Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Leonard Lipovich"'
Autor:
Deya Obaidat, Roberta Giordo, Erica L. Kleinbrink, Emilia Banisad, Lawrence I. Grossman, Rooshan Arshad, Azadeh Stark, Marie-Claire Maroun, Leonard Lipovich, Félix Fernandez-Madrid
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Autoantibodies against mitochondrial-derived antigens play a key role in chronic tissue inflammation in autoimmune disorders and cancers. Here, we identify autoreactive nuclear genomic DNA (nDNA)-encoded mitochondrial gene products (GAPDH, PKM2, GSTP
Externí odkaz:
https://doaj.org/article/1f0ec1c09c34455b8314376b6d0d211a
Autor:
Tatiana Pavlovna Shkurat, Manar Ammar, Olga Bocharova, Elena Teplyakova, Anzhela Aleksandrova, Ruba Ali, Leonard Lipovich
Publikováno v:
Non-Coding RNA, Vol 9, Iss 2, p 22 (2023)
Long non-coding RNAs (lncRNAs) play important roles in the maintenance of metabolic homeostasis. Recently, many studies have suggested that lncRNAs, such as Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) and Imprinted Maternally Expr
Externí odkaz:
https://doaj.org/article/824632a931424b1dbf5da023af1ec5b0
Autor:
Jian-Pu Zheng, Xiangqin He, Fang Liu, Shuping Yin, Shichao Wu, Maozhou Yang, Jiawei Zhao, Xiaohua Dai, Hong Jiang, Luyi Yu, Qin Yin, Donghong Ju, Claire Li, Leonard Lipovich, Youming Xie, Kezhong Zhang, Hui J. Li, Jiliang Zhou, Li Li
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Yin Yang 1 (YY1) regulates gene transcription in a variety of biological processes. In this study, we aim to determine the role of YY1 in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and in vitro. Here we show that v
Externí odkaz:
https://doaj.org/article/cc7f4842bb50449f8d66b93adfce802c
Publikováno v:
Non-Coding RNA, Vol 9, Iss 1, p 3 (2023)
The human brain has evolved to have extraordinary capabilities, enabling complex behaviors. The uniqueness of the human brain is increasingly posited to be due in part to the functions of primate-specific, including human-specific, long non-coding RN
Externí odkaz:
https://doaj.org/article/af5bac4ad59c4695a055eb78fd7f4a4c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The recent increases in cancer incidences have been linked to lifestyle changes that result in obesity and metabolic syndrome. It is now evident that these trends are associated with the profound changes that occur in the intestinal microbiome, produ
Externí odkaz:
https://doaj.org/article/a61631136e424cca84b87c8dfcadc643
Autor:
Erica L. Kleinbrink, Nardhy Gomez-Lopez, Donghong Ju, Bogdan Done, Anton-Scott Goustin, Adi L. Tarca, Roberto Romero, Leonard Lipovich
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
In the post-genomic era, our understanding of the molecular regulators of physiologic and pathologic processes in pregnancy is expanding at the whole-genome level. Longitudinal changes in the known protein-coding transcriptome during normal pregnancy
Externí odkaz:
https://doaj.org/article/0defabfcefd3498686dad1096cde59bf
Publikováno v:
Cancers, Vol 14, Iss 14, p 3313 (2022)
Numerous epidemiological studies place patients with T2D at a higher risk for cancer. Many risk factors, such as obesity, ageing, poor diet and low physical activity, are shared between T2D and cancer; however, the biological mechanisms linking the t
Externí odkaz:
https://doaj.org/article/03c5d14ae90f43ca8093f93f17ab18d0
Autor:
Alisa K. Manning, Anton Scott Goustin, Erica L. Kleinbrink, Pattaraporn Thepsuwan, Juan Cai, Donghong Ju, Aaron Leong, Miriam S. Udler, James Bentley Brown, Mark O. Goodarzi, Jerome I. Rotter, Robert Sladek, James B. Meigs, Leonard Lipovich
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
AimsCausal transcripts at genomic loci associated with type 2 diabetes (T2D) are mostly unknown. The chr8p23.1 variant rs4841132, associated with an insulin-resistant diabetes risk phenotype, lies in the second exon of a long non-coding RNA (lncRNA)
Externí odkaz:
https://doaj.org/article/9d4e263c3f284be6a793db9ae92b53aa
Autor:
Tanvir Alam, Leonard Lipovich
Publikováno v:
Non-Coding RNA, Vol 7, Iss 1, p 18 (2021)
Sense-antisense interactions of long and short RNAs in human cells are integral to post-transcriptional gene regulation, in particular that of mRNAs by microRNAs. Many viruses, including severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 (the
Externí odkaz:
https://doaj.org/article/9f0aa27922794e6aa768f2a020b59af7
Autor:
Mihnea P. Dragomir, Ganiraju C. Manyam, Leonie Florence Ott, Léa Berland, Erik Knutsen, Cristina Ivan, Leonard Lipovich, Bradley M. Broom, George A. Calin
Publikováno v:
Non-Coding RNA, Vol 6, Iss 4, p 41 (2020)
Non-coding RNAs (ncRNAs) are essential players in many cellular processes, from normal development to oncogenic transformation. Initially, ncRNAs were defined as transcripts that lacked an open reading frame (ORF). However, multiple lines of evidence
Externí odkaz:
https://doaj.org/article/2f3f0122c22a47daad067a1809263343