Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Leonard Katz"'
Autor:
Elias Englund, Matthias Schmidt, Alberto A. Nava, Sarah Klass, Leah Keiser, Qingyun Dan, Leonard Katz, Satoshi Yuzawa, Jay D. Keasling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Type I modular polyketide synthases (PKSs) are multi-domain enzymes functioning like assembly lines. Many engineering attempts have been made for the last three decades to replace, delete and insert new functional domains into PKSs to produc
Externí odkaz:
https://doaj.org/article/cac6e64bfec142468a38c3090a80d780
Autor:
Satoshi Yuzawa, Mona Mirsiaghi, Renee Jocic, Tatsuya Fujii, Fabrice Masson, Veronica T. Benites, Edward E. K. Baidoo, Eric Sundstrom, Deepti Tanjore, Todd R. Pray, Anthe George, Ryan W. Davis, John M. Gladden, Blake A. Simmons, Leonard Katz, Jay D. Keasling
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Mutating natural enzymes is effective in broadening the substrate or product range, but generally leads to reduced titers. Here the authors engineer hybrid polyketide synthases for efficient production of short-chain ketones from plant biomass hydrol
Externí odkaz:
https://doaj.org/article/43191a49361742d58a6a635e4ab9761b
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109421 (2014)
Acyltransferases determine which extender units are incorporated into polyketide and fatty acid products. The ping-pong acyltransferase mechanism utilizes a serine in a conserved GHSxG motif. However, the role of the conserved histidine in this motif
Externí odkaz:
https://doaj.org/article/edc52e1d3a2e438aadd7143e45c169df
Autor:
Leonard Katz
Publikováno v:
The Scientific World Journal, Vol 2, Pp 127-129 (2002)
Externí odkaz:
https://doaj.org/article/3b23058456ce41e088f66d948261c36f
Autor:
Elias Englund, Matthias Schmidt, Alberto A. Nava, Anna Lechner, Kai Deng, Renee Jocic, Yingxin Lin, Jacob Roberts, Veronica T. Benites, Ramu Kakumanu, Jennifer W. Gin, Yan Chen, Yuzhong Liu, Christopher J. Petzold, Edward E. K. Baidoo, Trent R. Northen, Paul D. Adams, Leonard Katz, Satoshi Yuzawa, Jay D. Keasling
Publikováno v:
Journal of the American Chemical Society : JACS 145(16), 8822-8832 (2023). doi:10.1021/jacs.2c11027
Englund, E, Schmidt, M, Nava, A A, Lechner, A, Deng, K, Jocic, R, Lin, Y, Roberts, J, Benites, V T, Kakumanu, R, Gin, J W, Chen, Y, Liu, Y, Petzold, C J, Baidoo, E E K, Northen, T R, Adams, P D, Katz, L, Yuzawa, S & Keasling, J D 2023, ' Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase ', Journal of the American Chemical Society, vol. 145, no. 16, pp. 8822-8832 . https://doi.org/10.1021/jacs.2c11027
Journal of the American Chemical Society, vol 145, iss 16
Englund, E, Schmidt, M, Nava, A A, Lechner, A, Deng, K, Jocic, R, Lin, Y, Roberts, J, Benites, V T, Kakumanu, R, Gin, J W, Chen, Y, Liu, Y, Petzold, C J, Baidoo, E E K, Northen, T R, Adams, P D, Katz, L, Yuzawa, S & Keasling, J D 2023, ' Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase ', Journal of the American Chemical Society, vol. 145, no. 16, pp. 8822-8832 . https://doi.org/10.1021/jacs.2c11027
Journal of the American Chemical Society, vol 145, iss 16
Journal of the American Chemical Society : JACS 145(16), 8822-8832 (2023). doi:10.1021/jacs.2c11027
Published by American Chemical Society Publications, Washington, DC
Published by American Chemical Society Publications, Washington, DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c971887b3df730f910a42b92d61ae6d7
Autor:
Elias Englund, Matthias Schmidt, Alberto Nava, Qingyun Dan, Leonard Katz, Satoshi Yuzawa, Jay Keasling
Type I modular polyketide synthases (PKSs) are multi-domain enzymes functioning like assembly lines. Many engineering attempts have been made for the last three decades to replace, delete and insert new functional domains into PKSs to produce novel m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfd62a62db82ce22a702e3098ebae32b
