Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Leonard H. Wexler"'
Autor:
Henry de Traux de Wardin, Josephine K. Dermawan, Marie-Sophie Merlin, Leonard H. Wexler, Daniel Orbach, Fabio Vanoli, Gudrun Schleiermacher, Birgit Geoerger, Stelly Ballet, Delphine Guillemot, Eléonore Frouin, Stacy Cyrille, Olivier Delattre, Gaelle Pierron, Cristina R. Antonescu
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-13 (2023)
Abstract The genomic spectrum of rhabdomyosarcoma (RMS) progression from primary to relapse is not fully understood. In this pilot study, we explore the sensitivity of various targeted and whole-genome NGS platforms in order to assess the best genomi
Externí odkaz:
https://doaj.org/article/6f1928873e1d41818ff5568e4b5f0d3e
Autor:
Benjamin A. Nacev, Francisco Sanchez-Vega, Shaleigh A. Smith, Cristina R. Antonescu, Evan Rosenbaum, Hongyu Shi, Cerise Tang, Nicholas D. Socci, Satshil Rana, Rodrigo Gularte-Mérida, Ahmet Zehir, Mrinal M. Gounder, Timothy G. Bowler, Anisha Luthra, Bhumika Jadeja, Azusa Okada, Jonathan A. Strong, Jake Stoller, Jason E. Chan, Ping Chi, Sandra P. D’Angelo, Mark A. Dickson, Ciara M. Kelly, Mary Louise Keohan, Sujana Movva, Katherine Thornton, Paul A. Meyers, Leonard H. Wexler, Emily K. Slotkin, Julia L. Glade Bender, Neerav N. Shukla, Martee L. Hensley, John H. Healey, Michael P. La Quaglia, Kaled M. Alektiar, Aimee M. Crago, Sam S. Yoon, Brian R. Untch, Sarah Chiang, Narasimhan P. Agaram, Meera R. Hameed, Michael F. Berger, David B. Solit, Nikolaus Schultz, Marc Ladanyi, Samuel Singer, William D. Tap
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Sarcomas are rare tumours with many different subtypes and clinical outcomes; a broader knowledge of their genetic features is required. Here, the authors analyse 2138 soft tissue and bone sarcomas across 45 subtypes using MSK-IMPACT targeted sequenc
Externí odkaz:
https://doaj.org/article/89c42dddd0f647ee90d7805699d564f6
Autor:
Joseph Lopez, MD, MBA, Nancy Qin, BA, Robbie Woods, MD, Marjorie Golden, MFA, CDT, Harrison Spatz, DMD, MS, Jatin Shah, MD, Leonard H. Wexler, MD, Joseph Randazzo, DDS, Suzanne L. Wolden, MD, David H. Abramson, MD
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 10, Iss 10, p e4581 (2022)
SUMMARY. A 20-month-old boy presented with biopsy-proven recurrent alveolar rhabdomyosarcoma without metastasis. He was previously treated with multiagent chemotherapy and external beam irradiation showing a complete response. Upon relapse, he was tr
Externí odkaz:
https://doaj.org/article/cde7d09b3e494fec931a9f0a6b8f8ba8
Autor:
Lisa M. Kopp, Richard B. Womer, Cindy L. Schwartz, David H. Ebb, Vivian I. Franco, David Hall, Donald A. Barkauskas, Mark D. Krailo, Holcombe E. Grier, Paul A. Meyers, Leonard H. Wexler, Neyssa M. Marina, Katherine A. Janeway, Richard Gorlick, Mark L. Bernstein, Steven E. Lipshultz, for the Children’s Oncology Group
Publikováno v:
Cardio-Oncology, Vol 5, Iss 1, Pp 1-12 (2019)
Abstract Background Dexrazoxane protects from lower-cumulative-dose doxorubicin cardiotoxicity, but the effect of dexrazoxane in children with sarcoma treated with higher-cumulative-dose doxorubicin is unknown. Methods We evaluated children with oste
Externí odkaz:
https://doaj.org/article/c1df26e926ca40859f1f7499883d65cd
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Glypican 3 (GPC3) is a heparan sulfate proteoglycan and cell surface oncofetal protein which is highly expressed on a variety of pediatric solid embryonal tumors including the majority of hepatoblastomas, Wilms tumors, rhabdoid tumors, certain germ c
