that categorized this species as a priority fungal pathogen. Given the current limitations
Externí odkaz:
https://doaj.org/article/de45cd0678af4ece8213bd76bd7937ee
Autor:
Elisa Gonçalves Medeiros, Michele Ramos Valente, Leandro Honorato, Marina da Silva Ferreira, Susana Ruiz Mendoza, Diego de Souza Gonçalves, Lucas Martins Alcântara, Kamilla Xavier Gomes, Marcia Ribeiro Pinto, Ernesto S. Nakayasu, Geremy Clair, Isadora Filipaki Munhoz da Rocha, Flavia C. G. dos Reis, Marcio L. Rodrigues, Lysangela R. Alves, Leonardo Nimrichter, Arturo Casadevall, Allan Jefferson Guimarães
Publikováno v:
mSystems, Vol 9, Iss 6 (2024)
ABSTRACT We conducted a comprehensive comparative analysis of extracellular vesicles (EVs) from two Acanthamoeba castellanii strains, Neff (environmental) and T4 (clinical). Morphological analysis via transmission electron microscopy revealed slightl
Externí odkaz:
https://doaj.org/article/6d88a4b62eab476089b31eb9bf95d733
Autor:
Isabella Dib Ferreira Gremião, Gabriela Reis Pereira-Oliveira, Sandro Antonio Pereira, Maria Lopes Corrêa, Luana Pereira Borba-Santos, Alessandra Lifsitch Viçosa, Ashna Garg, Krupanandan Haranahalli, Deveney Dasilva, Nivea Pereira de Sa, Gabriel S. Matos, Vanessa Silva, Cristina Lazzarini, Caroline Mota Fernandes, Kildare Miranda, Jhon Jhamilton Artunduaga Bonilla, Anna Letícia Nunes, Leonardo Nimrichter, Iwao Ojima, John Mallamo, John B. McCarthy, Maurizio Del Poeta
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT Acylhydrazone (AH) derivatives represent a novel category of anti-fungal medications that exhibit potent activity against Sporothrix sp., both in vitro and in a murine model of sporotrichosis. In this study, we demonstrated the anti-fungal e
Externí odkaz:
https://doaj.org/article/9a2aba0c9d7847cbb62ff4a8532b18f8
Autor:
Juliana Rizzo, Adèle Trottier, Frédérique Moyrand, Jean-Yves Coppée, Corinne Maufrais, Ana Claudia G. Zimbres, Thi Tuong Vi Dang, Alexandre Alanio, Marie Desnos-Ollivier, Isabelle Mouyna, Gérard Péhau-Arnaude, Pierre-Henri Commere, Sophie Novault, Iuliana V. Ene, Leonardo Nimrichter, Marcio L. Rodrigues, Guilhem Janbon
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resist
Externí odkaz:
https://doaj.org/article/1274a0989de04827bef057b1db4905e4
Autor:
Alessandro F. Valdez, Daniel Zamith Miranda, Allan Jefferson Guimarães, Leonardo Nimrichter, Joshua D. Nosanchuk
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 1900-1919 (2022)
Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus Histoplasma capsulatum. Although healthy individuals can develop histoplasmosis, the disease is particularly life-threatening in immunocompromised patients, with a wide ran
Externí odkaz:
https://doaj.org/article/dd552c3326c44fb98e27144d0f766e93
Autor:
Alessandro F. Valdez, Taiane Nascimento de Souza, Jhon Jhamilton Artunduaga Bonilla, Daniel Zamith-Miranda, Alicia Corbellini Piffer, Glauber R. S. Araujo, Allan J. Guimarães, Susana Frases, Alana Kelyene Pereira, Taicia Pacheco Fill, Igor L. Estevao, Angel Torres, Igor C. Almeida, Joshua D. Nosanchuk, Leonardo Nimrichter
Publikováno v:
Journal of Fungi, Vol 9, Iss 11, p 1052 (2023)
Histoplasma capsulatum is the causative agent of histoplasmosis. Treating this fungal infection conventionally has significant limitations, prompting the search for alternative therapies. In this context, fungal extracellular vesicles (EVs) hold rele
Externí odkaz:
https://doaj.org/article/045f6559ac2f452fac67bbf4f87115c3
Autor:
Israel Diniz-Lima, Pablo Rodrigo da Rosa, Elias Barbosa da Silva-Junior, Joyce Cristina Guimarães-de-Oliveira, Elisangela Oliveira de Freitas, Danielle de Oliveira Nascimento, Alexandre Morrot, Leonardo Nimrichter, Jose Osvaldo Previato, Lucia Mendonça-Previato, Leonardo Freire-de-Lima, Debora Decote-Ricardo, Celio Geraldo Freire-de-Lima
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Cryptococcosis is an opportunistic disease caused by the fungus Cryptococcus neoformans and Cryptococcus gattii. It starts as a pulmonary infection that can spread to other organs, such as the brain, leading to the most serious occurrence of
Externí odkaz:
https://doaj.org/article/04abe7e76106492ca660dae9f8631235
Autor:
Caroline Mota Fernandes, Tyler G. Normile, Joao Henrique Tadini Marilhano Fabri, Veronica Soares Brauer, Glauber R. de S. Araújo, Susana Frases, Leonardo Nimrichter, Iran Malavazi, Maurizio Del Poeta
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Aspergillus fumigatus causes invasive aspergillosis (IA) in immunocompromised patients, resulting in high mortality rates. Currently, no vaccine formulations to promote immune protection in at-risk individuals have been developed. In this wo
Externí odkaz:
https://doaj.org/article/64fcee8035134ad1a05e76da7106cd8f