Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leonard G. Contillo"'
Autor:
Mark J. Cole, Shawn Harriman, Sabrina X. Zhao, John R. Soglia, James G. Boyd, Leonard G. Contillo, John T. Barberia
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 36:105-116
An in vitro reactive intermediate screening assay, incorporating the use of the close analog of glutathione, glutathione ethyl ester (GSH-EE) as a conjugating agent, was developed to identify compounds that form reactive intermediates in an in vitro
Autor:
R. W. Stevenson, David K. Kreutter, S. J. Orena, A. J. Torchia, Leonard G. Contillo, Glenn C. Andrews
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 264:E606-E613
Amylin and calcitonin gene-related peptide (CGRP) inhibited insulin-stimulated 2-deoxyglucose uptake in L6 myocytes and isolated soleus muscle. Both peptides were maximally active at 10 pM in L6 cells and inhibited insulin action by 40-50%. In soleus
Autor:
Leonard G. Contillo
Publikováno v:
ChemInform. 40
We have developed a novel chromatography for the rapid isolation of active ribosomes from bacteria without the use of harsh conditions or lengthy procedures that damage ribosomes. Ribosomes interact with an alkyl linker attached to the resin, apparen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651d0653bc3ef6115fb68bb4b78f535d
https://europepmc.org/articles/PMC2151033/
https://europepmc.org/articles/PMC2151033/
Autor:
Leonard G. Contillo, Janice C. Parker, Ralph W. Stevenson, Glenn C. Andrews, Jane M. Withka, Walter W. Massefski, David H. Singleton, Kim M. Andrews
Publikováno v:
Peptides for the New Millennium ISBN: 0792364457
Glucagon-like peptide-1 (GLP-1) is an effective insulin secretagogue with sustained efficacy, with therapeutic potential in treating diabetes [1], As a result there has been much interest is determining its’ receptor bound conformation for rational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa67974d3f033e121416bd35eeac493
https://doi.org/10.1007/0-306-46881-6_267
https://doi.org/10.1007/0-306-46881-6_267
Autor:
Mark J. Cole, James G. Boyd, Cornelis E.C.A. Hop, Leonard G. Contillo, Amit S. Kalgutkar, John R. Soglia, Sabrina X. Zhao
Publikováno v:
Chemical research in toxicology. 19(3)
An in vitro semiquantitative reactive metabolite detection assay is described that incorporates NADPH-supplemented human liver microsomes, a novel quaternary ammonium glutathione analogue conjugating agent (QA-GSH), and liquid chromatography-tandem m
Autor:
Leonard G. Contillo, Kim M. Andrews, Walter W. Massefski, D.M. Rescek, Janice C. Parker, David H. Singleton, R W Stevenson, R.T. Suleske, Glenn C. Andrews
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 52(5)
We have used NMR in conjunction with measurements of functional bioactivity to define the receptor-binding structure of glucagon-like peptide-1 (GLP-1.) Identification of the important residues for binding was accomplished by the substitution of amin
Publikováno v:
Analytical biochemistry. 231(2)
Autor:
Gustav E. Lienhard, J J Herbst, E M Gibbs, David H. Singleton, P E Genereux, Leonard G. Contillo, Glenn C. Andrews
Publikováno v:
The Journal of biological chemistry. 270(43)
Insulin causes the activation of phosphatidylinositol 3-kinase (PI 3-kinase) through complexation of tyrosine-phosphorylated YMXM motifs on insulin receptor substrate 1 with the Src homology 2 domains of PI 3-kinase. Previous studies with inhibitors
Autor:
E M Gibbs, Glenn C. Andrews, Gardner J, Gustav E. Lienhard, Lamphere L, Leonard G. Contillo, Herbst Jj
Publikováno v:
Biochemistry. 33(32)
The phosphotyrosine form of the major substrate for the insulin receptor tyrosine kinase, insulin receptor substrate 1 (IRS-1), associates with and activates the enzyme phosphatidylinositol 3'-kinase (PtdIns 3'-kinase). IRS-1 contains nine potential