Výsledky vyhledávání - "Leonardo Campos Zanelatto"

Akademický článek

LNO3 AND L3 Are Associated With Antiproliferative And Pro-Apoptotic Action In Hepatoma Cells

Autor: Leonardo Campos Zanelatto, Patrícia Benites Gonçalves da Silva, Daniele Sartori, Carolina Panis, Sandra Lepri, Ângelo de Fátima, Mário Sérgio Mantovani

Publikováno v: Genetics and Molecular Biology, Vol 39, Iss 2, Pp 270-278 (2016)

Abstract The identification of antitumoral substances is the focus of intense biomedical research. Two structural analogues of thalidomide, LNO3 and L3, are two synthetic compounds that might possess such antitumor properties. We evaluated the toxico

Externí odkaz: https://doaj.org/article/bf17a3a9b141488e9972848cc885174c

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Dissertation/ Thesis

Ação quimioprotetora do micronutriente Selênio em células HepG2 : avaliação da expressão de genes de estresse celular induzido por H2O2

Autor: Leonardo Campos Zanelatto

Publikováno v: Biblioteca Digital de Teses e Dissertações da UELUniversidade Estadual de LondrinaUEL.

Dentre diferentes agentes analisados quanto ao potencial quimioprotetor para o câncer, os componentes da dieta são os mais bem avaliados. Tais estudos apresentam evidências de que os alimentos fornecem substâncias bioativas que podem alterar a ex

Externí odkaz: http://www.bibliotecadigital.uel.br/document/?code=vtls000193602

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Expressão do RNA telomérico não-codificante TERRA em leucemias agudas e telomeropatias

Autor: Leonardo Campos Zanelatto

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

Telômeros são estruturas que possuem como função proteger as extremidades dos cromossomos lineares e manter a integridade genômica. Mutações constitutivas que interferem nos mecanismos de manutenção do comprimento dos telômeros podem levar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97dbebadd98e33df9340c39b06875687
https://doi.org/10.11606/t.17.2019.tde-06092019-144820

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Effects chronic administration of corticosterone and estrogen on HPA axis activity and telomere length in brain areas of female rats

Autor: Celso Rodrigues Franci, Barbara A. Santana, Rodrigo T. Calado, Procópio Cleber Gama de Barcellos Filho, Leonardo Campos Zanelatto

Publikováno v: Brain Research. 1750:147152

Chronic stress is related to the acceleration of telomere shortening. Recent work showed a correlation between chronic psychosocial stress and reduced telomere length in certain cells. The exposure of T lymphocytes to cortisol promoted a significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654ec79bc9c0d553866245d603f5ca27
https://doi.org/10.1016/j.brainres.2020.147152

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The effects of genistein and daidzein on cell proliferation kinetics in HT29 colon cancer cells: the expression of CTNNBIP1 (β-catenin), APC (adenomatous polyposis coli) and BIRC5 (survivin)

Autor: Mário Sérgio Mantovani, Patrícia Benites Gonçalves da Silva, Daniele Sartori, Sandra Regina Lepri, Lúcia Regina Ribeiro, Leonardo Campos Zanelatto

Publikováno v: Human Cell. 27:78-84

Soybean isoflavonoids have received significant attention due to their potential anticarcinogenic and antiproliferative effects and possible role in many signal transduction pathways. However, their mechanisms of action and their molecular targets re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc258059a6a27862ead19046cf7ada94
https://doi.org/10.1007/s13577-012-0051-6

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Chemoprotective action of l-(+)-selenomethionine on the modulation of genes involved in oxidative stress and in the UPR pathway

Autor: Mário Sérgio Mantovani, Daniele Sartori, Sandra Regina Lepri, Leonardo Campos Zanelatto

Publikováno v: European Food Research and Technology. 237:765-773

The installation of oxidative process arises from an imbalance between oxidants and antioxidants compounds, in favor of excessive generation of free radicals. This process can affect cellular components, like endoplasmic reticulum (ER). The ER is ext

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2ae878df1c3647652fbbd172dce5eec
https://doi.org/10.1007/s00217-013-2049-z

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LNO3 AND L3 Are Associated With Antiproliferative And Pro-Apoptotic Action In Hepatoma Cells

Autor: Carolina Panis, Sandra Regina Lepri, Daniele Sartori, Leonardo Campos Zanelatto, Ângelo de Fátima, Patrícia Benites Gonçalves da Silva, Mário Sérgio Mantovani

Publikováno v: Genetics and Molecular Biology v.39 n.2 2016
Genetics and Molecular Biology
Sociedade Brasileira de Genética (SBG)
instacron:SBG
Genetics and Molecular Biology, Vol 39, Iss 2, Pp 270-278 (2016)
Genetics and Molecular Biology, Volume: 39, Issue: 2, Pages: 270-278, Published: JUN 2016

The identification of antitumoral substances is the focus of intense biomedical research. Two structural analogues of thalidomide, LNO3 and L3, are two synthetic compounds that might possess such antitumor properties. We evaluated the toxicological e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721b520670135d95f774f37f075ffa6d
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000200270

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Chemoprotective action of the micronutrient selenium in HepG2 cells: gene expression evaluation of cellular stress induced by H2O2

Autor: Leonardo Campos Zanelatto

Publikováno v: Biblioteca Digital de Teses e Dissertações da UEL
Universidade Estadual de Londrina (UEL)
instacron:UEL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::1c9d0f194150227ada78c29f3ebcf0c5
http://www.bibliotecadigital.uel.br/document/?code=vtls000193602

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Chemoprotective activity of the isoflavones, genistein and daidzein on mutagenicity induced by direct and indirect mutagens in cultured HTC cells

Autor: Sandra Regina Lepri, Rodrigo Cabral Luiz, Lúcia Regina Ribeiro, Patrícia Benites Gonçalves da Silva, Daniele Sartori, Mário Sérgio Mantovani, Leonardo Campos Zanelatto

Publikováno v: Cytotechnology. 65(2)

Isoflavones are phenolic compounds widely distributed in plants and found in a high percentage in soybeans. They have important biological properties and are regarded as potential chemopreventive agents. The aim of this study was to verify the preven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b26935af39995dd3a1b7c19f1c5b7df
https://pubmed.ncbi.nlm.nih.gov/22752585

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In vivophotothermal tumour ablation using gold nanorods

Autor: Virginia da Conceição Amaro Martins, Clovis Grecco, Leonardo Campos Zanelatto, Mário Sérgio Mantovani, Cristina Kurachi, Ana Maria de Guzzi Plepis, R Ceccini, Patrícia Benites Gonçalves da Silva, L F de Freitas, Lilian Tan Moriyama

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Less invasive and more effective cancer treatments have been the aim of research in recent decades, e.g. photothermal tumour ablation using gold nanorods. In this study we investigate the cell death pathways activated, and confirm the possibility of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76eba4cb3c6251edc6cc012c85c9cde0
https://doi.org/10.1088/1054-660x/23/6/066003

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