Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Leonard L. Jones"'
Autor:
Mariya Hristova, Marion Bohatschek, Andrea Koppius, Thomas Doetschman, Ilona Ormsby, Karl Bauer, Milan Makwana, Dietmute Bueringer, Gennadij Raivich, Heike Heuer, Leonard L. Jones, Dan Cuthill, Sönke Friedrichsen
Publikováno v:
The Journal of Neuroscience. 27:11201-11213
Transforming growth factor beta1 (TGFbeta1) is a pleiotropic cytokine with potent neurotrophic and immunosuppressive properties that is upregulated after injury, but also expressed in the normal nervous system. In the current study, we examined the r
Publikováno v:
Experimental Neurology. 191:344-360
Bone marrow stromal cells (MSCs) constitute a heterogeneous cell layer in the bone marrow, supporting the growth and differentiation of hematopoietic stem cells. Recently, it has been reported that MSCs harbor pluripotent stem cells capable of neural
Publikováno v:
The Journal of Neuroscience. 23:9276-9288
Increased expression of certain extracellular matrix (ECM) molecules after CNS injury is believed to restrict axonal regeneration. The chondroitin sulfate proteoglycans (CSPGs) are one such class of ECM molecules that inhibit neurite outgrowthin vitr
Publikováno v:
Experimental Neurology. 182:399-411
Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that are widely expressed throughout the developing and adult CNS. In vitro studies demonstrate their potential to restrict neurite outgrowth, and it is believed that
Autor:
Alexander Werner, Klaus Pfeffer, ZhiQiang Liu, Marion Bohatschek, Xing-Zu Zhu, Leonard L. Jones, Gennadij Raivich, Christian U.A. Kloss, Matthias Galiano
Publikováno v:
Journal of Neuroscience Research. 72:726-733
Studies using mouse axotomised facial motoneuron model show a strong and highly selective entry of CD3+ lymphocytes into the affected nucleus, with a maximum at Day 14, which coincides with the peak of neuronal cell death, microglial phagocytosis, an
Publikováno v:
The Journal of Neuroscience. 22:2792-2803
Several extracellular matrix (ECM) molecules have been identified as potent inhibitors of neurite outgrowthin vitroand are believed to limit axonal growth after CNS injury. Recent studies have shown that different members of the chondroitin sulfate p
Autor:
Roger Kalla, Andrea Koppius, Alexander Werner, ZhiQiang Liu, Leonard L. Jones, ShengLi Xu, Christian U.A. Kloss, Andreas Gschwendtner, Marion Bohatschek, Matthias Galiano, Horst Bluethmann, Gennadij Raivich
Publikováno v:
European Journal of Neuroscience. 14:327-341
Nerve injury triggers numerous changes in the injured neurons and surrounding non-neuronal cells. Of particular interest are molecular signals that play a role in the overall orchestration of this multifaceted cellular response. Here we investigated
Publikováno v:
The Journal of Physiology. 533:83-89
Injury to the adult mammalian spinal cord results in extensive axonal degeneration, variable amounts of neuronal loss, and often severe functional deficits. Restoration of controlled function depends on regeneration of these axons through an injury s
Autor:
Alexander Werner, Leonard L. Jones, Gennadij Raivich, Michael Willem, Ulrike Mayer, Georg W. Kreutzberg
Publikováno v:
The Journal of Neuroscience. 20:1822-1830
The interplay between growing axons and the extracellular substrate is pivotal for directing axonal outgrowth during development and regeneration. Here we show an important role for the neuronal cell adhesion molecule alpha7beta1 integrin during peri
Autor:
Leonard L. Jones, Alexander Werner, Georg W. Kreutzberg, Jun Shen, ZhiQiang Liu, Gennadij Raivich
Publikováno v:
The Journal of Comparative Neurology. 426:468-492
CD44 is a cell surface glycoprotein involved in cell adhesion during neurite outgrowth, leukocyte homing, and tumor metastasis. In the current study, we examined the regulation of this molecule 4 days after neural trauma in different forms of central