Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Leonardo, De Maria"'
Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids
Autor:
Marc Oeller, Ryan J. D. Kang, Hannah L. Bolt, Ana L. Gomes dos Santos, Annika Langborg Weinmann, Antonios Nikitidis, Pavol Zlatoidsky, Wu Su, Werngard Czechtizky, Leonardo De Maria, Pietro Sormanni, Michele Vendruscolo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Non-natural amino acids are increasingly used as building blocks in the development of peptide-based drugs as they expand the available chemical space to tailor function, half-life and other key properties. However, while the chemical space
Externí odkaz:
https://doaj.org/article/0caac934400240c99334cfb366d281f4
Autor:
Martina Audagnotto, Werngard Czechtizky, Leonardo De Maria, Helena Käck, Garegin Papoian, Lars Tornberg, Christian Tyrchan, Johan Ulander
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Proteins exist in several different conformations. These structural changes are often associated with fluctuations at the residue level. Recent findings show that co-evolutionary analysis coupled with machine-learning techniques improves the
Externí odkaz:
https://doaj.org/article/b4c9c7ebb49846d4817aa2ca4fe5a969
Autor:
Marc Oeller, Ryan Kang, Hannah Bolt, Ana Gomes dos Santos, Annika Weinmann, Antonios Nikitidis, Pavol Zlatoidsky, Wu Su, Werngard Czechtizky, Leonardo De Maria, Pietro Sormanni, Michele Vendruscolo
Non-natural amino acids are increasingly used as building blocks in the development of peptide-based drugs, as they expand the available chemical space to tailor function, half-life and other key properties. However, while the chemical space of modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913c783091f3d950032faa294f743e80
https://doi.org/10.1101/2023.03.03.530952
https://doi.org/10.1101/2023.03.03.530952
Autor:
Tina M. Tagmose, Karen-Margrethe Pedersen, Lone Pridal, Carsten E. Stidsen, Marie Ø. Pedersen, Zhaosheng Lin, Yuanyuan Zhang, Zhe Wan, Mercedes Ferreras, Helle Naver, Peter K. Nielsen, Zheng Cao, Yi Wang, Lennart Lykke, Josefine L. Christensen, Victoria S. Jensen, Valentina Manfè, Thomas Å. Pedersen, Eva Johansson, Peter Madsen, János T. Kodra, Martin Münzel, Leonardo De Maria, Erica Nishimura, Thomas B. Kjeldsen
Publikováno v:
Journal of Medicinal Chemistry. 65:2633-2645
Here, we describe molecular engineering of monovalent ultra-long acting two-chain insulin-Fc conjugates. Insulin-Fc conjugates were synthesized using trifunctional linkers with one amino reactive group for reaction with a lysine residue of insulin an
Publikováno v:
Barker, R, Yu, Y, De Maria, L, Johannissen, L & Scrutton, N 2022, ' The Mechanism of Action of Flavin-Dependent Halogenases ', ACS Catalysis, vol. 12, no. 24, pp. 15352–15360 . https://doi.org/10.1021/acscatal.2c05231
To rationally engineer the substrate scope and selectivity of flavin-dependent halogenases (FDHs), it is essential tofirst understand the reaction mechanism and substrate interactions in the active site. FDHs have long been known to achieve regiosele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2964263daae6a95a0b7c946fce4256ed
https://research.manchester.ac.uk/en/publications/e180df19-f56e-490f-a62d-b58a3ddbc170
https://research.manchester.ac.uk/en/publications/e180df19-f56e-490f-a62d-b58a3ddbc170
Autor:
Yuqi Yu, Arnau Rue Casamajo, William Finnigan, Christian Schnepel, Rhys Barker, Charlotte Morrill, Rachel Heath, Leonardo De Maria, Nicholas Turner, Nigel Scrutton
Biocatalysis is emerging as an attractive option for manufacturing pharmaceuticals. However, the identification of enzymes for target transformations of interest requires major screening efforts. Here we report a structure-based computational workflo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63d03eee9a4e3cc6110767098d3c33f
https://doi.org/10.26434/chemrxiv-2022-vz6gd
https://doi.org/10.26434/chemrxiv-2022-vz6gd
Autor:
Edward J. Taylor, Michael Skjøt, Lars K. Skov, Mikkel Klausen, Leonardo De Maria, Garry P. Gippert, Johan P. Turkenburg, Gideon J. Davies, Keith S. Wilson
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5531 (2019)
Muramidases/lysozymes are important bio-molecules, which cleave the glycan backbone in the peptidoglycan polymer found in bacterial cell walls. The glycoside hydrolase (GH) family 22 C-type lysozyme, from the folivorous bird Opisthocomus hoazin (stin
Externí odkaz:
https://doaj.org/article/5fecf9cd6a5d4422ae6192651fc183ca
Autor:
Søs Torpenholt, Leonardo De Maria, Mats H.M. Olsson, Lars H. Christensen, Michael Skjøt, Peter Westh, Jan H. Jensen, Leila Lo Leggio
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 256-264 (2015)
New variants of β-1,4-galactanase from the mesophilic organism Aspergillus aculeatus were designed using the structure of β-1,4-galactanase from the thermophile organism Myceliophthora thermophila as a template. Some of the variants were generated
Externí odkaz:
https://doaj.org/article/6c7b7132f22c4d28a02f5c027d0aec33
Autor:
Frank Wesche, Leonardo De Maria, Tomas Leek, Frank Narjes, James Bird, Wu Su, Werngard Czechtizky
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 224
Peptides and peptide drug conjugates are emerging modalities to treat pulmonary diseases. Peptides are susceptible to proteolytic cleavage. Expression levels of specific proteases in the lung can be significantly increased in disease state and may le
Autor:
Kosala N. Amarasinghe, Leonardo De Maria, Christian Tyrchan, Leif A. Eriksson, Jens Sadowski, Dušan Petrović
Publikováno v:
Journal of chemical information and modeling. 62(12)
Peptides are an important modality in drug discovery. While current peptide optimization focuses predominantly on the small number of natural and commercially available non-natural amino acids, the chemical spaces available for small molecule drug di