Výsledky vyhledávání - "Leonarda Troiano"

A Comprehensive Analysis of Cytokine Network in Centenarians

Autor: Marcello Pinti, Lara Gibellini, Domenico Lo Tartaro, Sara De Biasi, Milena Nasi, Rebecca Borella, Lucia Fidanza, Anita Neroni, Leonarda Troiano, Claudio Franceschi, Andrea Cossarizza

Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2719

Cytokines have been investigated extensively in elderly people, with conflicting results. We performed a comprehensive analysis of the plasma levels of 62 cytokines and growth factors involved in the regulation of the immune system, in healthy centen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17db469481cab4167973d766caeddde
https://doi.org/10.3390/ijms24032719

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Characterization of the cell growth inhibitory effects of a novel DNA-intercalating bipyridyl-thiourea-Pt(II) complex in cisplatin-sensitive and—resistant human ovarian cancer cells

Autor: Alessio Ligabue, Maria Giuseppina Monti, Federica I. Wolf, Leonarda Troiano, Stefano Iotti, Monica Montanari, Elena Di Vono, Matteo Cusumano, Gaetano Marverti, Davide Guerrieri, Maria Letizia Di Pietro, Giovanna Farruggia, Chiara Frassineti

Publikováno v: Investigational New Drugs. 29:73-86

The cellular effects of a novel DNA-intercalating agent, the bipyridyl complex of platinum(II) with diphenyl thiourea, [Pt(bipy)(Ph(2)-tu)(2)]Cl(2), has been analyzed in the cisplatin (cDDP)-sensitive human ovarian carcinoma cell line, 2008, and its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13be49e0892be941f2c453db3276064
https://doi.org/10.1007/s10637-009-9336-3

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Quercetin inhibits lymphocyte activation and proliferation without inducing apoptosis in peripheral mononuclear cells

Autor: Lara Gibellini, Leonarda Troiano, Roberta Ferraresi, Elisa Nemes, Milena Nasi, Paolo Salomoni, Edwin L. Cooper, Erika Roat, Linda Bertoncelli, Marcello Pinti, Enrico Lugli, Andrea Cossarizza

Publikováno v: Leukemia Research. 33:140-150

Toxicity of chemotherapeutic drugs towards normal cells is a serious side effect of cancer treatment. Thus, finding of molecules with low toxicity for normal cells is crucial. Several natural compounds, such as flavonoid quercertin, are receiving a g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed908107aa81f51018e312bca201d4b
https://doi.org/10.1016/j.leukres.2008.07.025

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Resistance of mtDNA-depleted cells to apoptosis

Autor: Giuseppe Passarino, Enrico Lugli, Roberta Ferraresi, Leonarda Troiano, Marcello Pinti, Andrea Cossarizza, Daniela Quaglino, Dina Bellizzi, Daniela Taverna, Erika Roat

Publikováno v: Cytometry Part A. :528-537

Cells lacking mitochondrial genome (defined as ρ0) are useful models in studies on cancer, aging, mitochondrial diseases and apoptosis, but several of their functional aspects have been poorly characterized. Using different clones of ρ0 cells deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45aec6c33a9a35f06a8d32bd5cc504a
https://doi.org/10.1002/cyto.a.20544

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Multiparametric analysis of cells with different mitochondrial membrane potential during apoptosis by polychromatic flow cytometry

Autor: Elisa Nemes, Andrea Cossarizza, Enrico Lugli, Erika Roat, Leonarda Troiano, Roberta Ferraresi, Marcello Pinti, Milena Nasi

Publikováno v: Nature Protocols. 2:2719-2727

The analysis of changes in mitochondrial membrane potential (MMP) that can occur during apoptosis provides precious information on the mechanisms and pathways of cell death. For many years, the metachromatic fluorochrome JC-1 (5,5',6,6'-tetrachloro-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f6ce426f5bb2cb71241b66a11d7cc3
https://doi.org/10.1038/nprot.2007.405

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Subject classification obtained by cluster analysis and principal component analysis applied to flow cytometric data

Autor: Milena Nasi, Enrico Lugli, Marcello Pinti, Valeri Patsekin, Roberta Ferraresi, Caterina Durante, J. Paul Robinson, Chiara Mussi, Gianfranco Salvioli, Andrea Cossarizza, Leonarda Troiano, Marina Cocchi

Publikováno v: Cytometry Part A. :334-344

Background: Polychromatic flow cytometry (PFC) allows the simultaneous determination of multiple antigens in the same cell, resulting in the generation of a high number of subsets. As a consequence, data analysis is the main difficulty with this tech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4f4aa3548ce17fdacddf6c94408861
https://doi.org/10.1002/cyto.a.20387

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Thymic output and functionality of the IL-7/IL-7 receptor system in centenarians: implications for the neolymphogenesis at the limit of human life

Autor: Chiara Mussi, Roberta Ferraresi, Marcello Pinti, Milena Nasi, Enrico Lugli, Leonarda Troiano, Claudio Franceschi, Gianfranco Salvioli, Elena Monterastelli, Andrea Cossarizza

Publikováno v: Aging Cell. 5:167-175

During aging, the thymus undergoes a marked involution that is responsible for profound changes in the T-cell compartment. To investigate the capacity of the thymus to produce new cells at the limit of human lifespan, we analyzed some basic mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a97468a39c2bbfeacf66747fbf4880c
https://doi.org/10.1111/j.1474-9726.2006.00204.x

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Effect of treatment interruption monitored by CD4 cell count on mitochondrial DNA content in HIV-infected patients: a prospective study

Autor: Andrea Cossarizza, Andrea Bedini, Elisa Nemes, Leonarda Troiano, Roberto Esposito, Vanni Borghi, Roberto Bugarini, Milena Nasi, Cristina Mussini, Giovanni Guaraldi, Caroline A. Sabin, Marcello Pinti

Publikováno v: Scopus-Elsevier

Background: HIV infection per se and HAART can alter mitochondrial functionality, leading to a decrease in mitochondrial DNA content.Objective: To evaluate whether treatment interruption monitored by CD4 cell count can restore mitochondrial DNA conte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f39244dc6329ddac494c270792037db
https://doi.org/10.1097/01.aids.0000186019.47297.0d

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Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naïve HIV-positive patients

Autor: Cristian Bellodi, Roberto Bugarini, Milena Nasi, Fiorella Balli, Andrea Cossarizza, Leonarda Troiano, Enrico Lugli, Roberto Esposito, Cristina Mussini, Tommaso Trenti, Marcello Pinti, Vanni Borghi

Publikováno v: Immunogenetics. 57:628-635

Fas and Fas ligand (FasL) are the main genes that control cell death in the immune system. Indeed, they are crucial for the regulation of T lymphocyte homeostasis because they can influence cell proliferation. A strong debate exists on the importance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e878b9ed5ba7dcdcdae7268929e66c
https://doi.org/10.1007/s00251-005-0031-z

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