Výsledky vyhledávání - "Leonard Joseph Lescosky"

Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]-quinoxaline-2,3-dione and related quinoxalinediones: characterization of .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity

Autor: Daniel F. Ortwine, Peter A. Boxer, Leonard Joseph Lescosky, S. A. Borosky, Daniel Martin Retz, C.B. Nelson, Thomas Charles Malone, Christopher F. Bigge, Mark G. Vartanian, Schelkun Robert Michael

Publikováno v: Journal of Medicinal Chemistry. 38:3720-3740

Four related series of substituted quinoxalinediones containing angular fused-piperidine rings have been synthesized as α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists with potential as neuroprotective agents, primar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe1f78653faecd9283d29ff86e0bbd8
https://doi.org/10.1021/jm00019a003

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NS 257 (1,2,3,6,7,8-hexahydro-3(hydroxyimino)-N,N,7-trimethyl-2-oxobenzo[2,1-b:3,4-c']dipyrrole-5-sulfonamide) is a potent, systemically active ampa receptor antagonist

Autor: Thomas Charles Malone, Gregory W. Campbell, Elsebet Ø. Nielsen, Peter A. Boxer, Jorgen Drejer, Christopher F. Bigge, Frank Wätjen, Frank W. Marcoux, David M. Rock, Leif Helth Jensen, Leonard Joseph Lescosky, Linda L. Coughenour

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:371-376

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8c346721d74ca36cf753dffe53bc279
https://doi.org/10.1016/s0960-894x(01)80147-5

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ChemInform Abstract: NS 257 (1,2,3,6,7,8-Hexahydro-3(hydroxyimino)-N,N,7-trimethyl-2- oxobenzo(2,1-b:3,4-c′)dipyrrole-5-sulfonamide) is a Potent, Systemically Active AMPA Receptor Antagonist

Autor: Leonard Joseph Lescosky, Peter A. Boxer, Christopher F. Bigge, E. Oe. Nielen, Thomas Charles Malone, David M. Rock, Gregory W. Campbell, Frank W. Marcoux, F. Waetjen, L. H. Jensen, J. Drejer, Linda L. Coughenour

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c38063053e43445d1cf35f12d1ae9f8
https://doi.org/10.1002/chin.199427105

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ChemInform Abstract: Synthesis of 1,4,7,8,9,10-Hexahydro-9-methyl-6-nitropyrido(3,4-f) quinoxaline-2,3-dione and Related Quinoxalinediones: Characterization of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) and N-Methyl-D-aspartate (NMDA) Rec

Autor: Mark G. Vartanian, Gregory W. Campbell, Christopher F. Bigge, Daniel F. Ortwine, Roy D. Schwarz, Peter A. Boxer, Schelkun Robert Michael, Lillian J. Robichaud, S. A. Borosky, D. M. Retz, Thomas Charles Malone, Leonard Joseph Lescosky, F. Waetjen, C.B. Nelson

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba446b1cb6d0230e4edfbb4863c69962
https://doi.org/10.1002/chin.199603167

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