Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Leonardo Lonati"'
Autor:
Greta Pessino, Leonardo Lonati, Claudia Scotti, Silvia Calandra, Ornella Cazzalini, Ombretta Iaria, Andrea Previtali, Giorgio Baiocco, Paola Perucca, Anna Tricarico, Martina Vetro, Lucia Anna Stivala, Carlo Ganini, Marta Cancelliere, Massimo Zucchetti, Isabella Guardamagna, Maristella Maggi
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35789- (2024)
Asparagine and glutamine depletion operated by the drug Asparaginase (ASNase) has revolutionized therapy in pediatric patients affected by Acute Lymphoblastic Leukemia (ALL), bringing remissions to a remarkable 90 % of cases. However, the knowledge o
Externí odkaz:
https://doaj.org/article/8328c688f1b84c4c9e71693bf28ebd4c
Autor:
Patrizia Morciano, Valentina Dini, Francesco Berardinelli, Giorgio Baiocco, Valeria Conte, Ion Udroiu, Federica Barbato, Jessica Marinaccio, Pasqualino Anello, Antonio Antoccia, Maria Antonella Tabocchini, Anna Selva, Stefania Canella, Anna Bianchi, Isabella Guardamagna, Leonardo Lonati, Emanuele Scifoni, Matthias Laubenstein, Marco Balata, Francesco Ferella, Daniela Grifoni, Angelo Galante, Mauro Maccarrone, Valentina Tirelli, Felicia Grasso, Massimo Sanchez, Antonella Sgura
Publikováno v:
Frontiers in Physics, Vol 11 (2023)
One of the most intriguing and still pending questions in radiobiology is to understand whether and how natural environmental background radiation has shaped Life over millions of years of evolution on Earth. Deep Underground Laboratories (DULs) repr
Externí odkaz:
https://doaj.org/article/d00972e172f14195970227bf0a30fed0
Autor:
Isabella Guardamagna, Ombretta Iaria, Leonardo Lonati, Alice Mentana, Andrea Previtali, Virginia Uggè, Giovanni Battista Ivaldi, Marco Liotta, Paola Tabarelli de Fatis, Claudia Scotti, Greta Pessino, Maristella Maggi, Giorgio Baiocco
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2983 (2023)
Colorectal cancer (CRC) is the most prominent form of colon cancer for both incidence (38.7 per 100,000 people) and mortality (13.9 per 100,000 people). CRC’s poor response to standard therapies is linked to its high heterogeneity and complex genet
Externí odkaz:
https://doaj.org/article/cc3ebc4a33d84630ac145ab06cea134e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Cell cycle progression can be studied with computational models that allow to describe and predict its perturbation by agents as ionizing radiation or drugs. Such models can then be integrated in tools for pre-clinical/clinical use, e.g. to
Externí odkaz:
https://doaj.org/article/2b097abc6ab845088c36d0c7ec402527
Autor:
Isabella Guardamagna, Leonardo Lonati, Monica Savio, Lucia A. Stivala, Andrea Ottolenghi, Giorgio Baiocco
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Colorectal cancer is among the three top cancer types for incidence and the second in terms of mortality, usually managed with surgery, chemotherapy and radiotherapy. In particular, radiotherapeutic concepts are crucial for the management of advanced
Externí odkaz:
https://doaj.org/article/afe25c0906f9455c8bb6b503c252f0a5
Autor:
Giuseppina Borsci, Sofia Barbieri, Isabella Guardamagna, Leonardo Lonati, Andrea Ottolenghi, Giovanni Battista Ivaldi, Marco Liotta, Paola Tabarelli de Fatis, Giorgio Baiocco, Monica Savio
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In vitro co-culture models between tumor cells and peripheral blood mononuclear cells (PBMCs) allow studying the interplay between these cell populations, potentially gaining insight into the in vivo response of the immune system to the presence of t
Externí odkaz:
https://doaj.org/article/aaf81347079c4241986f5a3ae2ecccca
Autor:
Maristella Maggi, Greta Pessino, Isabella Guardamagna, Leonardo Lonati, Cristina Pulimeno, Claudia Scotti
Publikováno v:
Cancers, Vol 13, Iss 22, p 5637 (2021)
E. coli L-asparaginase is an amidohydrolase (EC 3.5.1.1) which has been successfully used for the treatment of Acute Lymphoblastic Leukemia for over 50 years. Despite its efficacy, its side effects, and especially its intrinsic immunogenicity, hamper
Externí odkaz:
https://doaj.org/article/0aec481af2694847a11eac4671973910
Autor:
Alice Mentana, Virgilio Quaresima, Pavel Kundrát, Isabella Guardamagna, Leonardo Lonati, Ombretta Iaria, Luca Di Fino, Giulia Romoli, Giorgia Santi Amantini, Livio Narici, Giorgio Baiocco
We present new developments for an ab-initio model of the neutron relative biological effectiveness (RBE) in inducing specific classes of DNA damage. RBE is evaluated as a function of the incident neutron energy and of the depth inside a human-sized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::594e3c4379e47083982bdeaef8113cd1
https://doi.org/10.21203/rs.3.rs-2713455/v1
https://doi.org/10.21203/rs.3.rs-2713455/v1
Autor:
Alice Mentana, Yordenca Lamartinière, Thierry Orsière, Véronique Malard, Mickaël Payet, Danielle Slomberg, Isabella Guardamagna, Leonardo Lonati, Cristian Grisolia, Awadhesh Jha, Laurence Lebaron-Jacobs, Jerome Rose, Andrea Ottolenghi, Giorgio Baiocco
Publikováno v:
Radiation Research
Radiation Research, 2023, 199, pp.25-38. ⟨10.1667/RADE-22-00043.1⟩
Radiation Research, 2023, 199, pp.25-38. ⟨10.1667/RADE-22-00043.1⟩
International audience; Biological effects of radioactive particles can be experimentally investigated in vitro as a function of particle concentration, specific activity and exposure time. However, a careful dosimetric analysis is needed to elucidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054537967016219a46d3d8b07b15ad36
https://hal.science/hal-03880858/file/Mentana_2023.pdf
https://hal.science/hal-03880858/file/Mentana_2023.pdf
Autor:
Isabella Guardamagna, Cristina Pulimeno, Greta Pessino, Maristella Maggi, Leonardo Lonati, Claudia Scotti
Publikováno v:
Cancers, Vol 13, Iss 5637, p 5637 (2021)
Cancers
Volume 13
Issue 22
Cancers
Volume 13
Issue 22
Simple Summary The therapy of Acute Lymphoblastic Leukemia (ALL) is based on Escherichia coli (E. coli) L-asparaginase, which is a very effective drug in most cases. However, its side effects sometimes prevent its usage or impose its interruption. Th