Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Leonard H. Evans"'
Autor:
Kathryn Haskins, Peter Dias, Roman Bashratyan, Yang D. Dai, Amanda Margosiak, Kristi Marquardt, Wen-Yuan Hu, Leonard H. Evans
Publikováno v:
Immunol Lett
Endogenous retrovirus (ERV) are remnants of ancient retroviruses that have been incorporated into the genome and evidence suggests that they may play a role in the etiology of T1D. We previously identified a murine leukemia retrovirus-like ERV whose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3e7d07bcb92bbeddf5be70cecf6ed9
https://pubmed.ncbi.nlm.nih.gov/32335144
https://pubmed.ncbi.nlm.nih.gov/32335144
Autor:
Diana S Smith, Kejun Guo, Bradley S Barrett, Karl J Heilman, Leonard H Evans, Kim J Hasenkrug, Warner C Greene, Mario L Santiago
Publikováno v:
PLoS Pathogens, Vol 7, Iss 10, p e1002284 (2011)
Members of the APOBEC3 family of deoxycytidine deaminases counteract a broad range of retroviruses in vitro through an indirect mechanism that requires virion incorporation and inhibition of reverse transcription and/or hypermutation of minus strand
Externí odkaz:
https://doaj.org/article/c55e999576e74449a8b3de8fc049b487
Autor:
Kyle Rosenke, Karin E. Peterson, Erik Van Dis, Leonard H. Evans, Stefano Boi, Morgan E. Ferrell, Ethan J. Hansen
Publikováno v:
Virology. 506:19-27
Clonal cell lines derived from cultures infected with a polytropic MuLV release vastly different levels of infectious virions ranging from undetectable to very high. Low producing clones release an overwhelming proportion of non-infectious virions co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884b309d12edabc46526b1aab5e78064
https://doi.org/10.1016/j.virol.2017.03.004
https://doi.org/10.1016/j.virol.2017.03.004
Publikováno v:
Virology. 518
Mouse APOBEC3 (mA3) is a cytidine deaminase that can act on the single-stranded DNA reverse transcripts of retroviruses resulting in G→A hypermutation of proviral DNA. Many mA3 studies have used NIH 3T3 cells assuming that endogenous mA3 production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2413b4077c234f82ee219702107d29
https://pubmed.ncbi.nlm.nih.gov/29605684
https://pubmed.ncbi.nlm.nih.gov/29605684
Autor:
Joyce Shepard, Stefano Boi, Erik Van Dis, Kyle Rosenke, Angelo Kolokithas, Rebecca Linwood, Frank Malik, Leonard H. Evans
Publikováno v:
Journal of Virology. 88:7659-7662
APOBEC3 proteins are restriction factors that induce G→A hypermutation in retroviruses during replication as a result of cytidine deamination of minus-strand DNA transcripts. However, the mechanism of APOBEC inhibition of murine leukemia viruses (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828532e99e4ef062218bce141afa1846
https://doi.org/10.1128/jvi.00967-14
https://doi.org/10.1128/jvi.00967-14
Autor:
Timothy J. Vyse, Kiyoaki Ito, Shozo Izui, Valérie Leroy, Leonard H. Evans, Masao Kihara, Lucie Clementine Baudino
Publikováno v:
Journal of autoimmunity
Endogenous retroviruses are implicated in murine lupus nephritis. They provide a source of nephritogenic retroviral gp70-anti-gp70 immune complexes through the production of serum gp70 protein and anti-gp70 autoantibodies as a result of the activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce0242f994dd6b5fa9ee2d2ee81d0c9c
https://doi.org/10.1016/j.jaut.2013.01.014
https://doi.org/10.1016/j.jaut.2013.01.014
Publikováno v:
Virology. 499
We have demonstrated in a mouse model that infection with a retrovirus can lead not only to the generation of recombinants between exogenous and endogenous gammaretrovirus, but also to the mobilization of endogenous proviruses by pseudotyping entire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25e8433119538b9f9983bc4b2bab9df
https://pubmed.ncbi.nlm.nih.gov/27657834
https://pubmed.ncbi.nlm.nih.gov/27657834
Autor:
Leonard H. Evans, Masao Kihara, Valérie Leroy, Lucie Clementine Baudino, Shozo Izui, Guy Brighouse
Publikováno v:
Journal of autoimmunity
The envelope glycoprotein, gp70, of endogenous retroviruses represents one of the major nephritogenic autoantigens implicated in murine systemic lupus erythematosus. Among different endogenous retroviruses (ecotropic, xenotropic and polytropic), lupu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0107cfaeae66250ba5ac0fb8e3442b
Autor:
Frank Malik, John L. Portis, Kyle Rosenke, Leonard H. Evans, Duncan Hendrick, Angelo Kolokithas, Kim J. Hasenkrug, Mario L. Santiago, Lukas Swanson
Publikováno v:
Journal of Virology. 84:10933-10936
APOBEC proteins have evolved as innate defenses against retroviral infections. Human immunodeficiency virus (HIV) encodes the Vif protein to evade human APOBEC3G; however, mouse retroviruses do not encode a Vif homologue, and it has not been understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cfc593285ced15489a895e5210bce1
https://doi.org/10.1128/jvi.01023-10
https://doi.org/10.1128/jvi.01023-10
Autor:
Trine N. Jørgensen, Naoki Morito, Liliane Fossati-Jimack, Lucie Clementine Baudino, Leonard H. Evans, Bernard J Morley, Shuichi Kikuchi, Timothy J. Vyse, Kumiko Yoshinobu, Sachiko Hirose, Brian L. Kotzin, Christina L. Roark, Rebecca M. Tucker, Shozo Izui
Publikováno v:
Journal of Immunology, Vol. 181, No 4 (2008) pp. 2846-54
The endogenous retroviral envelope glycoprotein, gp70, implicated in murine lupus nephritis is secreted by hepatocytes as an acute phase protein, and it has been thought to be a product of an endogenous xenotropic virus, NZB-X1. However, since endoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f150a229c8a7c19c4728d6b9707a5b56
https://doi.org/10.4049/jimmunol.181.4.2846
https://doi.org/10.4049/jimmunol.181.4.2846