Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leonardo D Estrada"'
Autor:
Leonardo D Estrada, Didem Ağaç Çobanoğlu, Aaron Wise, Robert W Maples, Murat Can Çobanoğlu, J David Farrar
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272017 (2022)
Norepinephrine is a key sympathetic neurotransmitter, which acts to suppress CD8 + T cell cytokine secretion and lytic activity by signaling through the β2-adrenergic receptor (ADRB2). Although ADRB2 signaling is considered generally immunosuppressi
Externí odkaz:
https://doaj.org/article/7e3c7d103c1b486a8a94b091a186becd
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92187 (2014)
CD8+ cytotoxic T lymphocytes (CTLs) play a major role in defense against intracellular pathogens. During development, antigen-presenting cells secrete innate cytokines such as IL-12 and IFN-α, which drive CTL differentiation into diverse populations
Externí odkaz:
https://doaj.org/article/e75e0cb837b342f4928fb3beb1de54d6
Autor:
Rebekah Honce, Jeremy Jones, Victoria A. Meliopoulos, Brandi Livingston, Bridgett Sharp, Leonardo D. Estrada, Lindsey Wang, William Caulfield, Burgess Freeman, Elena Govorkova, Stacey Schultz-Cherry
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Obesity has been epidemiologically and empirically linked with more severe diseases upon influenza infection. To ameliorate severe disease, treatment with antivirals, such as the neuraminidase inhibitor oseltamivir, is suggested to begin wit
Externí odkaz:
https://doaj.org/article/0a1998aea44d44c3a86371144b0ad70c
Autor:
Rebekah Honce, Erik A. Karlsson, Nicholas Wohlgemuth, Leonardo D. Estrada, Victoria A. Meliopoulos, Jiangwei Yao, Stacey Schultz-Cherry
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Obesity is associated with increased disease severity, elevated viral titers in exhaled breath, and significantly prolonged viral shed during influenza A virus infection. Due to the mutable nature of RNA viruses, we questioned whether obesit
Externí odkaz:
https://doaj.org/article/0f8be709e91242ec8528399106fc710e
Autor:
Bridgett Sharp, Pedro Jimenez-Bluhm, Jiangwei Yao, Stacey Schultz-Cherry, Pamela Freiden, Victoria A. Meliopoulos, Brandi Livingston, Amy Davis, Christopher Hamilton-West, Angela Danner, Nicolas Bravo-Vasquez, Sean Cherry, Leonardo D. Estrada
Publikováno v:
Emerging Infectious Diseases
Emerging Infectious Diseases, Vol 26, Iss 12, Pp 2887-2898 (2020)
Emerging Infectious Diseases, Vol 26, Iss 12, Pp 2887-2898 (2020)
Since their discovery in the United States in 1963, outbreaks of infection with equine influenza virus (H3N8) have been associated with serious respiratory disease in horses worldwide. Genomic analysis suggests that equine H3 viruses are of an avian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a39cb9c6d7ec4ccb5b4113c7c3f9431
http://europepmc.org/articles/PMC7706983
http://europepmc.org/articles/PMC7706983
Autor:
Lu Wang, Elena A. Govorkova, Burgess B. Freeman, Brandi Livingston, Leonardo D. Estrada, Jeremy C. Jones, Stacey Schultz-Cherry, Caulfield W, Rebekah Honce
Obesity has been epidemiologically and empirically linked with more severe disease upon influenza infection. To ameliorate severe disease, treatment with antivirals, such as the neuraminidase inhibitor oseltamivir, are suggested to begin within days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c510663fc7a54b26ea1e11caa2b3c2c
https://doi.org/10.1101/2021.04.28.441903
https://doi.org/10.1101/2021.04.28.441903
Publikováno v:
Brain, Behavior, and Immunity. 74:176-185
The mammalian nervous system communicates important information about the environment to the immune system, but the underlying mechanisms are largely unknown. Secondary lymphoid organs are highly innervated by sympathetic neurons that secrete norepin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97da13c41af84fceec1e259778c70e1f
https://doi.org/10.1016/j.bbi.2018.09.004
https://doi.org/10.1016/j.bbi.2018.09.004
Publikováno v:
European Journal of Immunology. 46:1948-1958
Postganglionic sympathetic neurons innervate secondary lymphoid organs and secrete norepinephrine (NE) as the primary neurotransmitter. NE binds and signals through five distinct members of the adrenergic receptor family. In this study, we show eleva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec5f020bbcb4ce992c1cf4d461b41b6
https://doi.org/10.1002/eji.201646395
https://doi.org/10.1002/eji.201646395
Publikováno v:
European Journal of Immunology. 46:1504-1510
Type I interferon (IFN-α/β) plays a critical role in suppressing viral replication by driving the transcription of hundreds of interferon-sensitive genes (ISGs). While many ISGs are transcriptionally activated by the ISGF3 complex, the significance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d8bcc0508d1279eccd5493d28c610c4
https://doi.org/10.1002/eji.201546050
https://doi.org/10.1002/eji.201546050
Publikováno v:
The Journal of Immunology. 204:245.16-245.16
Fifty percent of the United States population is predicted to be obese (body mass index > 30) by 2030. Obese individuals are considered a high-risk group for developing severe influenza disease. To compound this, studies have shown that inactivated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8148a4640458fe0c0f8236297396de2
https://doi.org/10.4049/jimmunol.204.supp.245.16
https://doi.org/10.4049/jimmunol.204.supp.245.16