Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leonard Schalkwyk"'
Autor:
Yanchun Bao, Tyler Gorrie-Stone, Eilis Hannon, Amanda Hughes, Alexandria Andrayas, Grant Neilson, Joe Burrage, Jonathon Mill, Leonard Schalkwyk, Meena Kumari
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Disadvantaged socio-economic position (SEP) is associated with greater biological age, relative to chronological age, measured by DNA methylation (positive ‘age acceleration’, AA). Social mobility has been proposed to ameliorate health i
Externí odkaz:
https://doaj.org/article/03710914b56c4bc7a1d676ae8395efa3
Autor:
Matthew Devall, Darren M. Soanes, Adam R. Smith, Emma L. Dempster, Rebecca G. Smith, Joe Burrage, Artemis Iatrou, Eilis Hannon, Claire Troakes, Karen Moore, Paul O’Neill, Safa Al-Sarraj, Leonard Schalkwyk, Jonathan Mill, Michael Weedon, Katie Lunnon
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
BackgroundThere is growing interest in the role of DNA methylation in regulating the transcription of mitochondrial genes, particularly in brain disorders characterized by mitochondrial dysfunction. Here, we present a novel approach to interrogate th
Externí odkaz:
https://doaj.org/article/76c6f9056010427380458856bb8a4059
Autor:
Rebecca G. Smith, Ehsan Pishva, Gemma Shireby, Adam R. Smith, Janou A. Y. Roubroeks, Eilis Hannon, Gregory Wheildon, Diego Mastroeni, Gilles Gasparoni, Matthias Riemenschneider, Armin Giese, Andrew J. Sharp, Leonard Schalkwyk, Vahram Haroutunian, Wolfgang Viechtbauer, Daniel L. A. van den Hove, Michael Weedon, Danielle Brokaw, Paul T. Francis, Alan J. Thomas, Seth Love, Kevin Morgan, Jörn Walter, Paul D. Coleman, David A. Bennett, Philip L. De Jager, Jonathan Mill, Katie Lunnon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Although epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, previous studies have been limited in sample size and brain region used. Here, the authors combine data from
Externí odkaz:
https://doaj.org/article/dd2f5bd2ef1b4cbabe97720ed844e0d6
Autor:
Szi Kay Leung, Aaron R. Jeffries, Isabel Castanho, Ben T. Jordan, Karen Moore, Jonathan P. Davies, Emma L. Dempster, Nicholas J. Bray, Paul O’Neill, Elizabeth Tseng, Zeshan Ahmed, David A. Collier, Erin D. Jeffery, Shyam Prabhakar, Leonard Schalkwyk, Connor Jops, Michael J. Gandal, Gloria M. Sheynkman, Eilis Hannon, Jonathan Mill
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110022- (2021)
Summary: Alternative splicing is a post-transcriptional regulatory mechanism producing distinct mRNA molecules from a single pre-mRNA with a prominent role in the development and function of the central nervous system. We used long-read isoform seque
Externí odkaz:
https://doaj.org/article/1417caefb134428cac84fed4a4f86a78
Autor:
Matthew Devall, Rebecca G. Smith, Aaron Jeffries, Eilis Hannon, Matthew N. Davies, Leonard Schalkwyk, Jonathan Mill, Michael Weedon, Katie Lunnon
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-15 (2017)
Abstract Background DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases. Mitochondrial DNA methylation is a phenomenon t
Externí odkaz:
https://doaj.org/article/945ea65b766b4c2fbd4624efbe9dede7
Autor:
Nicholas E Ilott, Tomasz Schneider, Jonathan Mill, Leonard Schalkwyk, Giovana Brolese, Lisiane Bizarro, Ian P Stolerman, Emma Dempster, Philip Asherson
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88896 (2014)
Gestational exposure to environmental toxins such as nicotine may result in detectable gene expression changes in later life. To investigate the direct toxic effects of prenatal nicotine exposure on later brain development, we have used transcriptomi
Externí odkaz:
https://doaj.org/article/6adee7273bc34f2f94484d0d4d13452f
BackgroundDNA methylation (DNAm) based age clocks have been studied extensively as a biomarker of human ageing and risk factor for age-related diseases. Despite different tissues having vastly different rates of proliferation, it is still largely unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::315ff5e04775785514e84a299651a042
https://doi.org/10.1101/2022.05.16.492116
https://doi.org/10.1101/2022.05.16.492116
Publikováno v:
Clinical epigenetics. 14(1)
Background Sex differences are known to play a role in disease aetiology, progression and outcome. Previous studies have revealed autosomal epigenetic differences between males and females in some tissues, including differences in DNA methylation pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7b1f11374ccfdc4ae3865524bf114e
https://pubmed.ncbi.nlm.nih.gov/35568878
https://pubmed.ncbi.nlm.nih.gov/35568878
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.