Cancer suppression and the evolution of multiple retrogene copies of TP53 in elephants: A re‐evaluation

Autor: Leonard Nunney

Publikováno v: Evolutionary Applications, Vol 15, Iss 5, Pp 891-901 (2022)

Abstract Evolving to become bigger and/or longer lived should increase cancer susceptibility, but this predicted increase is not observed, a contradiction named Peto's paradox. A solution is that cancer suppression evolves to minimize cancer suscepti

Externí odkaz: https://doaj.org/article/4924bcd7e9a3450494240fbb3db2a5ac

Resolving Peto’s paradox: Modeling the potential effects of size‐related metabolic changes, and of the evolution of immune policing and cancer suppression

Autor: Leonard Nunney

Publikováno v: Evolutionary Applications, Vol 13, Iss 7, Pp 1581-1592 (2020)

Abstract The intrinsic risk of cancer increases with body size and longevity; however, big long‐lived species do not exhibit this increase, a contradiction named Peto's paradox. Five hypotheses potentially resolving this paradox were modeled using

Externí odkaz: https://doaj.org/article/1120d92d746a4e5a9cd4bb57a1b49897

The complex biogeography of the plant pathogen Xylella fastidiosa: genetic evidence of introductions and Subspecific introgression in Central America.

Autor: Leonard Nunney, Beatriz Ortiz, Stephanie A Russell, Rebeca Ruiz Sánchez, Richard Stouthamer

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e112463 (2014)

The bacterium Xylella fastidiosa is a plant pathogen with a history of economically damaging introductions of subspecies to regions where its other subspecies are native. Genetic evidence is presented demonstrating the introduction of two new taxa in

Externí odkaz: https://doaj.org/article/b0a9d940189e402184f54c45883677b5

Telomeres, the loop tying cancer to organismal life‐histories

Autor: Beata Ujvari, Nynke Raven, Thomas Madsen, Marcel Klaassen, Antoine M. Dujon, Aaron G. Schultz, Leonard Nunney, Jean‐François Lemaître, Mathieu Giraudeau, Frédéric Thomas

Publikováno v: Molecular Ecology
Molecular Ecology, 2022, 31 (23), pp.6273-6285. ⟨10.1111/mec.16488⟩

International audience; Recent developments in telomere and cancer evolutionary ecology demonstrate a very complex relationship between the need of tissue repair and controlling the emergence of abnormally proliferating cells. The trade-off is balanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18ff3a356f65fc7c4a6238ee4677039
https://doi.org/10.1111/mec.16488

Identifying key questions in the ecology and evolution of cancer

Autor: Holly A. Swain Ewald, Michael J. Metzger, Susanne Sebens, Irina Kareva, Joel S. Brown, Mathieu Giraudeau, Carlo C. Maley, Jean Pascal Capp, Pascal Pujol, Amy M. Boddy, Benjamin Roche, Robert Noble, Kornelia Polyak, Leonard Nunney, Beata Ujvari, Eric Solary, Frédéric Thomas, Rodrigo Hamede, Antoine M. Dujon, Kateřina Staňková, Andriy Marusyk, Aurora M. Nedelcu, Nicholas McGranahan, Marco Gerlinger, Paul W. Ewald, Robert A. Gatenby, James DeGregori, Sarah R. Amend, Andrew F. Read, Elsa Hansen, Kenneth J. Pienta, Catherine Alix-Panabières, Athena Aktipis

Publikováno v: Evolutionary applications, vol 14, iss 4
Evolutionary Applications
Evolutionary Applications, Blackwell, 2021, ⟨10.1111/eva.13190⟩
Evolutionary Applications, 14(4), 877-892. Wiley-Blackwell
Evolutionary Applications, 14(4)
Evolutionary Applications, Vol 14, Iss 4, Pp 877-892 (2021)
Evolutionary Applications, 2021, ⟨10.1111/eva.13190⟩
Evolutionary Applications, 14 (4)

Early Access; International audience; The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years. Following the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b31b1c2ff5741c43694f144eb20ca9
https://escholarship.org/uc/item/9p20m3jd