Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Leonard da Silva"'
Autor:
Jamie R. Kutasovic, Amy E. McCart Reed, Anna Sokolova, Janani Jayanthan, Leonard Da Silva, Peter T. Simpson, Sunil R. Lakhani
Publikováno v:
Clinical Case Reports, Vol 8, Iss 12, Pp 2725-2731 (2020)
Abstract Breast cancer metastasis to the stomach is rare; invasive lobular carcinoma has a predilection to spread to the gastrointestinal system and is morphologically similar to primary diffuse gastric carcinoma. This case highlights heterogeneous m
Externí odkaz:
https://doaj.org/article/89eb88014fb64d90b731212f61b5caac
Autor:
Chanel E Smart, Marjan E Askarian Amiri, Ania Wronski, Marcel E Dinger, Joanna Crawford, Dmitry A Ovchinnikov, Ana Cristina Vargas, Lynne Reid, Peter T Simpson, Sarah Song, Christiane Wiesner, Juliet D French, Richa K Dave, Leonard da Silva, Amy Purdon, Megan Andrew, John S Mattick, Sunil R Lakhani, Melissa A Brown, Stuart Kellie
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40742 (2012)
The protein tyrosine phosphatase receptor J, PTPRJ, is a tumor suppressor gene that has been implicated in a range of cancers, including breast cancer, yet little is known about its role in normal breast physiology or in mammary gland tumorigenesis.
Externí odkaz:
https://doaj.org/article/d5eaa5f72a81446caa82d85295dc8909
Autor:
George DeMuth, Sarat Chandarlapaty, Belma Dogdas, Patricia Raciti, Victor E. Reuter, Julian Viret, Carlos Gil Ferreira, Rodrigo Ceballos, Bruno L. Ferrari, Ran Godrich, Jeremy D. Kunz, Jorge S. Reis-Filho, Leo Grady, Paulo G O Salles, Adam Casson, Leonard Da Silva, Emílio M. Pereira, Jillian Sue, Christopher Kanan, Brandon Rothrock, Thomas J. Fuchs
Publikováno v:
The Journal of Pathology
Artificial intelligence (AI)‐based systems applied to histopathology whole‐slide images have the potential to improve patient care through mitigation of challenges posed by diagnostic variability, histopathology caseload, and shortage of patholog
Autor:
Peter T. Simpson, Sunil R. Lakhani, Anna Sokolova, Jamie R. Kutasovic, Leonard Da Silva, Amy E. McCart Reed, Janani Jayanthan
Publikováno v:
Clinical Case Reports
Clinical Case Reports, Vol 8, Iss 12, Pp 2725-2731 (2020)
Clinical Case Reports, Vol 8, Iss 12, Pp 2725-2731 (2020)
Breast cancer metastasis to the stomach is rare; invasive lobular carcinoma has a predilection to spread to the gastrointestinal system and is morphologically similar to primary diffuse gastric carcinoma. This case highlights heterogeneous metastatic
Autor:
Scott M. Weissman, Martha Quezado, Katia Nones, Manuel A. R. Ferreira, Florian Grimpen, Sue Healey, Kelly Hamman, Samantha Hansford, Kasmintan A. Schrader, Anne Marie Patch, Itzhak Avital, Daniel L. Worthley, Pardeep Kaurah, Robertson MacKenzie, Juliet D. French, Evangelos Bellos, Jun Li, Kevin P. Rioux, George Chong, Georgia Chenevix-Trench, Leonard Da Silva, Kathleen A. Calzone, Graeme Suthers, Deborah W. Neklason, Andrew D. Clouston, Hilary C. Martin, Paul S. Meltzer, Jone E. Sampson, Kerry Phillips, Oliver F. Bathe, Theo Heller, Nicola K. Poplawski, Stacey L. Edwards, Peter T. Simpson, Alireza Heravi-Moussavi, David G. Huntsman, Janine Senz, Mark Bettington, Jonathan Beesley, Nicci Wayte, Tamsin R M Lannagan, Xiaoqing Chen, Wendy S. Rubinstein, Lyn Schofield, David E. Goldgar, Christopher Koh, Noralane M. Lindor, Lachlan J. M. Coin, Marie Jeanjean, Joshua J. Waterfall, Pavel N. Pichurin, Amanda B. Spurdle, Sylviane Olschwang, John V. Pearson, Udo Rudloff, Fátima Carneiro, Nicola Waddell, Sunil R. Lakhani, Rita A. Busuttil, Susan L. Woods, Anna Newlin, Haran Sivakumaran, Natasha Di Costanzo, Aurélie Fabre, Xiaogang Wen, Geoffrey J. Faulkner, Jason Sang Hun Lee, Robert L. Walker, Cathy Kiraly-Borri, Peter J. Hulick, Marbin Pineda, Sean Davis, Alex Boussioutas, William D. Foulkes, Jacqueline Armstrong
Publikováno v:
American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 2016, 98 (5), pp.830-842. ⟨10.1016/j.ajhg.2016.03.001⟩
American Journal of Human Genetics, 2016, 98 (5), pp.830-842. ⟨10.1016/j.ajhg.2016.03.001⟩
American Journal of Human Genetics, Elsevier (Cell Press), 2016, 98 (5), pp.830-842. ⟨10.1016/j.ajhg.2016.03.001⟩
American Journal of Human Genetics, 2016, 98 (5), pp.830-842. ⟨10.1016/j.ajhg.2016.03.001⟩
