Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Leonard M Neckers"'
Autor:
Aseervatham Anusha Amali, Kathirvel Paramasivam, Chiung Hui Huang, Abhinav Joshi, Jayshree L. Hirpara, Sharada Ravikumar, Qi Hui Sam, Rachel Ying Min Tan, Zhaohong Tan, Dilip Kumar, Leonard M. Neckers, Shazib Pervaiz, Roger Foo, Candice Y Y Chan, Jin Zhu, Cheryl Lee, Louis Yi Ann Chai
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Molecular chaperons stabilize protein folding and play a vital role in maintaining tissue homeostasis. To this intent, mitochondrial molecular chaperons may be involved in the regulation of oxidative phosphorylation and apoptosis during stress events
Externí odkaz:
https://doaj.org/article/e1cb52a4b17842cf89640d2446bca83c
Autor:
Ting Zhang, Xinrui Yang, Wanping Xu, Jing Wang, Dawei Wu, Zhixian Hong, Shengxian Yuan, Zhen Zeng, Xiaodong Jia, Shanshan Lu, Rifaat Safadi, Sen Han, Zhihong Yang, Leonard M. Neckers, Suthat Liangpunsakul, Weiping Zhou, Yinying Lu
Publikováno v:
Cancer Biology & Medicine, Vol 18, Iss 3, Pp 693-704 (2021)
Objective: Hepatocellular carcinoma (HCC), the main type of liver cancer, has a high morbidity and mortality, and a poor prognosis. RNA helicase DDX5, which acts as a transcriptional co-regulator, is overexpressed in most malignant tumors and promote
Externí odkaz:
https://doaj.org/article/984ca1114e1647d6ba9af5a5f0dd2cc7
Autor:
Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1798-1810.e4 (2020)
Summary: The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to dete
Externí odkaz:
https://doaj.org/article/b3f7874afa484caba2d1087fcf914a16
Autor:
R. Taylor Ripley, David S. Schrump, Jonathan M. Hernandez, Chuong D. Hoang, Jeremy L. Davis, Leonard M. Neckers, Derek J. Nancarrow, David G. Beer, Laurence P. Diggs, Kaitlin C. McLoughlin, Sichuan Xi, Shaojian Gao, Min-Jung Lee, Sunmin Lee, Jane B. Trepel, Daniel R. Crooks, Emily S. Reardon, Vivek Shukla, Lucas A. McDuffie, Yuan Xu, Kate Brown, Deborah R. Surman, Paul L. Feingold
RNAse Esc2 TXNIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cb2352cf6ee8517ba836977219d285
https://doi.org/10.1158/1535-7163.22505272.v1
https://doi.org/10.1158/1535-7163.22505272.v1
Autor:
R. Taylor Ripley, David S. Schrump, Jonathan M. Hernandez, Chuong D. Hoang, Jeremy L. Davis, Leonard M. Neckers, Derek J. Nancarrow, David G. Beer, Laurence P. Diggs, Kaitlin C. McLoughlin, Sichuan Xi, Shaojian Gao, Min-Jung Lee, Sunmin Lee, Jane B. Trepel, Daniel R. Crooks, Emily S. Reardon, Vivek Shukla, Lucas A. McDuffie, Yuan Xu, Kate Brown, Deborah R. Surman, Paul L. Feingold
In 2017, an estimated 17,000 individuals were diagnosed with esophageal adenocarcinoma (EAC), and less than 20% will survive 5 years. Positron emission tomography avidity is indicative of high glucose utilization and is nearly universal in EAC. TXNIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e340b99ca40389ffa9f98c0fced22dc
https://doi.org/10.1158/1535-7163.c.6538015.v1
https://doi.org/10.1158/1535-7163.c.6538015.v1
Autor:
Xuemei Chen, Fei Zou, Leonard M. Neckers, Hongjun Yang, Wenchong Tan, Xueqiong Zhou, Manfeng Liang, Jieyou Li, Jinxin Zhang, Zihao Deng, Zhenming Zheng, Yaotang Deng, Lixia Liu
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e10aea1ea5ffe506c4681d6626592f5
https://doi.org/10.1158/1535-7163.22520707.v1
https://doi.org/10.1158/1535-7163.22520707.v1
Autor:
R. Taylor Ripley, David S. Schrump, Jonathan M. Hernandez, Chuong D. Hoang, Jeremy L. Davis, Leonard M. Neckers, Derek J. Nancarrow, David G. Beer, Laurence P. Diggs, Kaitlin C. McLoughlin, Sichuan Xi, Shaojian Gao, Min-Jung Lee, Sunmin Lee, Jane B. Trepel, Daniel R. Crooks, Emily S. Reardon, Vivek Shukla, Lucas A. McDuffie, Yuan Xu, Kate Brown, Deborah R. Surman, Paul L. Feingold
Cells and Reagents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bce5e7960c6cb1e98e4c8f87eeb3406
https://doi.org/10.1158/1535-7163.22505263
https://doi.org/10.1158/1535-7163.22505263
Autor:
R. Taylor Ripley, David S. Schrump, Jonathan M. Hernandez, Chuong D. Hoang, Jeremy L. Davis, Leonard M. Neckers, Derek J. Nancarrow, David G. Beer, Laurence P. Diggs, Kaitlin C. McLoughlin, Sichuan Xi, Shaojian Gao, Min-Jung Lee, Sunmin Lee, Jane B. Trepel, Daniel R. Crooks, Emily S. Reardon, Vivek Shukla, Lucas A. McDuffie, Yuan Xu, Kate Brown, Deborah R. Surman, Paul L. Feingold
Supplemental Figure 1: Chromatin immunoprecipitation was performed to assess the histone modification marks, H3K27Me3, H3K9Ac2, H3K4Me3, and H3K79Me2 in Flo-1 and Esc2 after glutamine withdrawal; Supplemental Figure 2: qRT-PCR normalized to b-actin m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddae6a9e59936bf7cb288418158c173
https://doi.org/10.1158/1535-7163.22505275
https://doi.org/10.1158/1535-7163.22505275
Autor:
Xuemei Chen, Fei Zou, Leonard M. Neckers, Hongjun Yang, Wenchong Tan, Xueqiong Zhou, Manfeng Liang, Jieyou Li, Jinxin Zhang, Zihao Deng, Zhenming Zheng, Yaotang Deng, Lixia Liu
Supplemental Figures 1-7 Merged PDF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be0b1ef048ae94e54db854cd24103c2
https://doi.org/10.1158/1535-7163.22520701
https://doi.org/10.1158/1535-7163.22520701
Autor:
Frank J Echtenkamp, Ryo Ishida, Genesis M Rivera-Marquez, Marisa Maisiak, Oleta T Johnson, Jonathan H Shrimp, Arnav Sinha, Stephen John Ralph, Ian Nisbet, Murali Krishna Cherukuri, Jason E Gestwicki, Leonard M Neckers
Publikováno v:
PNAS Nexus
PNAS nexus, vol 2, iss 4
PNAS nexus, vol 2, iss 4
The androgen receptor is a key regulator of prostate cancer and the principal target of current prostate cancer therapies collectively termed androgen deprivation therapies. Insensitivity to these drugs is a hallmark of progression to a terminal dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c14ec7cbf7dcddfe214f2794fc2679b
https://europepmc.org/articles/PMC10118397/
https://europepmc.org/articles/PMC10118397/