3D and 4D bioprinted human model patenting and the future of drug development

Autor: Luiza Amara Maciel Braga, Fabio Batista Mota, Bernardo Pereira Cabral, Leonardo L. Rocha

Publikováno v: Nature biotechnology. 38(6)

Bioprinted 3D and 4D tissues and organs are expected to revolutionize the biomedical field, eliminating the need for laboratory animals, but little is known about the future impacts of these technologies on drug development.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ffb88db0940a73d5cfc17938d4dfda
https://pubmed.ncbi.nlm.nih.gov/32518405

Transcriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes

Autor: Regina Coeli dos Santos Goldenberg, Sanda Iacobas, Herbert B. Tanowitz, Fnu Nagajyothi, Fabio S. A. Fortes, Leonardo L. Rocha, Dumitru A. Iacobas, Antonio Carlos Carvalho, David C. Spray, Leandro Vairo

Publikováno v: Microbes and Infection. 11:1140-1149

Trypanosoma cruzi infection is a major cause of cardiomyopathy. Previous gene profiling studies of infected mouse hearts have revealed prominent changes in gene expression within many functional pathways. This variety of transcriptomic changes in inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ae9a9a569b4260a1a09c1766157e81
https://doi.org/10.1016/j.micinf.2009.08.009

Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy

Autor: Ricardo Ribeiro dos Santos, Silvia Regina Rogatto, Regina Coeli dos Santos Goldenberg, Sanda Iacobas, Herbert B. Tanowitz, Juliana Fraga Vasconcelos, David C. Spray, Milena Botelho Pereira Soares, Ricardo Lima, Dumitru A. Iacobas, Leonardo L. Rocha, Antonio Carlos Carvalho

Publikováno v: The Journal of infectious diseases. 202(3)

Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1291ddb31862ae5eceefc4484524a0
https://pubmed.ncbi.nlm.nih.gov/20565256

Semantic Academic Profiler (SAP): a framework for researcher assessment based on semantic topic modeling.

Autor: Viegas F; Department of Computer Science, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais Brazil., Pereira A; Department of Computer Science, Federal University of São João Del Rey, São João Del Rey, Minas Gerais Brazil., Cecílio P; Department of Computer Science, Federal University of São João Del Rey, São João Del Rey, Minas Gerais Brazil., Tuler E; Department of Computer Science, Federal University of São João Del Rey, São João Del Rey, Minas Gerais Brazil., Meira W Jr; Department of Computer Science, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais Brazil., Gonçalves M; Department of Computer Science, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais Brazil., Rocha L; Department of Computer Science, Federal University of São João Del Rey, São João Del Rey, Minas Gerais Brazil.

Publikováno v: Scientometrics [Scientometrics] 2022; Vol. 127 (8), pp. 5005-5026. Date of Electronic Publication: 2022 Jul 11.

3D and 4D bioprinted human model patenting and the future of drug development.

Autor: Mota F; Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. fabio.mota@fiocruz.br., Braga L; Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Rocha L; Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Cabral B; Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2020 Jun; Vol. 38 (6), pp. 689-694.