International audience; Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is an autosomal-dominant cancer-predisposition syndrome with a significant risk of gastric, but not colorectal, adenocarcinoma. We mapped the gene to 5q22 an
Autor:
Sunil R. Lakhani, Amy E. McCart Reed, Elizabeth Evans, Ana Cristina Vargas, Amel Al‐Murrani, Jamie R. Kutasovic, Janani Jayanthan, Lynne Reid, Rachael Chambers, Leonard Da Silva, Peter T. Simpson, Alan Porter, Erik W. Thompson, David Papadimos, Lewis Melville
Publikováno v:
The Journal of Pathology. 238:489-494
Epithelial to mesenchymal transition (EMT) is a cellular phenotype switching phenomenon which occurs during normal development and is proposed to promote tumour cell invasive capabilities during tumour progression. Invasive lobular carcinoma (ILC) is
Autor:
Jorge S. Reis-Filho, Paulo G O Salles, Leo Grady, Sarat Chandarlapaty, Leonard Da Silva, Christopher Kanan, Emílio M. Pereira, Jillian Sue, Carlos Gil Ferreira, Thomas J. Fuchs
Publikováno v:
Journal of Clinical Oncology. 38:e14076-e14076
e14076 Background: The most common approach to diagnose prostate cancer is the “whole gland biopsy procedure,” in which numerous cores (≥12) are taken from different regions of the gland to maximize the chances of detecting small cancers; the p
Autor:
Mythily Mariasegaram, Ann-Marie Patch, Conrad Leonard, Admire Matsika, Sean M. Grimmond, Fares Al-Ejeh, Margaret C. Cummings, Rosalind L. Jeffree, Georgia Chenevix-Trench, Oliver Holmes, Leonard Da Silva, Nur Aishah Taib, Adrienne M. Flanagan, Teresa K. Withers, Matthew J. Anderson, Vairavan Narayanan, Ehsan Nourbakhsh, Queenie Lau, Sunil R. Lakhani, J. Lynn Fink, kConFab, Felicity Newell, Katia Nones, Stephen H. Kazakoff, Colleen Niland, Parmjit S. Jat, Ivon Harliwong, Peter T. Simpson, Lynne Reid, Nicola Waddell, Soo Hwang Teo, Karin S. Kassahn, Sebastian Brandner, John V. Pearson, Nick Waddell, Qinying Xu, Scott Wood, Darrin Taylor, Senel Idrisoglu, Peter Wilson, Timothy J. C. Bruxner, Kum Kum Khanna, Craig Nourse, Shivangi Wani, Angelika N. Christ, David Miller, Amy E. McCart Reed, Michael C.J. Quinn, Yock Ping Chow, Jodi M. Saunus, Suzanne Manning, Peter Bailey
Publikováno v:
The Journal of Pathology. 237:363-378
Treatment options for patients with brain metastases (BMs) have limited efficacy and the mortality rate is virtually 100%. Targeted therapy is critically under-utilized, and our understanding of mechanisms underpinning metastatic outgrowth in the bra
Autor:
Amy E, McCart Reed, Jamie R, Kutasovic, Katia, Nones, Jodi M, Saunus, Leonard, Da Silva, Felicity, Newell, Stephen, Kazakoff, Lewis, Melville, Janani, Jayanthan, Ana Cristina, Vargas, Lynne E, Reid, Jonathan, Beesley, Xiao Qing, Chen, Anne-Marie, Patch, David, Clouston, Alan, Porter, Elizabeth, Evans, John V, Pearson, Georgia, Chenevix-Trench, Margaret C, Cummings, Nicola, Waddell, Sunil R, Lakhani, Peter T, Simpson
Publikováno v:
The Journal of Pathology
Mixed ductal–lobular carcinomas (MDLs) show both ductal and lobular morphology, and constitute an archetypal example of intratumoural morphological heterogeneity. The mechanisms underlying the coexistence of these different morphological entities a
Autor:
Emma Bolderson, Julia J. Gorski, Fares Al-Ejeh, Nicole Chee, Sunil R. Lakhani, Peter T. Simpson, Kum Kum Khanna, Georgia Chenevix-Trench, Leonard Da Silva, Adrian P. Wiegmans, Pei-Yi Yap, Robin L. Anderson
Publikováno v:
Oncotarget
ResearcherID
Wiegmans, A P, Al-Ejeh, F, Chee, N, Yap, P Y, Gorski, J J, Da Silva, L, Bolderson, E, Chenevix-Trench, G, Anderson, R, Simpson, P T, Lakhani, S R & Khanna, K K 2014, ' Rad51 supports triple negative breast cancer metastasis ', Oncotarget, vol. 5, no. 10, pp. 3261-3272 . https://doi.org/10.18632/oncotarget.1923
ResearcherID
Wiegmans, A P, Al-Ejeh, F, Chee, N, Yap, P Y, Gorski, J J, Da Silva, L, Bolderson, E, Chenevix-Trench, G, Anderson, R, Simpson, P T, Lakhani, S R & Khanna, K K 2014, ' Rad51 supports triple negative breast cancer metastasis ', Oncotarget, vol. 5, no. 10, pp. 3261-3272 . https://doi.org/10.18632/oncotarget.1923
In contrast to extensive studies on familial breast cancer, it is currently unclear whether defects in DNA double strand break (DSB) repair genes play a role in sporadic breast cancer development and progression. We performed analysis of immunohistoc