Zobrazeno 1 - 10
of 606
pro vyhledávání: '"Leonard G Gomella"'
Autor:
David Gonzalez, Joaquin Mateo, Albrecht Stenzinger, Federico Rojo, Michelle Shiller, Alexander W Wyatt, Frédérique Penault‐Llorca, Leonard G Gomella, Ros Eeles, Anders Bjartell
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 7, Iss 4, Pp 311-325 (2021)
Abstract Analysis of the genomic landscape of prostate cancer has identified different molecular subgroups with relevance for novel or existing targeted therapies. The recent approvals of the poly(ADP‐ribose) polymerase (PARP) inhibitors olaparib a
Externí odkaz:
https://doaj.org/article/6c8a0e9ecaee491db42b93bea2700669
Autor:
Matthew J Schiewer, Amy C Mandigo, Nicolas Gordon, Fangjin Huang, Sanchaika Gaur, Renée deLeeuw, Shuang G Zhao, Joseph Evans, Sumin Han, Theodore Parsons, Ruth Birbe, Peter McCue, Christopher McNair, Saswati N Chand, Ylenia Cendon‐Florez, Peter Gallagher, Jennifer J McCann, Neermala Poudel Neupane, Ayesha A Shafi, Emanuela Dylgjeri, Lucas J Brand, Tapio Visakorpi, Ganesh V Raj, Costas D Lallas, Edouard J Trabulsi, Leonard G Gomella, Adam P Dicker, Wm. Kevin Kelly, Benjamin E Leiby, Beatrice Knudsen, Felix Y Feng, Karen E Knudsen
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 12, Pp n/a-n/a (2018)
Abstract PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of P
Externí odkaz:
https://doaj.org/article/044d966fd25b4793a1abaa4247be3583
Autor:
Mathew Thakur, Vivek S. Tomar, Emma Dale, Leonard G. Gomella, Charalambos Solomides, Oleksandr Kolesnikov, Scott W. Keith, Hector T. Navarro, Olivia Dahlgren, Michael Chaga, Edouard J. Trabulsi
Publikováno v:
BJUI Compass, Vol 5, Iss 7, Pp 675-680 (2024)
Abstract Objectives The objective of this study is to validate a hypothesis that a non‐invasive optical imaging assay targeting genomic VPAC receptors on malignant cells shed in voided urine will represent either benign prostatic hyperplasia (BPH)
Externí odkaz:
https://doaj.org/article/eba6f254466f4e338bfd77aa902133bd
Autor:
Connor McPartland, Andrew Salib, Joshua Banks, James R. Mark, Costas D. Lallas, Edouard J. Trabulsi, Leonard G. Gomella, Hanan Goldberg, Benjamin Leiby, Robert Den, Thenappan Chandrasekar
Publikováno v:
European Urology Open Science, Vol 63, Iss , Pp 52-61 (2024)
Background and objective: Radiation therapy has increasingly been used in the management of pelvic malignancies. However, the use of radiation continues to pose a risk of a secondary malignancy to its recipients. This study investigates the risk of s
Externí odkaz:
https://doaj.org/article/8fed90a672d84d9b917cc404d3a1c1ed
Publikováno v:
Clinical Interventions in Aging, Vol Volume 5, Pp 187-197 (2010)
Jaspreet Singh , Edouard J Trabulsi, Leonard G GomellaDepartment of Urology Kimmel Cancer Center Thomas Jefferson University Philadelphia, PA, USAAbstract: Widespread screening with prostate-specific antigen (PSA) has led to a significant increase in
Externí odkaz:
https://doaj.org/article/93a5d75912924df8be875260bb5326b3
Autor:
Mark V Mishra, Michele Bennett, Armon Vincent, Olivia T Lee, Costas D Lallas, Edouard J Trabulsi, Leonard G Gomella, Adam P Dicker, Timothy N Showalter
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e68563 (2013)
Qualitative research aimed at identifying patient acceptance of active surveillance (AS) has been identified as a public health research priority. The primary objective of this study was to determine if analysis of a large-sample of anonymous interne
Externí odkaz:
https://doaj.org/article/e55631ed42984208a46b75d3a913e116
Autor:
Marco Genua, Shi-Qiong Xu, Simone Buraschi, Stephen C Peiper, Leonard G Gomella, Antonino Belfiore, Renato V Iozzo, Andrea Morrione
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40148 (2012)
The insulin-like growth factor receptor I (IGF-IR) plays an essential role in transformation by promoting cell growth and protecting cancer cells from apoptosis. We have recently demonstrated that the IGF-IR is overexpressed in invasive bladder cance
Externí odkaz:
https://doaj.org/article/534ece6ed05246f5946d372f7940c188
Autor:
Matteo Fassan, Domenico D'Arca, Juraj Letko, Andrea Vecchione, Marina P Gardiman, Peter McCue, Bernadette Wildemore, Massimo Rugge, Dolores Shupp-Byrne, Leonard G Gomella, Andrea Morrione, Renato V Iozzo, Raffaele Baffa
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19771 (2011)
MITOSTATIN, a novel putative tumor suppressor gene induced by decorin overexpression, is expressed in most normal human tissues but is markedly down-regulated in advanced stages of mammary and bladder carcinomas. Mitostatin negatively affects cell gr
Externí odkaz:
https://doaj.org/article/d9f46bfa256f446d8ff4893282fd87db
Autor:
Leonard G. Gomella
This book is an easily accessible reference guide for any practitioner encountering urologic symptoms or disease. It uses the famous two-page layout and outline format of The 5-Minute Consult Series. The book provides instant access to clinically-ori
The Oxford American Handbook of Urology provides authoritative, point-of-care guidance on all aspects of the field, covering both benign and malignant conditions, as well as medical and surgical management. Incorporating diagnosis and treatment advic