Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Leonardo Lisbôa da Motta"'
Autor:
Gabriel S Macedo, Leonardo Lisbôa da Motta, Juliana Giacomazzi, Cristina B O Netto, Vanusa Manfredini, Camila S Vanzin, Carmen Regla Vargas, Pierre Hainaut, Fábio Klamt, Patricia Ashton-Prolla
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47010 (2012)
Germline mutations in TP53 are the underlying defect of Li-Fraumeni Syndrome (LFS) and Li-Fraumeni-like (LFL) Syndrome, autosomal dominant disorders characterized by predisposition to multiple early onset cancers. In Brazil, a variant form of LFS/LFL
Externí odkaz:
https://doaj.org/article/2bd510bbc68a40c0a63d3e448cb1aeba
Autor:
Fernanda Martins Lopes, Leonardo Lisbôa da Motta, Fábio Klamt, Richard B. Parsons, Ivi Juliana Bristot
Publikováno v:
NeuroMolecular Medicine. 19:241-255
Parkinson's disease (PD) is the second most common neurodegenerative disorder and has both unknown etiology and non-curative therapeutic options. Patients begin to present the classic motor symptoms of PD-tremor at rest, bradykinesia and rigidity-onc
Autor:
Fábio Klamt, Leonardo Lisbôa da Motta, Melissa Medeiros Markoski, Maximiliano I. Schaun, Rayane Teixeira, Maria Claudia Irigoyen, Juliane da Silva Rossato, Alexandre Machado Lehnen
Publikováno v:
International Journal of Sport Nutrition and Exercise Metabolism. 27:197-203
In acute myocardial infarction (AMI), reactive oxygen species may cause irreversible damage to the heart tissue. Physical training is capable of enhancing antioxidant capacity, acting as a cardioprotective factor. We assessed the preventive effects o
Autor:
Leonardo Lisbôa da Motta, Fábio Klamt, Carolina Guerini de Souza, Ricardo S. Bruch, Diogo O. Souza, Adriano Martimbianco de Assis, Anderson Rech
Publikováno v:
Food & Function. 7:2060-2065
Diabetes is one of the most prevalent chronic non-communicable diseases and is characterized by hyperglycemia and increased oxidative stress. These two alterations are also responsible for the main diabetic complications: cardiovascular disease, reti
Autor:
Bianca Wollenhaupt de Aguiar, Leonardo Lisbôa da Motta, Liana Marengo de Medeiros, Richard B. Parsons, Alcir Luiz Dafre, Daiani Machado de Vargas, Fábio Klamt, Valder N. Freire, Mauro A. A. Castro, Luiz Felipe de Souza, Geancarlo Zanatta, Fernanda Martins Lopes, Patrícia Schonhofen, Marco Antônio De Bastiani, Giovana Ferreira Londero, Bianca Pfaffenseller
Publikováno v:
Lopes, F, da Motta, L L, de Bastiani, M A, Pfaffenseller, B, Aguiar, B W, de Souza, L F, Zanatta, G, Vargas, D M, Schönhofen, P, Londero, G F, de Medeiros, L M, Freire, V N, Dafre, A L, Castro, M A A, Parsons, R & Klamt, F 2017, ' RA Differentiation Enhances Dopaminergic Features, Changes Redox Parameters, and Increases Dopamine Transporter Dependency in 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells ', NEUROTOXICITY RESEARCH, vol. 31, no. 4, pp. 545-559 . https://doi.org/10.1007/s12640-016-9699-0
Research on Parkinson’s disease (PD) and drug development is hampered by the lack of suitable human in vitro models that simply and accurately recreate the disease conditions. To counteract this, many attempts to differentiate cell lines, such as t
Autor:
Candelaria Bracalente, Leonardo Lisbôa da Motta, Carolina Beatriz Müller, Irene L. Ibañez, Fábio Klamt, Cintia Notcovich, Noelia Salguero, Hebe Durán
Publikováno v:
Oncotarget
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Advanced melanoma is the most aggressive form of skin cancer. It is highlymetastatic and dysfunctional in melanogenesis; two processes that are induced byH2O2. This work presents a melanoma cell model with low levels of H2O2 inducedby catalase overex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bccc563fa8fe126360691a5cf0cacbb
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=9220&path[]=28338
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=9220&path[]=28338
Autor:
Benicio N. Frey, Carlos Eduardo Schnorr, José Cláudio Fonseca Moreira, André Simões-Pires, Leonardo Lisbôa da Motta, Guilherme Antônio Behr
Publikováno v:
Cell Biology and Toxicology. 28:317-330
Previous studies have linked oxidative stress with aging and aging-related processes, including menopause. Abnormalities in the redox state similar to those observed in menopausal women can be modeled experimentally with rat ovariectomy. The aim of t
Autor:
Fábio Klamt, Marco Antônio De Bastiani, Fernanda Martins Lopes, Leonardo Lisbôa da Motta, Mauro A. A. Castro, Valeska Aguiar de Oliveira, Carolina Beatriz Müller, Bernardo Papini Gabiatti, Fernanda Stapenhorst França
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37(8)
Lung cancer is the most lethal cancer-related disease worldwide. Since survival rates remain poor, there is an urgent need for more effective therapies that could increase the overall survival of lung cancer patients. Lung tumors exhibit increased le
Autor:
Flávio Kapczinski, Gabriela D. Colpo, Ricardo Silva, Karen Jansen, Leonardo Lisbôa da Motta, Pedro Vieira da Silva Magalhães, Ricardo Tavares Pinheiro, Fábio Klamt
Publikováno v:
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Systemic toxicity is a relevant dimension of pathophysiology in bipolar disorder, and oxidative damage isone potential link between central and peripheral pathology. Although there is mounting evidence thatchronic bipolar disorder is associated with
PO-276 Histone acetylation readers BET in hypoxia adaptation in triple negative breast cancer (TNBC)
Autor:
Alan McIntyre, Dilair Baban, M A De Bastiani, I. Ledaki, D. Heery, K. Stefan, Leonardo Lisbôa da Motta, Shozeb Haider, Fábio Klamt, A L Harris
Publikováno v:
ESMO Open. 3:A335
Introduction Hypoxia (low oxygen) is associated with worst prognosis and therapy resistance in most solid tumours. Hypoxia occurs in ~50% of breast cancer, most frequently in triple negative breast cancer (TNBC), the most aggressive subtype. Hypoxia