Zobrazeno 1 - 10
of 32 111
pro vyhledávání: '"Leonard J"'
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-19 (2024)
Abstract Recent advances in uncovering the mysteries of the human genome suggest that long non-coding RNAs (lncRNAs) are important regulatory components. Although lncRNAs are known to affect gene transcription, their mechanisms and biological implica
Externí odkaz:
https://doaj.org/article/5c2cd988508e4f7faee9f66d3d5b640e
Autor:
Leonard J. Ash, Ottavia Busia-Bourdain, Daniel Okpattah, Avrosina Kamel, Ariel Liberchuk, Andrew L. Wolfe
Publikováno v:
Current Oncology, Vol 31, Iss 4, Pp 2024-2046 (2024)
KRAS is a small GTPase that is among the most commonly mutated oncogenes in cancer. Here, we discuss KRAS biology, therapeutic avenues to target it, and mechanisms of resistance that tumors employ in response to KRAS inhibition. Several strategies ar
Externí odkaz:
https://doaj.org/article/b47ee29068f2470eb7fd8add47c5bb63
Autor:
Nuria Morfin, Leonard J. Foster, Ernesto Guzman-Novoa, Paul Van Westendorp, Robert W. Currie, Heather Higo
Publikováno v:
Frontiers in Bee Science, Vol 2 (2024)
IntroductionThe honey bee parasitic mite, Varroa destructor, is considered the main factor associated with winter colony losses. To control this mite, beekeepers must implement Integrated Pest Management (IPM) strategies. An effective IPM strategy is
Externí odkaz:
https://doaj.org/article/8847a4820ba04c68bac8dbeca6ad7cfa
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract We present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and inter
Externí odkaz:
https://doaj.org/article/d541b789500840e8affe27b782bc61b7
Autor:
Brian S. Adams, Dominic J. Marino, Catherine A. Loughin, Leonard J. Marino, Teresa Southard, Martin L. Lesser, Meredith Akerman, Patrick Roynard
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
ObjectiveTo determine if a single brain biopsy utilizing a freeze-core needle harvest system Cassi II under ultrasound guidance provides a diagnostic sample; to evaluate the technique's efficacy in procuring diagnostic samples in comparison with “o
Externí odkaz:
https://doaj.org/article/93a3adca3be34b54b519cbf55e6eb599
Autor:
Víctor Torres, Víctor Contreras, Bessy Gutiérrez, Juan San Francisco, Alejandro Catalán, José Luis Vega, Kyung-Mee Moon, Leonard J. Foster, Rafael F. de Almeida, Alexis M. Kalergis, Jorge González
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionOral transmission of T. cruzi is probably the most frequent transmission mechanism in wild animals. This observation led to the hypothesis that consuming raw or undercooked meat from animals infected with T. cruzi may be responsible for t
Externí odkaz:
https://doaj.org/article/f4f5aa49bde24e818511dc3d39a65ba6
Autor:
Lílian Caesar, Danny W. Rice, Alison McAfee, Robyn Underwood, Carrie Ganote, David R. Tarpy, Leonard J. Foster, Irene L. G. Newton
Publikováno v:
mSystems, Vol 9, Iss 2 (2024)
ABSTRACTIn eusocial insects, the health of the queens—the colony founders and sole reproductive females—is a primary determinant for colony success. Queen failure in the honey bee Apis mellifera, for example, is a major concern of beekeepers who
Externí odkaz:
https://doaj.org/article/643172ffc82e4d96bcf8f2ea114b45ad
Publikováno v:
Therapeutics and Clinical Risk Management, Vol Volume 19, Pp 745-753 (2023)
Heather D Anderson,1 Vanessa Paul Patterson,1 Garth Wright,1 Julia E Rawlings,1 Gina D Moore,1 Jim Leonard,2 Robert L Page II1 1Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Anschutz Me
Externí odkaz:
https://doaj.org/article/f27f86c8ecf1410fa7198c68436279f5
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-71 (2023)
Abstract Undruggable proteins are a class of proteins that are often characterized by large, complex structures or functions that are difficult to interfere with using conventional drug design strategies. Targeting such undruggable targets has been c
Externí odkaz:
https://doaj.org/article/092a576020c3445a9ad55aa2e344ae05
Autor:
Yinhan Luo, Sina Safabakhsh, Alessia Palumbo, Céline Fiset, Carol Shen, Jeremy Parker, Leonard J. Foster, Zachary Laksman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5964 (2024)
Males and females exhibit intrinsic differences in the structure and function of the heart, while the prevalence and severity of cardiovascular disease vary in the two sexes. However, the mechanisms of this sex-based dimorphism are yet to be elucidat
Externí odkaz:
https://doaj.org/article/a02d5295efc24761a1fb5f14d7a58da6