Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Leonard M. Hjelmeland"'
Autor:
Zeljka Smit-McBride, Elad Moisseiev, Sara P. Modjtahedi, David G. Telander, Leonard M. Hjelmeland, Lawrence S. Morse
Publikováno v:
Journal of Ophthalmology, Vol 2016 (2016)
Purpose. To identify retinal pigment epithelium (RPE)/choroid genes and their relevant expression pathways affected by intravitreal injections of dexamethasone and triamcinolone acetonide in mice at clinically relevant time points for patient care. M
Externí odkaz:
https://doaj.org/article/5c04b8316d084ae6844f1a35208b8381
Autor:
Leonard M. Hjelmeland, Lawrence S Morse, Zeljka Smit-McBride, David G. Telander, Sara P. Modjtahedi, Elad Moisseiev
Publikováno v:
Journal of Ophthalmology, Vol 2016 (2016)
Journal of Ophthalmology
Journal of Ophthalmology
Purpose. To identify retinal pigment epithelium (RPE)/choroid genes and their relevant expression pathways affected by intravitreal injections of dexamethasone and triamcinolone acetonide in mice at clinically relevant time points for patient care.Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046f951b2a60fb617eaa4d71971dec24
https://doaj.org/article/5c04b8316d084ae6844f1a35208b8381
https://doaj.org/article/5c04b8316d084ae6844f1a35208b8381
Publikováno v:
International Journal of Quantum Chemistry. 12:225-244
Ab initio and semiempirical molecular orbital calculations are made for a heme-containing model of the biologically active state of cytochrome P-450 and for two chemical models of the enzyme, chromyl chloride (CrO2Cl2) and peroxytrifluoroacetic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::affbe5194d578abd182e441c57ffc875
https://doi.org/10.1002/qua.560120724
https://doi.org/10.1002/qua.560120724
Autor:
Rachel Anderson, Susanna S Park, David G. Telander, Esther Kim, Lawrence S Morse, Zeljka Smit-McBride, Gui-Shuang Ying, Joshua L. Dunaief, Matthew H. Bordbari, Leonard M. Hjelmeland, Allan A. Hunter
Publikováno v:
Current eye research. 41(3)
Previously, two cytosolic antioxidant enzymes, Glutathione S-transferase Mu 1 (GSTM1) and Mu 5 (GSTM5), were reduced in retinas with age-related macular degeneration (AMD). This study compared genomic copy number variations (gCNV) of these two antiox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86456d4d586aed9f9f835a4cbd1f8e4a
https://pubmed.ncbi.nlm.nih.gov/25897651
https://pubmed.ncbi.nlm.nih.gov/25897651
Publikováno v:
Experimental Eye Research. 83:679-687
Cystatin C is the major inhibitor of the cysteine cathepsins. Polymorphisms in the cystatin C gene have recently been associated with the risk of developing Age-related Macular Degeneration (AMD). Oxidative stress is also thought to play a key role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9240501bbd5e598ffc3d0fc22b794732
https://doi.org/10.1016/j.exer.2006.03.009
https://doi.org/10.1016/j.exer.2006.03.009
Autor:
Kazuki Ishibashi, S A Boylan, Shigeru Honda, Jing Tian, James T. Handa, Leonard M. Hjelmeland
Publikováno v:
British Journal of Ophthalmology. 89:1510-1517
Aim: To determine the transcriptional proximity of retinal pigment epithelium (RPE) cells grown under different culture conditions and native RPE. Methods: ARPE-19 cells were grown under five conditions in 10% CO2: “subconfluent” in DMEM/F12 + 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0184f12571c9dc12b12bf052b383b47
https://doi.org/10.1136/bjo.2005.072108
https://doi.org/10.1136/bjo.2005.072108
Autor:
Janice M. Burke, Leonard M. Hjelmeland
Publikováno v:
Molecular Interventions. 5:241-249
The retinal pigment epithelium (RPE) is a monolayer of cells that appear phenotypically regular, but which exhibit striking cell-cell variability in content of melanin and lipofuscin granules, and in expression of many proteins. This naturally occurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa6530b07d0bb8adab729410a1ea586
https://doi.org/10.1124/mi.5.4.7
https://doi.org/10.1124/mi.5.4.7
Autor:
Lawrence S Morse, S A Boylan, Noritake Miyamura, Leonard M. Hjelmeland, James T. Handa, Tsukihiko Ogawa
Publikováno v:
Investigative Ophthalmology & Visual Science. 45:1562-1565
PURPOSE. To investigate the hypothesis that there are topographic and age-related changes in the expression of heme oxygenase (HO)-1 and catalase in the RPE. METHODS. Cryosections of the macula and periphery of human eyes (n = 18; aged 27-87 years) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da618b48c673e2b3f20585f072d984ab
https://doi.org/10.1167/iovs.02-0761
https://doi.org/10.1167/iovs.02-0761
Publikováno v:
Free Radical Biology and Medicine. 35:465-474
Oxidative stress has been studied in the retinal pigmented epithelium (RPE) in vitro but not in vivo. Our purpose, therefore, was to develop an in vivo model of acute oxidative stress in the C57BL/6J mouse. Mice were exposed toor = 98% oxygen for 0,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c82dd206a26fce5411e20c889de1269
https://doi.org/10.1016/s0891-5849(03)00320-4
https://doi.org/10.1016/s0891-5849(03)00320-4
Publikováno v:
Free Radical Biology and Medicine. 33:1419-1432
Oxidative stress plays a key role in aging diseases of the posterior pole of the eye such as age-related macular degeneration. The oxidative stress response of in vitro RPE cells has been studied for a small number of genes. However, a comprehensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c787669dc1f28b93ec319cfae27e0fd3
https://doi.org/10.1016/s0891-5849(02)01082-1
https://doi.org/10.1016/s0891-5849(02)01082-1