Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Leonard J. Rubinstein"'
Autor:
Katrina M. Nolan, Brent Seaton, Joseph Antonello, Yuhua Zhang, Lauren Cook, Krystyn Delfino, Leonard J. Rubinstein, Kyeongmi Cheon, Thomas Group, Alain Luxembourg, Sheri Dubey
Publikováno v:
mSphere, Vol 8, Iss 2 (2023)
ABSTRACT Two multiplex immunoassays are routinely used to assess antibody responses in clinical trials of the 9-valent human papillomavirus (9vHPV) vaccine. The HPV6/11/16/18/31/33/45/52/58 competitive Luminex immunoassay (HPV-9 cLIA) and HPV6/11/16/
Externí odkaz:
https://doaj.org/article/fc915b5b917b4300a7a5ca8400155d0e
Autor:
Gowrisankar Rajam, Yuhua Zhang, Joseph M. Antonello, Rebecca J. Grant-Klein, Lauren Cook, Reshma Panemangalore, Huy Pham, Stephanie Cooper, Thomas D. Steinmetz, Jennifer Nguyen, Mathias W. Pletz, Grit Barten-Neiner, Rocio D. Murphy, Leonard J. Rubinstein, Katrina M. Nolan
Publikováno v:
mSphere, Vol 7, Iss 4 (2022)
ABSTRACT Streptococcus pneumoniae is a major cause of community-acquired pneumonia (CAP) in young children, older adults, and those with immunocompromised status. Since the introduction of pneumococcal vaccines, the burden of invasive pneumococcal di
Externí odkaz:
https://doaj.org/article/54c92dbec88d43e1b1ac8f0c54ada833
Autor:
Leonard J. Rubinstein, Kevin B. Gurney, Sarah Daijogo, Joseph M. Antonello, Bogardus Leah A, Giacone Danila G, Dengyun Sun, Melissa C. Whiteman
Publikováno v:
The American Journal of Tropical Medicine and Hygiene
Vaccine immunogenicity and clinical efficacy are often assessed by the measure of serum-neutralizing antibodies. The present gold standard for detecting neutralizing antibodies against many viruses, including dengue, is the plaque/focus reduction neu
Publikováno v:
Bioanalysis. 13(5)
Aim: For oncolytic virus trials, regulatory agencies often require pharmaceutical industry to evaluate risks of released viruses from patients to environment. This study was to establish a real-time PCR method to assess viral shedding and viral stabi
Autor:
Shara Dellatore, Bogardus Leah A, Dengyun Sun, Leonard J. Rubinstein, Kevin B. Gurney, Amy Hsu, Melissa C. Whiteman, Joseph M. Antonello
Publikováno v:
Journal of Immunological Methods. 494:113054
Respiratory syncytial virus (RSV) is a common pathogen causing severe respiratory illness in infants and elder adults. The development of an effective RSV vaccine is an important unmet medical need and an area of active research. The traditional meth
Publikováno v:
Journal of Immunoassay and Immunochemistry. 29:332-347
Immunogenicity is often a critical clinical endpoint in the assessment of vaccines prior to the submission of data to regulatory agencies. As a result, the assays used to measure immunogenicity must be highly characterized, well-controlled, and stati
Autor:
Martha E. Monser, Harold J. Jennings, Pablo A. García-Ojeda, Leonard J. Rubinstein, Kathryn E. Stein
Publikováno v:
Infection and Immunity. 68:239-246
Antibody (Ab) responses to polysaccharides (PSs) such asNeisseria meningitidisgroup C PS (MCPS) are characterized as being thymus independent (TI) and are restricted with regard to clonotype and isotype expression. PS conjugated to proteins, e.g., MC
Autor:
Derek Puchalski, Leonard J. Rubinstein, Daniel Sikkema, Rocio D. Marchese, Tina Green, Pamela Miller, Joseph M. Antonello, Olivia Hammond, Michael J. Caulfield
Publikováno v:
Clinical and vaccine immunology : CVI. 16(3)
Pneumovax 23 consists of a mixture of highly purified capsular polysaccharides (Ps) from 23 of the most prevalent serotypes of Streptococcus pneumoniae . Testing of vaccine immunogenicity has been historically performed on the enzyme-linked immunosor
Publikováno v:
International Reviews of Immunology. 4:321-336
(1989). The Role of the A48 Regulatory Idiotype in Inducing Tumor-Specific Immunity. International Reviews of Immunology: Vol. 4, No. 4, pp. 321-336.
Publikováno v:
European Journal of Immunology. 19:2361-2365
Anti-idiotypic (Id) antibodies provide a means other than antigen of clone-specific regulation of immune responses, and have been proposed as an alternative form of vaccine. However, the requirements for effective induction of immunity by anti-Id are