Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Leonardo D. Garma"'
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Epigenetic clocks are mathematical models used to estimate epigenetic age based on DNA methylation at specific CpG sites. As new methylation microarrays are developed and older models discontinued, existing epigenetic clocks might
Externí odkaz:
https://doaj.org/article/909b756f584e409aaffba6fe7b5e7397
Autor:
Josep Argerich, Leonardo D. Garma, Marc López-Cano, Paula Álvarez-Montoya, Laura Gómez-Acero, Víctor Fernández-Dueñas, Ana B. Muñoz-Manchado, Ester Aso, Adam Boxer, Pol Andres-Benito, Per Svenningsson, Francisco Ciruela
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract The orphan G protein-coupled receptor 37 (GPR37), widely associated with Parkinson’s disease (PD), undergoes proteolytic processing under physiological conditions. The N-terminus domain is proteolyzed by a disintegrin and metalloproteinase
Externí odkaz:
https://doaj.org/article/a895c98065b346d388ea55c3a8f58e0d
Autor:
Leonardo D. Garma, Lisbeth Harder, Juan M. Barba-Reyes, Sergio Marco Salas, Mónica Díez-Salguero, Mats Nilsson, Alberto Serrano-Pozo, Bradley T. Hyman, Ana B. Muñoz-Manchado
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Deciphering the striatal interneuron diversity is key to understanding the basal ganglia circuit and to untangling the complex neurological and psychiatric diseases affecting this brain structure. We performed snRNA-seq and spatial transcrip
Externí odkaz:
https://doaj.org/article/728e375820ee48959c617e3c85e173d2
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract COVID-19 is associated with an increased risk of thrombotic events. However, the pathogenesis of these complications is unclear and reports on platelet infection and activation by the virus are conflicting. Here, we integrated single-cell tr
Externí odkaz:
https://doaj.org/article/0b92ac6314984787bfcffcfaa285f6db
Autor:
Leonardo D. Garma, Lisbeth Harder, Juan M. Barba-Reyes, Mónica Díez-Salguero, Alberto Serrano-Pozo, Bradley T. Hyman, Ana B. Muñoz-Manchado
Deciphering the striatal interneuron diversity is key to understanding the basal ganglia circuit and to untangle the complex neurological and psychiatric diseases affecting this brain structure. We performed single-nucleus RNA-sequencing (snRNA-seq)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98f0352b020dad6e25d2352fcaad8791
https://doi.org/10.1101/2023.03.22.533839
https://doi.org/10.1101/2023.03.22.533839
Autor:
Karishma Jain, Zhen Wang, Leonardo D. Garma, Emile Engel, Göksu Cinar Ciftci, Cecilia Fager, Per A. Larsson, Lars Wågberg
Publikováno v:
Applied Materials Today. 30:101703
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aa15f72f5615c9ff6e1e780d6b4acaa
https://doi.org/10.1016/j.apmt.2022.101703
https://doi.org/10.1016/j.apmt.2022.101703
Publikováno v:
Journal of Materials Chemistry B. 6:7096-7101
Bioelectronic platforms can be used for electrophysiology, monitoring and stimulating specific cellular functions. While planar electroactive materials have been extensively used, in the past decade new approaches have focused on engineering the inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e131a6a82719e19793a3b51e55d6ab1e
https://doi.org/10.1039/c8tb01737a
https://doi.org/10.1039/c8tb01737a
Publikováno v:
Lab on a chip. 19(22)
Multi-electrode arrays (MEAs) have become a key element in the study of cellular phenomena in vitro. Common modern MEAs are still based on costly microfabrication techniques, making them expensive tools that researchers are pushed to reuse, compromis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e440215d38680e7fcaff97d3116b61e4
https://pubmed.ncbi.nlm.nih.gov/31616896
https://pubmed.ncbi.nlm.nih.gov/31616896
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:1728-1747
A total of six different structural alignment tools (TM-Align, TriangleMatch, CLICK, ProBis, SiteEngine and GA-SI) were assessed for their ability to perform two particular tasks: (i) discriminating FAD (flavin adenine dinucleotide) from non-FAD bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::231b9d43c1bc06ddf5bd79e91f5a1a25
https://doi.org/10.1002/prot.25158
https://doi.org/10.1002/prot.25158
Autor:
André H. Juffer, Leonardo D. Garma
Publikováno v:
Computational Biology and Chemistry. 61:23-38
HighlightsThe vast majority of binding sites for small ligands are shown to be set of sparsely distributed amino-acids.A method for the comparison of non-sequential protein segments based on a genetic algorithm is introduced.The sequence-independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2e3d269603ef30871dc70f9df8e3ea
https://doi.org/10.1016/j.compbiolchem.2015.12.004
https://doi.org/10.1016/j.compbiolchem.2015.12.004