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pro vyhledávání: '"Leonard Wu"'
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-5 (2024)
Abstract Background CHANTER (Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion) is a recently described syndrome occurring in the context of drug abuse. While clinical findings are rather unspecific (disorientation, un
Externí odkaz:
https://doaj.org/article/9a23b81d70044f98a6e3cf372d3426f1
Autor:
Marie Schäbitz, Leona Möller, Anja Friedrich, Nele Klein, Alkisti Kitsiou, Isabell Greeve, Anja Gerstner, Leonard Wulff, Wolf-Rüdiger Schäbitz, Lars Timmermann, Andreas Rogalewski
Publikováno v:
Neurological Research and Practice, Vol 5, Iss 1, Pp 1-16 (2023)
Abstract Background Evaluation of outcome after stroke is largely based on assessment of gross function 3 months after stroke onset using scales such as mRS. Cognitive or social functions, level of symptom burden or emotional health are not usually a
Externí odkaz:
https://doaj.org/article/d68f0a6dff5441329327d21aa5f8e35c
Publikováno v:
Nucleic Acids Research
The product of the gene mutated in Bloom's syndrome, BLM, is a 3'-5' DNA helicase belonging to the highly conserved RecQ family. In addition to a conventional DNA strand separation activity, BLM catalyzes both the disruption of non-B-form DNA, such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846466d932147f77a70204424b2a5ade
http://doc.rero.ch/record/292921/files/gki712.pdf
http://doc.rero.ch/record/292921/files/gki712.pdf
Publikováno v:
Clinical, Cosmetic and Investigational Dermatology
Background Pyoderma gangrenosum (PG) is a rare dermatological condition characterized by the rapid progression of a painful, necrolytic ulcer with an irregular, undermined border and commonly affects the lower extremities, mainly in the pretibial are
Publikováno v:
The Journal of Biological Chemistry
HEL308 is a superfamily II DNA helicase, conserved from archaea through to humans. HEL308 family members were originally isolated by their similarity to the Drosophila melanogaster Mus308 protein, which contributes to the repair of replication-blocki
Autor:
Ye Dee Tay, Leonard Wu
Publikováno v:
Journal of Biological Chemistry. 285:11427-11432
Eukaryotic Holliday junction (HJ) resolvases have attracted much attention recently with the identification of at least three distinct proteins that can cleave model HJs in vitro. However, the specific DNA structure(s) that these proteins act upon in
Publikováno v:
Proceedings of the National Academy of Sciences. 105:16107-16112
Fanconi anemia (FA) is a genetically heterogeneous chromosome instability syndrome associated with congenital abnormalities, bone marrow failure, and cancer predisposition. Eight FA proteins form a nuclear core complex, which promotes tolerance of DN
Autor:
Leonard Wu
Publikováno v:
DNA Repair. 6:936-944
Genomic DNA is particularly vulnerable to mutation during S-phase when the two strands of parental duplex DNA are separated during the process of semi-conservative DNA replication. Lesions that are normally repaired efficiently in the context of doub
Autor:
Ian D. Hickson, Leonard Wu
Publikováno v:
Annual Review of Genetics. 40:279-306
DNA helicases are found in all kingdoms of life and function in all DNA metabolic processes where the two strands of duplex DNA require to be separated. Here, we review recent developments in our understanding of the roles that helicases play in the
Autor:
Chang Xu, Csanád Z. Bachrati, Leonard Wu, Michael Chang, Jiongwen Ou, Ian D. Hickson, Lei Li, Grant W. Brown, Weidong Wang, Jinhu Yin
Publikováno v:
Proceedings of the National Academy of Sciences. 103:4068-4073
BLM encodes a member of the highly conserved RecQ DNA helicase family, which is essential for the maintenance of genome stability. Homozygous inactivation of BLM gives rise to the cancer predisposition disorder Bloom’s syndrome. A common feature of