Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Leonardo J. Leon"'
Autor:
Wenjing Liang, Shakti Sagar, Rishith Ravindran, Rita H. Najor, Justin M. Quiles, Liguo Chi, Rachel Y. Diao, Benjamin P. Woodall, Leonardo J. Leon, Erika Zumaya, Jason Duran, David M. Cauvi, Antonio De Maio, Eric D. Adler, Åsa B. Gustafsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mitochondrial quality control is critical for cardiac homeostasis as these organelles are responsible for generating most of the energy needed to sustain contraction. Dysfunctional mitochondria are normally degraded via intracellular degrada
Externí odkaz:
https://doaj.org/article/02588d67bd4f4beeb14563fa5e5e84d7
Autor:
Babette C. Hammerling, Rita H. Najor, Melissa Q. Cortez, Sarah E. Shires, Leonardo J. Leon, Eileen R. Gonzalez, Daniela Boassa, Sébastien Phan, Andrea Thor, Rebecca E. Jimenez, Hong Li, Richard N. Kitsis, Gerald W. Dorn II, Junichi Sadoshima, Mark H. Ellisman, Åsa B. Gustafsson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Damaged mitochondria are normally cleared through canonical and alternative autophagy pathways. Here, the authors report that mitochondria can be cleared through an autophagy-independent endosomal-lysosomal pathway that depends on Parkin-dependent se
Externí odkaz:
https://doaj.org/article/b90a7538f1694e4281da0c789cbd7c2c
Autor:
Leonardo J. Leon, Amabel M. Orogo, Åsa B. Gustafsson, Alexandra G. Moyzis, Navraj S. Lally, Rita H. Najor, Wenjing Liang
Publikováno v:
J Mol Cell Cardiol
Myeloid cell leukemia-1 (Mcl-1) is a structurally and functionally unique anti-apoptotic Bcl-2 protein. While elevated levels of Mcl-1 contribute to tumor cell survival and drug resistance, loss of Mcl-1 in cardiac myocytes leads to rapid mitochondri
Autor:
Ouyang Kunfu, Anh T. Nguyen, Wei Feng, Siting Zhu, Liguo Chi, Leonardo J Leon, Sylvia M. Evans, Simone Spinozzi, Frédéric M. Vaz, Yi Zhou, Åsa B. Gustafsson, Mason Zhu, Ying Shen, Changming Tan, Yusu Gu, Zee Chen, Xi Fang, Xiaohong Wang
Publikováno v:
Circulation. Heart failure, 708-721. Lippincott Williams and Wilkins
STARTPAGE=708;ENDPAGE=721;ISSN=1941-3289;TITLE=Circulation. Heart failure
Circ Heart Fail
STARTPAGE=708;ENDPAGE=721;ISSN=1941-3289;TITLE=Circulation. Heart failure
Circ Heart Fail
Background: Cardiomyopathy is a major clinical feature in Barth syndrome (BTHS), an X-linked mitochondrial lipid disorder caused by mutations in Tafazzin ( TAZ ), encoding a mitochondrial acyltransferase required for cardiolipin remodeling. Despite r
Autor:
Mark A Lampert, Rita H. Najor, Adam Mark, Åsa B. Gustafsson, Sarah E. Shires, Leonardo J. Leon, Justin M. Quiles, Melissa Q. Cortez
Publikováno v:
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Parkin is an E3 ubiquitin ligase well-known for facilitating clearance of damaged mitochondria by ubiquitinating proteins on the outer mitochondrial membrane. However, knowledge of Parkin’s functions beyond mitophagy is still limited. Here, we demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d78528eb4fc4226a7c8014d0fd9d84
https://escholarship.org/uc/item/4j968324
https://escholarship.org/uc/item/4j968324
Autor:
Daniela Boassa, Babette C. Hammerling, Richard N. Kitsis, Sebastien Phan, Hong Li, Rebecca E. Jimenez, Åsa B. Gustafsson, Sarah E. Shires, Mark H. Ellisman, Melissa Q. Cortez, Gerald W. Dorn, Eileen R. Gonzalez, Junichi Sadoshima, Andrea Thor, Rita H. Najor, Leonardo J. Leon
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is autophagy, where damaged organelles are marked for disposal via ubiquitylation by Parkin. He
Publikováno v:
Circulation Research. 125
Myeloid Cell Leukemia-1 (MCL-1) is an anti-apoptotic BCL-2 protein upregulated in various types of cancer. It is also highly expressed in the myocardium. We previously found that MCL-1 plays a key role in maintaining mitochondrial homeostasis and myo
Abstract 166: MCL-1 Facilitates the Removal of Damaged Mitochondria via the Mitophagy Receptor BNIP3
Publikováno v:
Circulation Research. 125
Myeloid Cell Leukemia-1 (MCL-1) is an anti-apoptotic BCL-2 family protein that is necessary to maintain cardiac homeostasis in the adult heart. MCL-1 localizes to two distinct mitochondrial locations in myocytes, both on the outer mitochondrial membr
Publikováno v:
Circulation Research. 125
Parkin facilitates mitophagy by ubiquitinating depolarized mitochondria to label them for degradation. We have previously shown that Parkin is important for adaptation to myocardial infarction (MI) and that loss of Parkin leads to accumulation of dys
Publikováno v:
Circulation Research. 125
The anti-apoptotic BCL-2 family member, Myeloid Cell Leukemia-1 (MCl-1), is highly expressed in myocardium and plays a critical role in maintaining mitochondrial homeostasis. We have previously found that cardiomyocyte-specific MCL-1 knockout mice de