Whole blood transfusion improves vascular integrity and increases survival in artemether-treated experimental cerebral malaria

Autor: Saba Gul, Flavia L. Ribeiro-Gomes, Aline S. Moreira, Guilherme S. Sanches, Fabiana G. Conceição, Cláudio Tadeu Daniel-Ribeiro, Hans C. Ackerman, Leonardo J. M. Carvalho

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Pathological features observed in both human and experimental cerebral malaria (ECM) are endothelial dysfunction and changes in blood components. Blood transfusion has been routinely used in patients with severe malarial anemia and can also

Externí odkaz: https://doaj.org/article/b8ef0055519d46e8a9563dd4cc95860d

Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds

Autor: Kamilla Rodrigues Rogerio, Leonardo J M Carvalho, Luiza Helena Pinto Domingues, Bruno Junior Neves, José Teófilo Moreira Filho, Rosane Nora Castro, Cesare Bianco Júnior, Claudio Tadeu Daniel-Ribeiro, Carolina Horta Andrade, Cedric Stephan Graebin

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 113, Iss 8 (2018)

BACKGROUND Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs. Thus, the search fo

Externí odkaz: https://doaj.org/article/5f961a9c94384129912dea3adadd8440

Activities of artesunate-based combinations and tafenoquine against Babesia bovis in vitro and Babesia microti in vivo

Autor: Arifin Budiman Nugraha, Naoaki Yokoyama, Thillaiampalam Sivakumar, Bunduurem Tuvshintulga, Leonardo J M Carvalho

Publikováno v: Parasites & Vectors, Vol 13, Iss 1, Pp 1-9 (2020)
Parasites & Vectors

Background Babesiosis represents a veterinary and medical threat, with a need for novel drugs. Artemisinin-based combination therapies (ACT) have been successfully implemented for malaria, a human disease caused by related parasites, Plasmodium spp.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e25bc6bee79e15a26e24a0498a9fba
http://link.springer.com/article/10.1186/s13071-020-04235-7

Perillyl alcohol reduces parasite sequestration and cerebrovascular dysfunction during experimental cerebral malaria

Autor: Daniella S. Battagello, Alejandro M. Katzin, Jackson C. Bittencourt, Luana dos Santos Ortolan, Adriana A Marin, Thatyane de Castro Quirino, Sabrina Epiphanio, Leonardo J M Carvalho, Rodrigo A.C. Sussmann, Oscar Murillo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Antimicrob Agents Chemother

Cerebral malaria (CM) is a severe immune vasculopathy which presents a high mortality rate (15 to 20%), despite the availability of artemisinin-based therapy. More effective immunomodulatory and/or antiparasitic therapies are urgently needed. Experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a3bab798bf9b58af30e917c095cc89

Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria.

Autor: Peng Kai Ong, Benoît Melchior, Yuri C Martins, Anthony Hofer, Pamela Orjuela-Sánchez, Pedro Cabrales, Graziela M Zanini, John A Frangos, Leonardo J M Carvalho

Publikováno v: PLoS Pathogens, Vol 9, Iss 6, p e1003444 (2013)

Cerebrovascular dysfunction plays a key role in the pathogenesis of cerebral malaria. In experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA, cerebrovascular dysfunction characterized by vascular constriction, occlusion and damage

Externí odkaz: https://doaj.org/article/bc225a2350894492805c291cd8e6e88d