Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease

Autor: Nadia Rosenberg, Maria Reva, Francesca Binda, Leonardo Restivo, Pauline Depierre, Julien Puyal, Marc Briquet, Yann Bernardinelli, Anne‐Bérengère Rocher, Henry Markram, Jean‐Yves Chatton

Publikováno v: Glia, vol. 71, no. 4, pp. 957-973

Alzheimer's disease (AD) is becoming increasingly prevalent worldwide. It represents one of the greatest medical challenges as no pharmacologic treatments are available to prevent disease progression. Astrocytes play crucial functions within neuronal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f55053e7a0339af69a3954befb63d9
https://doi.org/10.1002/glia.24317

Autophagy in parvalbumin interneurons is required for inhibitory transmission and memory via regulation of synaptic proteostasis

Autor: Theodora Chalatsi, Laura M.J. Fernandez, Jules Scholler, Laura Batti, Angeliki Kolaxi, Leonardo Restivo, Anita Lüthi, Manuel Mameli, Vassiliki Nikoletopoulou

Publikováno v: Biorxiv
bioRxiv

SummaryWith the emerging role of the autophagic machinery in healthy brain development and aging, there is a pressing need to better characterize its functions in different neuronal populations, providing cellular insight into autophagy-related brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78f47becb98b1c76ec0d26632007216
https://doi.org/10.1101/2022.10.10.511533

A neural substrate for negative affect dictates parental behaviour

Autor: Salvatore Lecca, Mauro Congiu, Lea Royon, Leonardo Restivo, Benoit Girard, Noemie Mazare, Camilla Bellone, Ludovic Telley, Manuel Mameli

Parental behaviours are essential to secure survival and wellbeing of newborns1. Concomitantly, parenting also limits negative affective states in adults, which emerge when the coping with excessive neonatal distress becomes a challenge1–5. Whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::531106288ba47199351a543c60190b10
https://doi.org/10.21203/rs.3.rs-1461765/v1

Towards best practices in research Role of academic core facilities

Autor: Leonardo, Restivo, Björn, Gerlach, Michael, Tsoory, Lior, Bikovski, Sylvia, Badurek, Claudia, Pitzer, Isabelle C, Kos-Braun, Anne-Laure Mj, Mausset-Bonnefont, Jonathan, Ward, Michael, Schunn, Lucas Pjj, Noldus, Anton, Bespalov, Vootele, Voikar

Publikováno v: EMBO Reports
EMBO Reports, EMBO Press, 2021, ⟨10.15252/embr.202153824⟩
EMBO Reports, EMBO Press, 2021, 22, pp.e53824. ⟨10.15252/embr.202153824⟩
EMBO reports, vol. 22, no. 12, pp. e53824

International audience; Academic Core Facilities are optimally situated to improve the quality of preclinical research by implementing quality control measures and offering these to their users.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::09ef8a28ebad977236993d5f346766e2
http://hdl.handle.net/10138/337670

Introduction to the EQIPD quality system

Autor: Lior Bikovski, Raafat Fares, Anton Bespalov, Claudia Kurreck, Leonardo Restivo, Paul Moser, Chantelle Ferland-Beckham, Claudia Stöger, Patricia Kabitzke, Ernesto Prado Montes de Oca, Bruce Altevogt, Valerie Gailus-Durner, Sabine M. Hölter, Piotr Popik, Martine C J Hofmann, Vootele Voikar, Lee Monk, Michael Schunn, Alexander Dityatev, Janko Samardzic, Gernot Riedel, Thomas Steckler, Natasja de Bruin, Merel Ritskes-Hoitinga, Kathleen Wuyts, Christoph H. Emmerich, Heidrun Potschka, Vincent Castagné, Christelle Froger-Colléaux, Fiona Ducrey, Anja Gilis, Björn Gerlach, Jan Vollert, Kimberley E. Wever, Sandrine Bongiovanni, Esmeralda Castaños-Vélez, Martien J H Kas, René Bernard, Malcolm R. Macleod, Isabel A Lefevre, Javier Guillén, Małgorzata Pietraszek, María Arroyo-Araujo, Ulrich Dirnagl

Publikováno v: Bespalov, A, Bernard, R, Gilis, A, Gerlach, B, Guillén, J, Castagné, V, Lefevre, I A, Ducrey, F, Monk, L, Bongiovanni, S, Altevogt, B, Arroyo-araujo, M, Bikovski, L, De Bruin, N, Castaños-vélez, E, Dityatev, A, Emmerich, C H, Fares, R, Ferland-beckham, C, Froger-colléaux, C, Gailus-durner, V, Hölter, S M, Hofmann, M C, Kabitzke, P, Kas, M J, Kurreck, C, Moser, P, Pietraszek, M, Popik, P, Potschka, H, Prado Montes De Oca, E, Restivo, L, Riedel, G, Ritskes-hoitinga, M, Samardzic, J, Schunn, M, Stöger, C, Voikar, V, Vollert, J, Wever, K E, Wuyts, K, Macleod, M R, Dirnagl, U & Steckler, T 2021, ' Introduction to the EQIPD quality system ', eLIFE, vol. 10 . https://doi.org/10.7554/eLife.63294
eLife, 10:e63294. ELIFE SCIENCES PUBLICATIONS LTD
eLife, Vol 10 (2021)
eLife 10, e63294 (2021). doi:10.7554/eLife.63294
eLife
Elife, 10
Bespalov, A, Bernard, R, Gilis, A, Gerlach, B, Guillén, J, Castagné, V, Lefevre, I A, Ducrey, F, Monk, L, Bongiovanni, S, Altevogt, B, Arroyo-Araujo, M, Bikovski, L, de Bruin, N, Castaños-Vélez, E, Dityatev, A, Emmerich, C H, Fares, R, Ferland-Beckham, C, Froger-Colléaux, C, Gailus-Durner, V, Hölter, S M, Hofmann, M C, Kabitzke, P, Kas, M J, Kurreck, C, Moser, P, Pietraszek, M, Popik, P, Potschka, H, Prado Montes de Oca, E, Restivo, L, Riedel, G, Ritskes-Hoitinga, M, Samardzic, J, Schunn, M, Stöger, C, Voikar, V, Vollert, J, Wever, K E, Wuyts, K, MacLeod, M R, Dirnagl, U & Steckler, T 2021, ' Introduction to the EQIPD quality system ', eLife, vol. 10, e63294 . https://doi.org/10.7554/eLife.63294
eLife, vol. 10, pp. e63294

While high risk of failure is an inherent part of developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Numerous analyses conducted to date have clearly identified measures that need to be take

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aef7c0ead5b242adb59f95192215766
http://hdl.handle.net/10044/1/95909