https://doi.org/10.21203/rs.3.rs-1528836/v1
https://doi.org/10.21203/rs.3.rs-1528836/v1
Autor:
Aindrila Mukhopadhyay, Yuzhong Liu, Ravi Lal, Rasha Anayah, Pablo Cruz-Morales, Amin Zargar, Mitchell G. Thompson, Jay D. Keasling, Carolina Barcelos, Arthur Loubat, Jessica Wang, Christopher J. Petzold, Andrew R. Wong, Veronica T. Benites, Jesus F. Barajas, Yan Chen, Miranda Werts, Luis E. Valencia, Samantha Chang, Edward E. K. Baidoo, Amanda C. Hernández, Ankita Kothari, Tyler W. H. Backman, Constance B. Bailey, Leonard Katz, Hector Garcia Martin
Publikováno v:
BIRD: BCAM's Institutional Repository Data
instname
Journal of the American Chemical Society, vol 142, iss 22
instname
Journal of the American Chemical Society, vol 142, iss 22
Polyketide synthase (PKS) engineering is an attractive method to generate new molecules such as commodity, fine and specialty chemicals. A significant challenge in PKS design is engineering a partially reductive module to produce a saturated β-carbo
Autor:
Miranda Werts, Veronica T. Benites, Luis E. Valencia, Samantha Chang, Ravi Lal, Jay D. Keasling, Andrew R. Wong, Amin Zargar, Leonard Katz, Edward E. K. Baidoo, Jessica Wang
Traditionally engineered to produce novel bioactive molecules, Type I modular polyketide synthases (PKSs) could be engineered as a new biosynthetic platform for the production of de novo fuels, commodity chemicals, and specialty chemicals. Previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d41a30022feb623844e1176c0a778c
https://doi.org/10.1101/2020.05.14.096743
https://doi.org/10.1101/2020.05.14.096743
Autor:
Andrew R. Wong, Miranda Werts, Jessica Wang, Edward E. K. Baidoo, Veronica T. Benites, Ravi Lal, Leonard Katz, Luis E. Valencia, Amanda C. Hernández, Amin Zargar, Samantha Chang, Jay D. Keasling
Publikováno v:
Zargar, A, Valencia, L, Wang, J, Lal, R, Chang, S, Werts, M, Wong, A R, Hernández, A C, Benites, V, Baidoo, E E K, Katz, L & Keasling, J D 2020, ' A bimodular PKS platform that expands the biological design space ', Metabolic Engineering, vol. 61, pp. 389-396 . https://doi.org/10.1016/j.ymben.2020.07.001
Traditionally engineered to produce novel bioactive molecules, Type I modular polyketide synthases (PKSs) could be engineered as a new biosynthetic platform for the production of de novo fuels, commodity chemicals, and specialty chemicals. Previously
Autor:
Christopher J. Petzold, Paul D. Adams, Leonard Katz, Edward E. K. Baidoo, Jose Henrique Pereira, Jay D. Keasling, Yan Chen, Jennifer W. Gin, Danika Nimlos, Jeffrey Chen, Catalina Alonso-Martinez, Rohith N. Krishna, Pablo Cruz-Morales, Leanne Jade G. Chan, Jesus F. Barajas, Jacquelyn M. Blake-Hedges, Mitchell G. Thompson
Publikováno v:
Journal of the American Chemical Society, vol 142, iss 2
Blake-Hedges, J M, Pereira, J H, Cruz-Morales, P, Thompson, M G, Barajas, J F, Chen, J, Krishna, R N, Chan, L J G, Nimlos, D, Alonso-Martinez, C, Baidoo, E E K, Chen, Y, Gin, J W, Katz, L, Petzold, C J, Adams, P D & Keasling, J D 2020, ' Structural Mechanism of Regioselectivity in an Unusual Bacterial Acyl-CoA Dehydrogenase ', Journal of the American Chemical Society, vol. 142, no. 2, pp. 835-846 . https://doi.org/10.1021/jacs.9b09187
Blake-Hedges, J M, Pereira, J H, Cruz-Morales, P, Thompson, M G, Barajas, J F, Chen, J, Krishna, R N, Chan, L J G, Nimlos, D, Alonso-Martinez, C, Baidoo, E E K, Chen, Y, Gin, J W, Katz, L, Petzold, C J, Adams, P D & Keasling, J D 2020, ' Structural Mechanism of Regioselectivity in an Unusual Bacterial Acyl-CoA Dehydrogenase ', Journal of the American Chemical Society, vol. 142, no. 2, pp. 835-846 . https://doi.org/10.1021/jacs.9b09187
Terminal alkenes are easily derivatized, making them desirable functional group targets for polyketide synthase (PKS) engineering. However, they are rarely encountered in natural PKS systems. One mechanism for terminal alkene formation in PKSs is thr