Externí odkaz:
https://doaj.org/article/11e246b6158c4d2bafc3c9d8aa0bdc7f
Autor:
Peter Anderson, Maurizio Ghisoli, Brian D. Crompton, Kelly S. Klega, Leonard H. Wexler, Emily K. Slotkin, Laura Stanbery, Luisa Manning, Gladice Wallraven, Meghan Manley, Staci Horvath, Ernest Bognar, John Nemunaitis
Publikováno v:
Clinical Cancer Research. 29:1689-1697
Purpose: Treatment options for recurrent or refractory Ewing's sarcoma (ES) are limited. Vigil is a novel autologous tumor cell therapy expressing bi-shRNA furin/GMCSF plasmid, which previously demonstrated monotherapy activity in advanced ES. Herein
Autor:
Yun Wei, Qian Qin, Chuan Yan, Madeline N. Hayes, Sara P. Garcia, Haibin Xi, Daniel Do, Alexander H. Jin, Tiffany C. Eng, Karin M. McCarthy, Abhinav Adhikari, Maristela L. Onozato, Dimitrios Spentzos, Gunnlaugur P. Neilsen, A. John Iafrate, Leonard H. Wexler, April D. Pyle, Mario L. Suvà, Filemon Dela Cruz, Luca Pinello, David M. Langenau
Publikováno v:
Nature Cancer. 3:961-975
Rhabdomyosarcoma (RMS) is a common childhood cancer that shares features with developing skeletal muscle. Yet, the conservation of cellular hierarchy with human muscle development and the identification of molecularly defined tumor-propagating cells
Autor:
John Nemunaitis, Ernest Bognar, Staci Horvath, Meghan Manley, Gladice Wallraven, Luisa Manning, Laura Stanbery, Emily K. Slotkin, Leonard H. Wexler, Kelly S. Klega, Brian D. Crompton, Maurizio Ghisoli, Peter Anderson
Background:Treatment options for recurrent or refractory Ewing's sarcoma (ES) are limited. Vigil is a novel autologous tumor cell therapy expressing bi-shRNA furin/GMCSF plasmid, which previously demonstrated monotherapy activity in advanced ES. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9c17819c5c38aa589d9eacee45a4a2
https://doi.org/10.1158/1078-0432.c.6533209.v2
https://doi.org/10.1158/1078-0432.c.6533209.v2
Supplementary Figure 1 from Comprehensive Molecular Profiling of Desmoplastic Small Round Cell Tumor
Autor:
Neerav Shukla, Marc Ladanyi, Ahmet Zehir, Elli Papaemmanuil, Andrew L. Kung, Paul A. Meyers, Leonard H. Wexler, Michael P. LaQuaglia, Todd E. Heaton, Justin T. Gerstle, Gunes Gundem, Daoqi You, Nancy Bouvier, Katherine A. Thornton, Mrinal M. Gounder, William D. Tap, Shakeel Modak, Nestor Rosales, Glorymar I. Sanchez, Diego F. Coutinho, Filemon Dela Cruz, Max F. Levine, Anita S. Bowman, Emily K. Slotkin
Supplementary Figure 1 depicts copy number alterations in the described cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8092c0a779e8af5f72ce9dfe30cdf632
https://doi.org/10.1158/1541-7786.22525995.v1
https://doi.org/10.1158/1541-7786.22525995.v1
Autor:
Neerav Shukla, Marc Ladanyi, Ahmet Zehir, Elli Papaemmanuil, Andrew L. Kung, Paul A. Meyers, Leonard H. Wexler, Michael P. LaQuaglia, Todd E. Heaton, Justin T. Gerstle, Gunes Gundem, Daoqi You, Nancy Bouvier, Katherine A. Thornton, Mrinal M. Gounder, William D. Tap, Shakeel Modak, Nestor Rosales, Glorymar I. Sanchez, Diego F. Coutinho, Filemon Dela Cruz, Max F. Levine, Anita S. Bowman, Emily K. Slotkin
Supplementary Table 1 shows point mutations found in DSRCT samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18101e727b13883957a6aa77461d9c6b
https://doi.org/10.1158/1541-7786.22525983
https://doi.org/10.1158/1541-7786.22525983