Zobrazeno 1 - 10
of 7 127
pro vyhledávání: '"Leonard I"'
Autor:
Haley R Noonan, Alexandra M Thornock, Julia Barbano, Michael E Xifaras, Chloe S Baron, Song Yang, Katherine Koczirka, Alicia M McConnell, Leonard I Zon
Publikováno v:
eLife, Vol 13 (2024)
Developmental signaling pathways associated with growth factors such as TGFb are commonly dysregulated in melanoma. Here we identified a human TGFb enhancer specifically activated in melanoma cells treated with TGFB1 ligand. We generated stable trans
Externí odkaz:
https://doaj.org/article/f51748881cd9498bbfd7139601c881b1
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Recently, δ 17O and its excess (Δ′17O) have become increasingly significant “triple-oxygen-isotope” indicators of distinctive hydrological processes in hydrology and climatology. This situation mirrors the research regarding δ 18O a
Externí odkaz:
https://doaj.org/article/c4b5ffe35df440a3be9fb9f262d3c611
Autor:
Luisbel González, Víctor Espinoza, Mauricio Tapia, Valentina Aedo, Isleidy Ruiz, Manuel Meléndrez, Claudio Aguayo, Leonard I. Atanase, Katherina Fernández
Publikováno v:
Gels, Vol 10, Iss 7, p 448 (2024)
In this study, an innovative conductive hybrid biomaterial was synthetized using collagen (COL) and reduced graphene oxide (rGO) in order for it to be used as a wound dressing. The hydrogels were plasticized with glycerol and enzymatically cross-link
Externí odkaz:
https://doaj.org/article/f8c4512f23204c4fa7be582dfd65760e
Publikováno v:
MethodsX, Vol 11, Iss , Pp 102283- (2023)
Compound-specific stable-isotope analysis (CSIA) of fatty acids is a powerful tool to better understand the trophic transfer of fatty acids and their biochemical fate in and across ecosystems, including tracing animal migration and understanding phys
Externí odkaz:
https://doaj.org/article/b5049041b9af41dabfeb57cec5d07cd8
Publikováno v:
Polymers, Vol 16, Iss 9, p 1189 (2024)
Smart polymeric micelles (PMs) are of great interest in drug delivery owing to their low critical micellar concentration and sizes. In the present study, two different pH-sensitive poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) copolymer
Externí odkaz:
https://doaj.org/article/abb0e27479054adf9760057df81354c3
Autor:
Camelia E. Iurciuc (Tincu), Marcel Popa, Leonard I. Atanase, Ovidiu Popa, Lacramioara Ochiuz, Paraschiva Postolache, Vlad Ghizdovat, Stefan A. Irimiciuc, Maricel Agop, Constantin Volovat, Simona Volovat
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 2883-2896 (2022)
The physicochemical properties of “smart” or stimuli-sensitive amphiphilic copolymers can be modeled as a function of their environment. In special, pH-sensitive copolymers have practical applications in the biomedical field as drug delivery syst
Externí odkaz:
https://doaj.org/article/fba5e529b59f49c69bf40b62f8c00816
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 323 (2024)
Most antiviral and anticancer nucleosides are prodrugs that require stepwise phosphorylation to their triphosphate nucleotide form for biological activity. Monophosphorylation may be rate-limiting, and the nucleotides may be unstable and poorly inter
Externí odkaz:
https://doaj.org/article/4b6943cd81af4df299dfbf4056fbdc1b
Publikováno v:
Polymers, Vol 16, Iss 4, p 499 (2024)
A new family of polyester-based copolymers—poly(sorbitol adipate-co-ethylene glycol adipate) (PSAEG), poly(sorbitol adipate-co-1,4 butane diol adipate) (PSABD), and poly (sorbitol adipate-co-1,6 hexane diol adipate) (PSAHD)—was obtained with a ca
Externí odkaz:
https://doaj.org/article/039ac5f741ff46b382d8fe5ee7be3756
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-6 (2022)
Abstract Tritium (3H) in Earth’s precipitation is vigilantly monitored since historical nuclear bomb tests because of radiological protection considerations and its invaluable role as a tracer of the global water cycle in quantifying surface, groun
Externí odkaz:
https://doaj.org/article/f8e8e6aff63f4a1e9b11bd0b8b525774
Autor:
Vera Binder, Wantong Li, Muhammad Faisal, Konur Oyman, Donn L. Calkins, Jami Shaffer, Emily M. Teets, Steven Sher, Andrew Magnotte, Alex Belardo, William Deruelle, T. Charles Gregory, Shelley Orwick, Elliott J. Hagedorn, Julie R. Perlin, Serine Avagyan, Asher Lichtig, Francesca Barrett, Michelle Ammerman, Song Yang, Yi Zhou, William E. Carson, Heather R. Shive, James S. Blachly, Rosa Lapalombella, Leonard I. Zon, Bradley W. Blaser
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112528- (2023)
Summary: Altered hematopoietic stem cell (HSC) fate underlies primary blood disorders but microenvironmental factors controlling this are poorly understood. Genetically barcoded genome editing of synthetic target arrays for lineage tracing (GESTALT)
Externí odkaz:
https://doaj.org/article/b0783af216d541e48c1e8e6815eda5bc