Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Leonard Khiroug"'
Publikováno v:
Pain Research and Management, Vol 2023 (2023)
Externí odkaz:
https://doaj.org/article/6eeb7a64b815499a8551d8013db07957
Autor:
Laurent Pradier, Véronique Blanchard-Brégeon, Andrees Bohme, Thomas Debeir, Jean Menager, Patrick Benoit, Pascal Barneoud, Véronique Taupin, Philippe Bertrand, Philippe Dugay, Béatrice Cameron, Yi Shi, Souad Naimi, Marc Duchesne, Marie Gagnaire, Tim Weeden, Tara Travaline, David Reczek, Leonard Khiroug, Mohamed Slaoui, Pascale Brunel, Hidehiro Fukuyama, Jeffrey Ravetch, Thierry Canton, Caroline Cohen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-23 (2018)
Abstract Background Anti-amyloid β (Aβ) immunotherapy represents a major area of drug development for Alzheimer’s disease (AD). However, Aβ peptide adopts multiple conformations and the pathological forms to be specifically targeted have not bee
Externí odkaz:
https://doaj.org/article/8e1251be3bb94110879a8c1cd6a6d727
Autor:
Hanna Antila, Maria Ryazantseva, Dina Popova, Pia Sipilä, Ramon Guirado, Samuel Kohtala, Ipek Yalcin, Jesse Lindholm, Liisa Vesa, Vinicius Sato, Joshua Cordeira, Henri Autio, Mikhail Kislin, Maribel Rios, Sâmia Joca, Plinio Casarotto, Leonard Khiroug, Sari Lauri, Tomi Taira, Eero Castrén, Tomi Rantamäki
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthe
Externí odkaz:
https://doaj.org/article/9b0a9c01a2904ac9a4a5d9e945138f61
Autor:
Weilun Sun, Kunimichi Suzuki, Dmytro Toptunov, Stoyan Stoyanov, Michisuke Yuzaki, Leonard Khiroug, Alexander Dityatev
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Two-photon imaging of fluorescently labeled microglia in vivo provides a direct approach to measure motility of microglial processes as a readout of microglial function that is crucial in the context of neurodegenerative diseases, as well as to under
Externí odkaz:
https://doaj.org/article/e84e15406bc94ff8b62211ba6d6dde3b
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
In this mini-review, we summarize recent discoveries and present new hypotheses on the role of cannabinoids in controlling trigeminal nociceptive system underlying migraine pain. Individual sections of this review cover key aspects of this topic, suc
Externí odkaz:
https://doaj.org/article/b71522d5ae6747f5b3200801c426395c
Autor:
Habib Baghirov, Didem Karaman, Tapani Viitala, Alain Duchanoy, Yan-Ru Lou, Veronika Mamaeva, Evgeny Pryazhnikov, Leonard Khiroug, Catharina de Lange Davies, Cecilia Sahlgren, Jessica M Rosenholm
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160705 (2016)
Drug delivery into the brain is impeded by the blood-brain-barrier (BBB) that filters out the vast majority of drugs after systemic administration. In this work, we assessed the transport, uptake and cytotoxicity of promising drug nanocarriers, mesop
Externí odkaz:
https://doaj.org/article/daf05b57f32a4e1ab5ea26d761f1a879
Autor:
Laura Ahtiainen, Julia Kolikova, Aino-Liisa Mutka, Kaisu Luiro, Massimiliano Gentile, Elina Ikonen, Leonard Khiroug, Anu Jalanko, Outi Kopra
Publikováno v:
Neurobiology of Disease, Vol 28, Iss 1, Pp 52-64 (2007)
Infantile neuronal ceroid lipofuscinosis (INCL) is a severe neurodegenerative disorder of children, characterized by selective death of neocortical neurons. To understand early disease mechanisms in INCL, we have studied Ppt1Deltaex4 knock-out mouse
Externí odkaz:
https://doaj.org/article/aa3440668f314b2eabfc140a5328b79c
Autor:
Evgeny Pryazhnikov, Mikhail Kislin, Marina Tibeykina, Dmytro Toptunov, Anna Ptukha, Artem Shatillo, Olli Gröhn, Rashid Giniatullin, Leonard Khiroug
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89699 (2014)
Vascular changes underlying headache in migraine patients induced by Glyceryl trinitrate (GTN) were previously studied with various imaging techniques. Despite the long history of medical and experimental use of GTN, its effects on the brain vasculat
Externí odkaz:
https://doaj.org/article/2d126caee6e8433aa49498e30e84328e
Autor:
Anna Fedotova, Alexey Brazhe, Maxim Doronin, Dmitro Toptunov, Evgeny Pryazhnikov, Leonard Khiroug, Alexei Verkhratsky, Alexey Semyanov
Publikováno v:
Function.
Orchestrated activity of different cell types and their interactions within the brain active milieu provide the cellular basis for brain functions. Locomotion triggers a coordinated response of both neurons and astrocytes in various brain regions. He
Publikováno v:
Drug discovery today. 27(11)
Significant efforts have been channeled into developing antibodies for the treatment of CNS indications. Disappointment with the first generation of clinical Tau antibodies in Alzheimer's disease has highlighted the challenges in understanding whethe