Insights into the Substrate Uptake Mechanism of Mycobacterium Tuberculosis Ribose 5-Phosphate Isomerase and Perspectives on Drug Development

Autor: Leonardo Bartkevihi, Ícaro P. Caruso, Bruna Martins, José R. M. Pires, Danielle M. P. Oliveira, Cristiane Dinis Anobom, Fabio C. L. Almeida

Publikováno v: Biophysica, Vol 3, Iss 1, Pp 139-157 (2023)

The active site of the dimeric ribose 5-phosphate isomerase B (RpiB) contains a solvent-exposed barrier formed by residues H12, R113, R137, and R141, which is closed upon the complexation of phosphate. The substrate ribose 5-phosphate (R5P) has to ov

Externí odkaz: https://doaj.org/article/b2d1450f87724db8880684554c44bac8

Backbone assignment of ribose-5-phosphate isomerase of Mycobacterium tuberculosis (MtRpiB)

Autor: Bruna Maria de Carvalho Martins, Danielle M.P. Oliveira, Cristiane D. Anobom, Leonardo Bartkevihi, Fabio C. L. Almeida, José R. Pires

Publikováno v: Biomolecular NMR Assignments. 14:119-122

Tuberculosis is one of the deadliest diseases worldwide affecting approximately 10 million people in 2018. This classifies tuberculosis as epidemic in several countries and leads to an increasing number of multidrug-resistant strains. Thus, the devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4263f70bab053353096e7a44c4d9847c
https://doi.org/10.1007/s12104-020-09931-0

Structure insights, thermodynamic profiles, dsDNA melting activity, and liquid-liquid phase separation of the SARS-CoV-2 nucleocapsid N-terminal domain binding to DNA

Autor: Thais Cristtina Neves-Martins, Aline de Luna Marques, Gabriela R. Araujo, Mariana J. do Amaral, Isabella Otenio de Lourenço, Vitor S. Almeida, Ícaro Putinhon Caruso, Francisco Gomes-Neto, Guilherme Caldas Andrade, Andrea T. Da Poian, Talita S. Araujo, Glauce M. Barbosa, Karoline Sanches, Ariana A. Vasconcelos, Clara L. F. Malizia-Motta, Katia M. S. Cabral, Peter Reis Bezerra, Marcos Caique Santana-Silva, Nathane C. Mebus-Antunes, Jessica M. Azevedo, Cristiane D. Anobom, Leonardo Bartkevihi, Gisele Cardoso Amorim, Fabio C. L. Almeida, Jessica M. Sa, Anderson S. Pinheiro, Marcius S. Almeida

The SARS-CoV-2 nucleocapsid protein (N) is a multifunctional promiscuous nucleic acid-binding protein, which plays a major role in nucleocapsid assembly and discontinuous RNA transcription, facilitating the template switch of transcriptional regulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ba4092d34b6208964bdc927921ac0ff
https://doi.org/10.1101/2021.07.21.453232

Backbone assignment of ribose-5-phosphate isomerase of Mycobacterium tuberculosis (MtRpiB)

Autor: Leonardo, Bartkevihi, Bruna, Martins, Danielle Maria Perpétua, de Oliveira, José Ricardo M, Pires, Cristiane Dinis, Anobom, Fabio C L, Almeida

Publikováno v: Biomolecular NMR assignments. 14(1)

Tuberculosis is one of the deadliest diseases worldwide affecting approximately 10 million people in 2018. This classifies tuberculosis as epidemic in several countries and leads to an increasing number of multidrug-resistant strains. Thus, the devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ea3c5a6755322c23d5250e1d169bd45
https://pubmed.ncbi.nlm.nih.gov/32030620

¹⁵ N, ¹³ C, and ¹ H resonance assignments of Jarastatin: a disintegrin of Bothrops jararaca.

Autor: Vasconcelos AA; Institute of Medical Biochemistry (IBqM) Leopoldo de Meis, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; National Center of Nuclear Magnetic Resonance (CNRMN), Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Succar BB; Laboratório de Hemostase e Venenos, Institute of Medical Biochemistry Leopoldo de Meis (IBqM), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., di Piero LB; Institute of Medical Biochemistry (IBqM) Leopoldo de Meis, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; National Center of Nuclear Magnetic Resonance (CNRMN), Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Kurtenbach E; Laboratório de Biologia Molecular e Bioquímica de Proteínas (LBMBP), Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Zingali RB; Laboratório de Hemostase e Venenos, Institute of Medical Biochemistry Leopoldo de Meis (IBqM), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. lzingali@bioqmed.ufrj.br., Almeida FCL; Institute of Medical Biochemistry (IBqM) Leopoldo de Meis, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. falmeida@bioqmed.ufrj.br.; National Center of Nuclear Magnetic Resonance (CNRMN), Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. falmeida@bioqmed.ufrj.br.

Publikováno v: Biomolecular NMR assignments [Biomol NMR Assign] 2022 Apr; Vol. 16 (1), pp. 37-40. Date of Electronic Publication: 2021 Nov 26.