Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis

Autor: Luca Muzio, Riccardo Sirtori, Davide Gornati, Simona Eleuteri, Andrea Fossaghi, Diego Brancaccio, Leonardo Manzoni, Linda Ottoboni, Luca De Feo, Angelo Quattrini, Eloise Mastrangelo, Luca Sorrentino, Emanuele Scalone, Giancarlo Comi, Luciana Marinelli, Nilo Riva, Mario Milani, Pierfausto Seneci, Gianvito Martino

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

ALS is a neurodegenerative disease characterized by loss of motor neurons. Here, the authors showed that reduced levels of the VSP35 subunit in the retromer complex is a conserved ALS feature and identified a new lead compound increasing retromer sta

Externí odkaz: https://doaj.org/article/2a79c2c4685b4d2598d773092d995d7b

Integrin-Targeted Peptide- and Peptidomimetic-Drug Conjugates for the Treatment of Tumors

Autor: Daniela Arosio, Paola Perego, Cristina Corno, Leonardo Manzoni

Publikováno v: Recent patents on anti-cancer drug discovery
(2017): 148–168. doi:10.2174/1574892812666170203151930
info:cnr-pdr/source/autori:Arosio, Daniela; Manzoni, Leonardo; Corno, Cristina; Perego, Paola/titolo:Integrin-targeted peptide-and peptidomimetic-drug conjugates for the treatment of tumors./doi:10.2174%2F1574892812666170203151930/rivista:Recent patents on anti-cancer drug discovery (Print)/anno:2017/pagina_da:148/pagina_a:168/intervallo_pagine:148–168/volume

Background: Integrins are heterodimeric cell surface receptors that mediate cell-cell and cellextracellular matrix adhesion. These molecules play a role in processes such as cell growth and proliferation, differentiation, migration, cell trafficking,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90b794250b07e620c88c80c0036dd34
https://doi.org/10.2174/1574892812666170203151930

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors

Autor: Luciana Marinelli, Preet Lal, Emiliano Biasini, Chiara Zucal, Alessandro Provenzani, Vito Giuseppe D'Agostino, Pierfausto Seneci, Vanessa Baj, Natthakan Thongon, Saioa R. Elezgarai, Danilo Di Maio, Linda Cerofolini, Claudio Luchinat, Leonardo Manzoni, Ettore Novellino, Marta Brambilla, Marco Fragai, Marco Miceli, Isabelle Bonomo

Publikováno v: Journal of medicinal chemistry 61 (2018): 1483–1498. doi:10.1021/acs.jmedchem.7b01176
info:cnr-pdr/source/autori:Manzoni L.; Zucal C.; Maio D.D.; D'Agostino V.G.; Thongon N.; Bonomo I.; Lal P.; Miceli M.; Baj V.; Brambilla M.; Cerofolini L.; Elezgarai S.; Biasini E.; Luchinat C.; Novellino E.; Fragai M.; Marinelli L.; Provenzani A.; Seneci P./titolo:Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors/doi:10.1021%2Facs.jmedchem.7b01176/rivista:Journal of medicinal chemistry/anno:2018/pagina_da:1483/pagina_a:1498/intervallo_pagine:1483–1498/volume:61

The human antigen R (HuR) is an RNA-binding protein known to modulate the expression of target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress responses and is a valuable drug target. We previously found that dihydrotansh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909b50e95821430ff362c6edb7f96dee
https://pubmed.ncbi.nlm.nih.gov/29313684

Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ6 Integrin by Biochemical and Molecular Docking Studies

Autor: Daniela Arosio, Umberto Piarulli, Laura Belvisi, Simone Zanella, Luca Pignataro, Cesare Gennari, Leonardo Manzoni, Francesca Bonato, Monica Civera

Publikováno v: Cancers, Vol 9, Iss 10, p 128 (2017)
Cancers (Basel) 9 (2017). doi:10.3390/cancers9100128
info:cnr-pdr/source/autori:Civera, Monica; Arosio, Daniela; Bonato, Francesca; Manzoni, Leonardo; Pignataro, Luca; Zanella, Simone; Gennari, Cesare; Piarulli, Umberto; Belvisi, Laura/titolo:Investigating the Interaction of Cyclic RGD Peptidomimetics with alphaVbeta6 Integrin by Biochemical and Molecular Docking Studies./doi:10.3390%2Fcancers9100128/rivista:Cancers (Basel)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:9
Cancers
Cancers; Volume 9; Issue 10; Pages: 128

The interaction of a small library of cyclic RGD (Arg-Gly-Asp) peptidomimetics with alphaVbeta6 integrin has been investigated by means of competitive solid phase binding assays to the isolated receptor and docking calculations in the crystal structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f278903b927291754abc365522a72bf8
https://www.mdpi.com/2072-6694/9/10/128

Regulation of HuR structure and function by dihydrotanshinone-I

Autor: Ranjan Preet, Luciana Marinelli, Pierfausto Seneci, Emiliano Biasini, Linda Cerofolini, Ettore Novellino, Vito Giuseppe D'Agostino, Dan A. Dixon, Vikalp Vishwakarma, Isabelle Bonomo, Carmelo Fuccio, Max S. Fairlamb, Sha Neisha Williams, Marco Fragai, Preet Lal, Saioa R. Elezgarai, Rachel Munk, Alessandro Provenzani, Kotb Abdelmohsen, Chiara Zucal, Myriam Gorospe, Erik Dassi, Danilo Di Maio, Claudio Luchinat, Elin Lehrmann, Stefano Giuntini, Leonardo Manzoni, Alessandro Quattrone

Publikováno v: Nucleic Acids Research
Nucleic acids research 45 (2017): 9514–9527. doi:10.1093/nar/gkx623
info:cnr-pdr/source/autori:Lal, Preet; Cerofolini, Linda; D'Agostino, Vito Giuseppe; Zucal, Chiara; Fuccio, Carmelo; Bonomo, Isabelle; Dassi, Erik; Giuntini, Stefano; Di Maio, Danilo; Vishwakarma, Vikalp; Preet, Ranjan; Williams, Sha Neisha; Fairlamb, Max S.; Munk, Rachel; Lehrmann, Elin; Abdelmohsen, Kotb; Elezgarai, Saioa R.; Luchinat, Claudio; Novellino, Ettore; Quattrone, Alessandro; Biasini, Emiliano; Manzoni, Leonardo; Gorospe, Myriam; Dixon, Dan A.; Seneci, Pierfausto; Marinelli, Luciana; Fragai, Marco; Provenzani, Alessandro/titolo:Regulation of HuR structure and function by dihydrotanshinone-I/doi:10.1093%2Fnar%2Fgkx623/rivista:Nucleic acids research/anno:2017/pagina_da:9514/pagina_a:9527/intervallo_pagine:9514–9527/volume:45

The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post-transcriptionally regulates the fate of target RNAs. The natural product dihydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0536c8768e996bb44932195f81ad5642
http://hdl.handle.net/11588/700351