Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Leonardo Guasti"'
Autor:
Gerard Ruiz-Babot, Ariane Eceiza, Fernando Abollo-Jiménez, Maria Malyukov, Diana L. Carlone, Kleiton Borges, Alexandra Rodrigues Da Costa, Shamma Qarin, Takuya Matsumoto, Ryuji Morizane, William C. Skarnes, Barbara Ludwig, Paul J. Chapple, Leonardo Guasti, Helen L. Storr, Stefan R. Bornstein, David T. Breault
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 11, Pp 100627- (2023)
Summary: Adrenal insufficiency is a life-threatening condition resulting from the inability to produce adrenal hormones in a dose- and time-dependent manner. Establishing a cell-based therapy would provide a physiologically responsive approach for th
Externí odkaz:
https://doaj.org/article/6ac601e73ba74f568125dbf81561e3a8
Autor:
Jayna N. Mistry, Sanna Silvennoinen, Farasat Zaman, Lars Sävendahl, Katia Mariniello, Charlotte Hall, Sasha R. Howard, Leo Dunkel, Ulla Sankilampi, Leonardo Guasti
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundFibroblast growth factor 21 (FGF21) is an essential metabolic regulator that adapts to changes in nutritional status. Severe childhood undernutrition induces elevated FGF21 levels, contributing to growth hormone (GH) resistance and subseque
Externí odkaz:
https://doaj.org/article/8fb2106743fc4273b62822f4b5654237
Autor:
Leonardo Guasti, Luisella Cianferotti, Barbara Pampaloni, Francesco Tonelli, Francesco Martelli, Teresa Iantomasi, Maria Luisa Brandi
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionBoth osteoporosis and periodontitis are pathologies characterized by an imbalance in the bone tissue. Vitamin C is an important factor involved in maintaining the health of the periodontium; its deficiency causes characteristic lesions to
Externí odkaz:
https://doaj.org/article/fea569148cf24bf4b4143dc3f77054df
Autor:
Tansit Saengkaew, Gerard Ruiz-Babot, Alessia David, Alessandra Mancini, Katia Mariniello, Claudia P. Cabrera, Michael R. Barnes, Leo Dunkel, Leonardo Guasti, Sasha R. Howard
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Developmental abnormalities of the gonadotropin-releasing hormone (GnRH) neuronal network result in a range of conditions from idiopathic hypogonadotropic hypogonadism to self-limited delayed puberty. We aimed to discover important underlyin
Externí odkaz:
https://doaj.org/article/195e4011c5954a6397296b9e94e96e42
Autor:
Sonia Hasan, Francis Delicata, Leonardo Guasti, Claudia Duranti, Fatemah Mousalem Haidar, Annarosa Arcangeli, Paola Imbrici, Mauro Pessia, Mario Valentino, Maria Cristina D’Adamo
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15334 (2022)
Locus coeruleus (LC) neurons, with their extensive innervations throughout the brain, control a broad range of physiological processes. Several ion channels have been characterized in LC neurons that control intrinsic membrane properties and excitabi
Externí odkaz:
https://doaj.org/article/d9a82f5a759a45f7bb6ee16b3bb42346
Autor:
Katia Mariniello, Gerard Ruiz-Babot, Emily C. McGaugh, James G. Nicholson, Angelica Gualtieri, Carles Gaston-Massuet, Maria Cristina Nostro, Leonardo Guasti
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
The endocrine system coordinates a wide array of body functions mainly through secretion of hormones and their actions on target tissues. Over the last decades, a collective effort between developmental biologists, geneticists, and stem cell biologis
Externí odkaz:
https://doaj.org/article/0a74097deff546c2bfee2b3bc04ac940
Autor:
Gerard Ruiz-Babot, Mariya Balyura, Irene Hadjidemetriou, Sharon J. Ajodha, David R. Taylor, Lea Ghataore, Norman F. Taylor, Undine Schubert, Christian G. Ziegler, Helen L. Storr, Maralyn R. Druce, Evelien F. Gevers, William M. Drake, Umasuthan Srirangalingam, Gerard S. Conway, Peter J. King, Louise A. Metherell, Stefan R. Bornstein, Leonardo Guasti
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1236-1249 (2018)
Summary: Adrenal insufficiency is managed by hormone replacement therapy, which is far from optimal; the ability to generate functional steroidogenic cells would offer a unique opportunity for a curative approach to restoring the complex feedback reg
Externí odkaz:
https://doaj.org/article/b1f4e353e7f448a3a66cb5d9fd291cc4
Autor:
Tatiana V Novoselova, Peter J King, Leonardo Guasti, Louise A Metherell, Adrian J L Clark, Li F Chan
Publikováno v:
Endocrine Connections, Vol 8, Iss 7, Pp R122-R130 (2019)
The melanocortin-2-receptor (MC2R), also known as the ACTH receptor, is a critical component of the hypothalamic–pituitary–adrenal axis. The importance of MC2R in adrenal physiology is exemplified by the condition familial glucocorticoid deficien
Externí odkaz:
https://doaj.org/article/fbbcdc59c9ea49b5af7007e908e78ad9
Autor:
Mariya Balyura, Evgeny Gelfgat, Charlotte Steenblock, Andreas Androutsellis-Theotokis, Gerard Ruiz-Babot, Leonardo Guasti, Martin Werdermann, Barbara Ludwig, Tobias Bornstein, Andrew V Schally, Ana Brennand, Stefan R Bornstein
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194643 (2018)
Encapsulation of primary bovine adrenocortical cells in alginate is an efficacious model of a bioartificial adrenal cortex. Such a bioartificial adrenal cortex can be used for the restoration of lost adrenal function in vivo as well as for in vitro m
Externí odkaz:
https://doaj.org/article/5ed18f85dd7a43b5b64d1b6012bf24ac
Autor:
Letizia Vannucci, Caterina Fossi, Sara Quattrini, Leonardo Guasti, Barbara Pampaloni, Giorgio Gronchi, Francesca Giusti, Cecilia Romagnoli, Luisella Cianferotti, Gemma Marcucci, Maria Luisa Brandi
Publikováno v:
Nutrients, Vol 10, Iss 12, p 1930 (2018)
Calcium is an essential element that plays numerous biological functions in the human body, of which one of the most important is skeleton mineralization. Bone is a mineralized connective tissue in which calcium represents the major component, confer
Externí odkaz:
https://doaj.org/article/7f53f370004f4d728c31d8403bd14810