Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Leonard K. Kaczmarek"'
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113904- (2024)
Summary: The KCNT1 gene encodes the sodium-activated potassium channel Slack (KCNT1, KNa1.1), a regulator of neuronal excitability. Gain-of-function mutations in humans cause cortical network hyperexcitability, seizures, and severe intellectual disab
Externí odkaz:
https://doaj.org/article/7ce18ab716354d34997ccd823b860e4f
Autor:
Yalan Zhang, Luis Varela, Klara Szigeti-Buck, Adam Williams, Milan Stoiljkovic, Matija Šestan-Peša, Jorge Henao-Mejia, Pasquale D’Acunzo, Efrat Levy, Richard A. Flavell, Tamas L. Horvath, Leonard K. Kaczmarek
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
How the activity of the neuronal Kv3.3 voltage-dependent channel is regulated is unclear. Here, the authors show that the known Kv3.3 channel complex with Hax1, which affects spinal cerebellar ataxia, regulates the enzyme Tank Binding Kinase 1, modul
Externí odkaz:
https://doaj.org/article/13d7eef65e4645d8b409edf85235aea3
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/cb39aeefa6fb417cb14e5b026f6c4fa0
Autor:
Jing Wu, Leonard K. Kaczmarek
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The extraction and localization of an auditory stimulus of interest from among multiple other sounds, as in the ‘cocktail-party’ situation, requires neurons in auditory brainstem nuclei to encode the timing, frequency, and intensity of sounds wit
Externí odkaz:
https://doaj.org/article/1061d4fcf8ff476fb8a98cc25bbdb494
Autor:
Amy F.T. Arnsten, Lu E. Jin, Nao J. Gamo, Brian Ramos, Constantinos D. Paspalas, Yury M. Morozov, Anna Kata, Nigel S. Bamford, Mark F. Yeckel, Leonard K. Kaczmarek, Lynda El-Hassar
Publikováno v:
Neurobiology of Stress, Vol 11, Iss , Pp - (2019)
The prefrontal cortex (PFC) mediates higher cognition but is impaired by stress exposure when high levels of catecholamines activate calcium-cAMP-protein kinase A (PKA) signaling. The current study examined whether stress and increased cAMP-PKA signa
Externí odkaz:
https://doaj.org/article/e489f815cedc44b7b83cd24a6d9b2696
Autor:
Marco Onorati, Zhen Li, Fuchen Liu, André M.M. Sousa, Naoki Nakagawa, Mingfeng Li, Maria Teresa Dell’Anno, Forrest O. Gulden, Sirisha Pochareddy, Andrew T.N. Tebbenkamp, Wenqi Han, Mihovil Pletikos, Tianliuyun Gao, Ying Zhu, Candace Bichsel, Luis Varela, Klara Szigeti-Buck, Steven Lisgo, Yalan Zhang, Anze Testen, Xiao-Bing Gao, Jernej Mlakar, Mara Popovic, Marie Flamand, Stephen M. Strittmatter, Leonard K. Kaczmarek, E.S. Anton, Tamas L. Horvath, Brett D. Lindenbach, Nenad Sestan
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2576-2592 (2016)
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroep
Externí odkaz:
https://doaj.org/article/7ed0523b8c024cdea2dcfa2c3cd7c835
Autor:
Matthew R. Fleming, Maile R. Brown, Jack Kronengold, Yalan Zhang, David P. Jenkins, Gulia Barcia, Rima Nabbout, Anne E. Bausch, Peter Ruth, Robert Lukowski, Dhasakumar S. Navaratnam, Leonard K. Kaczmarek
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2281-2288 (2016)
Human mutations in the cytoplasmic C-terminal domain of Slack sodium-activated potassium (KNa) channels result in childhood epilepsy with severe intellectual disability. Slack currents can be increased by pharmacological activators or by phosphorylat
Externí odkaz:
https://doaj.org/article/2cfbf9c489e94d12aaac50269099564c
Autor:
Grace E. Kim, Jack Kronengold, Giulia Barcia, Imran H. Quraishi, Hilary C. Martin, Edward Blair, Jenny C. Taylor, Olivier Dulac, Laurence Colleaux, Rima Nabbout, Leonard K. Kaczmarek
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1661-1672 (2014)
Summary: Disease-causing mutations in ion channels generally alter intrinsic gating properties such as activation, inactivation, and voltage dependence. We examined nine different mutations of the KCNT1 (Slack) Na+-activated K+ channel that give rise
Externí odkaz:
https://doaj.org/article/b3b7f5cb5f9248f5b7c8c44c8cac32e9
Autor:
Grace E. Kim, Leonard K. Kaczmarek
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
The sodium-activated potassium KNa channels Slack and Slick are encoded by KCNT1 and KCNT2, respectively. These channels are found in neurons throughout the brain, and are responsible for a delayed outward current termed IKNa. These currents integrat
Externí odkaz:
https://doaj.org/article/6db16dc4e6dd4c4ba4ab5699c2f4efd5
Autor:
Wei eWang, Adhytia ePutra, Gary P. Schools, Baofeng eMa, Haijun eChen, Leonard K. Kaczmarek, Jacques eBarhanin, Florian eLesage, Min eZhou
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 7 (2013)
TWIK-1 two-pore domain K+ channels are expressed abundantly in astrocytes. In the present study, we examined the extent to which TWIK-1 contributes to the linear current-voltage (I-V) relationship (passive) K+ membrane conductance, a dominant electro
Externí odkaz:
https://doaj.org/article/4cd7d438536e4140afce111027883088