Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Leonard F Bjeldanes"'
Autor:
Sreenivasan Paruthiyil, Aleksandra Cvoro, Xiaoyue Zhao, Zhijin Wu, Yunxia Sui, Richard E Staub, Scott Baggett, Candice B Herber, Chandi Griffin, Mary Tagliaferri, Heather A Harris, Isaac Cohen, Leonard F Bjeldanes, Terence P Speed, Fred Schaufele, Dale C Leitman
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6271 (2009)
Estrogens produce biological effects by interacting with two estrogen receptors, ERalpha and ERbeta. Drugs that selectively target ERalpha or ERbeta might be safer for conditions that have been traditionally treated with non-selective estrogens. Seve
Externí odkaz:
https://doaj.org/article/ac45f5106f1c4ee9a8edf5000ecb05d8
Supplementary Methods, Figures 1-3 from Direct Inhibition of Elastase Activity by Indole-3-Carbinol Triggers a CD40-TRAF Regulatory Cascade That Disrupts NF-κB Transcriptional Activity in Human Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902eb8ac9df8e68ae0929e3c71717d2c
https://doi.org/10.1158/0008-5472.22382003.v1
https://doi.org/10.1158/0008-5472.22382003.v1
Treatment of highly tumorigenic MDA-MB-231 human breast cancer cells with indole-3-carbinol (I3C) directly inhibited the extracellular elastase-dependent cleavage of membrane-associated CD40, a member of the tumor necrosis factor (TNF) receptor super
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::710fd0688e0baae44e3bfd625e154d5e
https://doi.org/10.1158/0008-5472.c.6500063.v1
https://doi.org/10.1158/0008-5472.c.6500063.v1
Publikováno v:
The Journal of Nutritional Biochemistry. 24:1882-1888
3,3′-Diindolylmethane (DIM), an indole derivative from vegetables of the Brassica genus, has antiproliferative activity in breast cancer cells. Part of this activity is thought to be due to DIM inhibition of Akt signaling, but an upstream mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b23dc884dbaa6bd86a184e926aaa8a
https://doi.org/10.1016/j.jnutbio.2013.05.004
https://doi.org/10.1016/j.jnutbio.2013.05.004
Autor:
Puspa Dewi Lotulung, Nicholas Lorig-Roach, Haixia Chen, Muhammad Hanafi, Elizabeth A. Widjaja, Tanya L. Cohen, Leonard F. Bjeldanes, Ronaldo A. Pilli, Kyria Boundy-Mills, Tyler A. Johnson, Aidan E. Ward, Leonardus B.S. Kardono, Johann Sohn
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:4358-4364
An evaluation of Indonesian plants to identify compounds with immune modulating activity revealed that the methanolic extract of an Alphonsea javanica Scheff specimen possessed selective anti-inflammatory activity in a nuclear factor-kappa B (NF-κB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0138248c8560db10317c6f6ce3b59a6
https://doi.org/10.1016/j.bmc.2013.04.055
https://doi.org/10.1016/j.bmc.2013.04.055
Autor:
Henry Y. Yi, Chuangxing Ye, Jeffrey A. Simms, Leonard F. Bjeldanes, Rui Li, Selena E. Bartlett, Allison A. Feduccia, Yuanyuan Wang
Publikováno v:
Pharmacology Biochemistry and Behavior. 102:241-248
Purine compounds, such as caffeine, have many health-promoting properties and have proven to be beneficial in treating a number of different conditions. Theacrine, a purine alkaloid structurally similar to caffeine and abundantly present in Camellia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e33a2ff1bdc2b5f517bc7a846153595
https://doi.org/10.1016/j.pbb.2012.04.014
https://doi.org/10.1016/j.pbb.2012.04.014
Autor:
Arif Nukanto, Samarkand A. Estee, Karen Tenney, Atit Kanti, Joseline Ratnam, Johann Sohn, Heddy Julistiono, Yongchun Shen, Steven T. Loveridge, Nadine C. Gassner, Junke Liu, Helene C. Vervoort, Wayne D. Inman, Kyria Boundy-Mills, Leonard F. Bjeldanes, Leonardus B.S. Kardono, R. Scott Lokey, Tyler A. Johnson, Phillip Crews, Kenny K. H. Ang, James H. McKerrow, Walter M. Bray
Publikováno v:
Journal of Natural Products. 74:2545-2555
A high-throughput (HT) paradigm generating LC-MS-UV-ELSD-based natural product libraries to discover compounds with new bioactivities and or molecular structures is presented. To validate this methodology, an extract of the Indo-Pacific marine sponge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2b1905049179e78c628229123a536a
https://doi.org/10.1021/np200673b
https://doi.org/10.1021/np200673b
Autor:
Maria N. Preobrazhenskaya, Ida Aronchik, Marshall S. Horwitz, Leonard F. Bjeldanes, Tony J Chen, Gary L. Firestone, Kathleen A. Durkin
Publikováno v:
Molecular Carcinogenesis. 51:881-894
Elastase is the only currently identified target protein for indole-3-carbinol (I3C), a naturally occurring hydrolysis product of glucobrassicin in cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts that induces a cell cycle arres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc5e7d0fdc2ca91f536f0b4579f392f8
https://doi.org/10.1002/mc.20857
https://doi.org/10.1002/mc.20857
Autor:
Antony S. Tin, Shyam N. Sundar, Crystal N. Marconett, Gary L. Firestone, Leonard F. Bjeldanes, Min Tseng, Kelly M. Mahuron, Kalvin Q. Tran
Publikováno v:
Carcinogenesis. 32:1315-1323
Indole-3-carbinol (I3C), a naturally occurring hydrolysis product of glucobrassicin from cruciferous vegetables such as broccoli, cabbage and Brussels sprouts, is an anticancer phytochemical that triggers complementary sets of antiproliferative pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf048e254fc13d506fe02ea183a3547
https://doi.org/10.1093/carcin/bgr116
https://doi.org/10.1093/carcin/bgr116
Autor:
Quan-Xiang Wu, Johann Sohn, Mitchell S. Crews, Phillip Crews, Tyler A. Johnson, Marija Draskovic, Leonard F. Bjeldanes, Frederick A. Valeriote, Karen Tenney, Xiao-Jun Yao
Publikováno v:
Organic Letters. 12:4458-4461
Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c9f9098a91136add45611ca1f26240
https://doi.org/10.1021/ol101396n
https://doi.org/10.1021/ol101396n