Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Leonard I. Wiebe"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 323 (2024)
Most antiviral and anticancer nucleosides are prodrugs that require stepwise phosphorylation to their triphosphate nucleotide form for biological activity. Monophosphorylation may be rate-limiting, and the nucleotides may be unstable and poorly inter
Externí odkaz:
https://doaj.org/article/4b6943cd81af4df299dfbf4056fbdc1b
Autor:
Hans-S. Jans, Daria Stypinski, Piyush Kumar, John R. Mercer, Stephen A. McQuarrie, Alexander J. B. McEwan, Leonard I. Wiebe
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1655 (2022)
Theragnostic pairs of isotopes are used to infer radiation dosimetry for a therapeutic radiopharmaceutical from a diagnostic imaging study with the same tracer molecule labelled with an isotope better suited for the imaging task. We describe the tran
Externí odkaz:
https://doaj.org/article/08ade0397d0f4f4484e00d44c51626a5
Publikováno v:
Molecules, Vol 25, Iss 23, p 5700 (2020)
Vitamin E, a natural antioxidant, is of interest to scientists, health care pundits and faddists; its nutritional and biomedical attributes may be validated, anecdotal or fantasy. Vitamin E is a mixture of tocopherols (TPs) and tocotrienols (T-3s), e
Externí odkaz:
https://doaj.org/article/6b21d1c505d74ac1a5aef96427d127ae
Publikováno v:
Pharmaceuticals, Vol 12, Iss 1, p 3 (2019)
Introduction: Benzotriazine-1,4-dioxides (BTDOs) such as tirapazamine (TPZ) and its derivatives act as radiosensitizers of hypoxic tissues. The benzotriazine-1-monoxide (BTMO) metabolite (SR 4317, TPZMO) of TPZ also has radiosensitizing properties, a
Externí odkaz:
https://doaj.org/article/7bad207505924d6a9de0269ae9ba4e73
Publikováno v:
Pharmaceutics, Vol 10, Iss 1, p 25 (2018)
The objective of this work is to evaluate the potential effect of cardiac stress exercise on the accumulation of [123I]IAZA, a radiopharmaceutical used to image focal tissue hypoxia, in otherwise normal myocardium in healthy volunteers, and to determ
Externí odkaz:
https://doaj.org/article/76d3348afd29406ea5f93123e8eb992b
Autor:
Leonard I. Wiebe
Publikováno v:
Brazilian Archives of Biology and Technology, Vol 50, Iss 3, Pp 445-459 (2007)
Positron emission tomography (PET) is a non-invasive nuclear imaging technique. In PET, radiolabelled molecules decay by positron emission. The gamma rays resulting from positron annihilation are detected in coincidence and mapped to produce three di
Externí odkaz:
https://doaj.org/article/8285360122274c83a61e5ff60bd2e781
Publikováno v:
Brazilian Archives of Biology and Technology, Vol 45, Iss spe, Pp 69-81 (2002)
Affected tissues in a number of diseases, including cancer, stroke, cardiac infarction and diabetes, develop focal tissue hypoxia during their progression. The presence of hypoxic tissue may make the disease refractory to therapy, as in the case of s
Externí odkaz:
https://doaj.org/article/2cfbb697ac1541bfa77b28b80ca911c0
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 11, Iss 2 (2008)
PURPOSE. Iododeoxyuridine (IUdR) has a very short in vivo half-life and consequently achieves low target-tissue concentrations with concomitant lower efficacy than would be predicted from in vitro studies. This work reports the preparation of IUdR:?-
Externí odkaz:
https://doaj.org/article/d96cfad7b3184c7ba430c45b74979c11
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 23, Iss 1 (2020)
The reduction potentials of bioreductively-activated drugs represent an important design parameter to be accommodated in the course of creating lead compounds and improving the efficacy of older generation drugs. Reduction potentials are traditionall
Autor:
Ali Akbari, Manju Tandon, William Sun, Ebrahim Naimi, Piyush Kumar, Leonard I. Wiebe, Cheryl Falzon
Publikováno v:
Current Radiopharmaceuticals. 12:49-57
Background: 1-α-D-(5-Deoxy-5-[18F]fluoroarabinofuranosyl)-2-nitroimidazole ([18F]FAZA) is manufactured by nucleophilic radiofluorination of 1-α-D-(2’,3’-di-O-acetyl-5’-O-toluenesulfonylarabinofuranosyl)- 2-nitroimidazole (DiAcTosAZA) and alka