Zobrazeno 1 - 10 of 186 pro vyhledávání: '"Leonard PM"'
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3
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[1,2,4]Triazolo[1,5- a ]pyrimidine Phosphodiesterase 2A Inhibitors: Structure and Free-Energy Perturbation-Guided Exploration.
Autor: Tresadern G; Computational Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Velter I; Medicinal Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Trabanco AA; Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S. A., Jarama 75A, 45007 Toledo, Spain., Van den Keybus F; Medicinal Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Macdonald GJ; Medicinal Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Somers MVF; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Vanhoof G; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Leonard PM; Structural Biology, Charles River Discovery (Previously BioFocus), Chesterford Research Park, Saffron Walden, CB10 1XL Essex, U.K., Lamers MBAC; Structural Biology, Charles River Discovery (Previously BioFocus), Chesterford Research Park, Saffron Walden, CB10 1XL Essex, U.K., Van Roosbroeck YEM; Medicinal Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Buijnsters PJJA; Medicinal Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12887-12910. Date of Electronic Publication: 2020 Oct 26.
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4
Akademický článek
Human case of bubonic plague resulting from the bite of a wild Gunnison's prairie dog during translocation from a plague-endemic area.
Autor: Melman SD; Epidemiology and Response Division, New Mexico Department of Health, Santa Fe, NM, USA., Ettestad PE; Epidemiology and Response Division, New Mexico Department of Health, Santa Fe, NM, USA., VinHatton ES; Epidemiology and Response Division, New Mexico Department of Health, Santa Fe, NM, USA., Ragsdale JM; New Mexico Department of Agriculture, Veterinary Diagnostic Services, Albuquerque, NM, USA., Takacs N; New Mexico Department of Agriculture, Veterinary Diagnostic Services, Albuquerque, NM, USA., Onischuk LM; Scientific Laboratory Division, New Mexico Department of Health, Albuquerque, NM, USA., Leonard PM; Scientific Laboratory Division, New Mexico Department of Health, Albuquerque, NM, USA., Master SS; Scientific Laboratory Division, New Mexico Department of Health, Albuquerque, NM, USA., Lucero VS; City of Santa Fe, Santa Fe, NM, USA., Kingry LC; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA., Petersen JM; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Publikováno v: Zoonoses and public health [Zoonoses Public Health] 2018 Feb; Vol. 65 (1), pp. e254-e258. Date of Electronic Publication: 2017 Nov 06.
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5
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6
Akademický článek
Identification and Investigation of Novel Binding Fragments in the Fatty Acid Binding Protein 6 (FABP6).
Autor: Hendrick AG; Takeda Cambridge , 418 Cambridge Science Park, Cambridge CB4 0PZ, United Kingdom., Müller I; Charles River , Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Willems H; Takeda Cambridge , 418 Cambridge Science Park, Cambridge CB4 0PZ, United Kingdom., Leonard PM; Charles River , Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Irving S; Charles River , Ingram Building, Parkwood Road, Canterbury, Kent CT2 7NH, United Kingdom., Davenport R; Takeda Cambridge , 418 Cambridge Science Park, Cambridge CB4 0PZ, United Kingdom., Ito T; Biomolecular Research Laboratories, Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome, Fujisawa 251-8555, Japan., Reeves J; Takeda Cambridge , 418 Cambridge Science Park, Cambridge CB4 0PZ, United Kingdom., Wright S; Takeda Cambridge , 418 Cambridge Science Park, Cambridge CB4 0PZ, United Kingdom., Allen V; Charles River , Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Wilkinson S; Charles River , Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Heffron H; Takeda Cambridge , 418 Cambridge Science Park, Cambridge CB4 0PZ, United Kingdom., Bazin R; Charles River , Ingram Building, Parkwood Road, Canterbury, Kent CT2 7NH, United Kingdom., Turney J; Charles River , Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Mitchell PJ; Takeda Cambridge , 418 Cambridge Science Park, Cambridge CB4 0PZ, United Kingdom.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Sep 08; Vol. 59 (17), pp. 8094-102. Date of Electronic Publication: 2016 Aug 18.
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7
Akademický článek
Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).
Autor: Osborne JD, Matthews TP, McHardy T, Proisy N, Cheung KM, Lainchbury M, Brown N, Walton MI, Eve PD, Boxall KJ, Hayes A, Henley AT, Valenti MR, De Haven Brandon AK, Box G, Jamin Y, Robinson SP, Westwood IM, van Montfort RL, Leonard PM; Sareum Ltd. , Cambridge CB22 3FX, U.K., Lamers MB; Sareum Ltd. , Cambridge CB22 3FX, U.K., Reader JC; Sareum Ltd. , Cambridge CB22 3FX, U.K., Aherne GW, Raynaud FI, Eccles SA, Garrett MD, Collins I
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Jun 09; Vol. 59 (11), pp. 5221-37. Date of Electronic Publication: 2016 May 23.
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8
Akademický článek
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.
Autor: Luckhurst CA; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Breccia P; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Stott AJ; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Aziz O; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Birch HL; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Bürli RW; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Hughes SJ; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Jarvis RE; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Lamers M; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Leonard PM; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Matthews KL; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., McAllister G; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Pollack S; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Saville-Stones E; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Wishart G; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Yates D; BioFocus, Charles River , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Dominguez C; CHDI Management/CHDI Foundation Inc. , 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Dec 10; Vol. 7 (1), pp. 34-9. Date of Electronic Publication: 2015 Dec 10 (Print Publication: 2016).
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9
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