Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Leonardo, Brustolin"'
1
Akademický článek
Binuclear Heteroleptic Ru(III) Dithiocarbamate Complexes: A Step towards Tunable Antiproliferative Agents
Autor: Andrea E. Gallio, Leonardo Brustolin, Nicolò Pettenuzzo, Dolores Fregona
Publikováno v: Inorganics, Vol 10, Iss 3, p 37 (2022)
Binuclear dithiocarbamate complexes of Ru(III) are promising candidates in the search for outstanding metal-based anticancer agents. While different dithiocarbamates have shown ligand-dependent cytotoxicity in homoleptic binuclear Ru(III) complexes,
Externí odkaz: https://doaj.org/article/2c9417ad22ac41549d9b641445ed082e
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2
Akademický článek
Gold(III) to Ruthenium(III) Metal Exchange in Dithiocarbamato Complexes Tunes Their Biological Mode of Action for Cytotoxicity in Cancer Cells
Autor: Maria Dalla Pozza, Christophe Orvain, Leonardo Brustolin, Nicolò Pettenuzzo, Chiara Nardon, Christian Gaiddon, Dolores Fregona
Publikováno v: Molecules, Vol 26, Iss 13, p 4073 (2021)
Malignant tumors have affected the human being since the pharaoh period, but in the last century the incidence of this disease has increased due to a large number of risk factors, including deleterious lifestyle habits (i.e., smoking) and the higher
Externí odkaz: https://doaj.org/article/939376302eae4ffbb2670cac01a8bc13
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3
CuIIand AuIIIComplexes with Glycoconjugated Dithiocarbamato Ligands for Potential Applications in Targeted Chemotherapy
Autor: Alberto Gambalunga, Federica Chiara, Barbara Biondi, Dolores Fregona, Chiara Nardon, Leonardo Brustolin, Andrea Trevisan, Nicolò Pettenuzzo, Elisa Coltri
Publikováno v: ChemMedChem
14 (2019): 1162–1172. doi:10.1002/cmdc.201900226
info:cnr-pdr/source/autori:Pettenuzzo, Nicolo; Brustolin, Leonardo; Coltri, Elisa; Gambalunga, Alberto; Chiara, Federica; Trevisan, Andrea; Biondi, Barbara; Nardon, Chiara; Fregona, Dolores/titolo:Cu-II and Au-III Complexes with Glycoconjugated Dithiocarbamato Ligands for Potential Applications in Targeted Chemotherapy/doi:10.1002%2Fcmdc.201900226/rivista:ChemMedChem (Print)/anno:2019/pagina_da:1162/pagina_a:1172/intervallo_pagine:1162–1172/volume:14
This work is focused on the synthesis, characterization, and preliminary biological evaluation of bio-conjugated Au-III and Cu-II complexes with the aim of overcoming the well-known side effects of chemotherapy by improving the selective accumulation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578f3bccb791ec0d0cf39e8b20c9a839
https://doi.org/10.1002/cmdc.201900226
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4
Au(iii)-Proline derivatives exhibiting selective antiproliferative activity against HepG2/SB3 apoptosis-resistant cancer cells
Autor: Nicolò Pettenuzzo, Santina Quarta, Patrizia Pontisso, Dolores Fregona, Luciano Marchiò, Barbara Biondi, Chiara Nardon, Leonardo Brustolin
Publikováno v: Dalton transactions (2003. Online) 48 (2019): 16017–16025. doi:10.1039/c9dt03036k
info:cnr-pdr/source/autori:Brustolin L.; Pettenuzzo N.; Nardon C.; Quarta S.; Marchio L.; Biondi B.; Pontisso P.; Fregona D./titolo:Au(iii)-Proline derivatives exhibiting selective antiproliferative activity against HepG2%2FSB3 apoptosis-resistant cancer cells/doi:10.1039%2Fc9dt03036k/rivista:Dalton transactions (2003. Online)/anno:2019/pagina_da:16017/pagina_a:16025/intervallo_pagine:16017–16025/volume:48
This paper deals with the combination of a proline-based moiety with biologically active gold centers in the oxidation states +1 and +3. In particular, six Au(i)/(iii)-proline dithiocarbamato (DTC) complexes with general formulae [Au(DTC)2] and [AuII
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ad537f821181056fc62313ab20abbb
https://doi.org/10.1039/c9dt03036k
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5
Labelled micelles for the delivery of cytotoxic Cu(II) and Ru(III) compounds in the treatment of aggressive orphan cancers: design and biological in vitro data
Autor: Stefano Merigliano, Dolores Fregona, Antonio Rosato, Patrizia Pontisso, Santina Quarta, Chiara Nardon, Nicolò Pettenuzzo, Pierfranco Conte, Isabella Monia Montagner, Leonardo Brustolin
Publikováno v: Università degli Studi di Padova-IRIS
A recent study on our metal-dithiocarbamato complexes pointed out the antiproliferative properties and the druglikeness of some new patented derivatives. In this work, the best compounds have been encapsulated in micellar nanocarriers, being also car
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba52805fdb358a79425c53f82a05cd3f
http://hdl.handle.net/11562/1062969
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6
Cu
Autor: Nicolò, Pettenuzzo, Leonardo, Brustolin, Elisa, Coltri, Alberto, Gambalunga, Federica, Chiara, Andrea, Trevisan, Barbara, Biondi, Chiara, Nardon, Dolores, Fregona
Publikováno v: ChemMedChem. 14(12)
This work is focused on the synthesis, characterization, and preliminary biological evaluation of bio-conjugated Au
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::409ac2e6d02f528b90e813cf4c37aba8
https://pubmed.ncbi.nlm.nih.gov/31091012
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7
Ru(III) anticancer agents with aromatic and non-aromatic dithiocarbamates as ligands: Loading into nanocarriers and preliminary biological studies
Autor: Alberto Gambalunga, Federica Chiara, Simone Scintilla, Leonardo Brustolin, Chiara Nardon, Dolores Fregona, Andrea Trevisan
Publikováno v: Journal of Inorganic Biochemistry. 165:159-169
Since the discovery of cisplatin in the 1960s, other metal complexes have been investigated as potential antitumor agents to overcome the side-effects associated with the administration of the Pt-based drug. In line with our previous research, in thi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa2c343c19b2987b2c4f5c191e02bb6
https://doi.org/10.1016/j.jinorgbio.2016.11.018
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9
Gold(III)-pyrrolidinedithiocarbamato Derivatives as Antineoplastic Agents
Autor: Francesco Ciscato, Alberto Gambalunga, Andrea Rasola, Federica Chiara, Chiara Nardon, Leonardo Brustolin, Dolores Fregona, Andrea Trevisan
Publikováno v: ChemistryOpen
Transition metals offer many possibilities in developing potent chemotherapeutic agents. They are endowed with a variety of oxidation states, allowing for the selection of their coordination numbers and geometries via the choice of proper ligands, le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7244301133e0a9a0a0bb44d56f5e8f5f
http://hdl.handle.net/11577/3192236
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