Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus pyogenes

Autor: Usman Nakakana, Alimamy Serry-Bangura, Bassey Effiom Edem, Pietro Tessitore, Leonardo Di Cesare, Danilo Gomes Moriel, Audino Podda, Iris Sarah De Ryck, Ashwani Kumar Arora

Publikováno v: Drugs in R&D, Vol 24, Iss 1, Pp 1-12 (2024)

Abstract Superficial infections with Streptococcus pyogenes (Strep A), pharyngitis and impetigo can induce acute rheumatic fever, an autoimmune sequela manifesting mostly with arthritis and rheumatic carditis. Valvular heart damage can persist or adv

Externí odkaz: https://doaj.org/article/23154e1095a44ff6b94abfb25a71616c

Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain

Autor: Elisabetta Cerbai, Francesco Resta, Michele Melchiorre, Martina Del Lungo, Laura Sartiani, Leonardo Di Cesare Mannelli, Valentina Spinelli, Carla Ghelardini, Guido Mannaioni, Annunziatina Laurino, Raffaele Coppini, Maria Novella Romanelli, L. Dini

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)
Frontiers in Pharmacology
Frontiers in Pharmacology, 9, 1252. Switzerland: Frontiers Media S.A (2018).

A prominent role of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels has been suggested based on their expression and (dys)function in dorsal root ganglion (DRG) neurons, being likely involved in peripheral nociception. Using HCN b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee587793104ae96826a659e3b3e0b071
https://www.frontiersin.org/article/10.3389/fphar.2018.01252/full