Neutralizing the pathological effects of extracellular histones with small polyanions

Autor: Connor H. O’ Meara, Lucy A. Coupland, Farzaneh Kordbacheh, Benjamin J. C. Quah, Chih-Wei Chang, David A. Simon Davis, Anna Bezos, Anna M. Browne, Craig Freeman, Dillon J. Hammill, Pradeep Chopra, Gergely Pipa, Paul D. Madge, Esther Gallant, Courtney Segovis, Angela F. Dulhunty, Leonard F. Arnolda, Imogen Mitchell, Levon M. Khachigian, Ross W. Stephens, Mark von Itzstein, Christopher R. Parish

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Histones, proteins that bind DNA, are toxic for pathogens outside cells but can also cause multi-organ damage as seen in sepsis. Here the authors develop small negatively charged molecules that can be used as histone antidotes, and show that they imp

Externí odkaz: https://doaj.org/article/47652de3a653433fb4ea511fb90437ea

Marfan syndrome resulting from a rare pathogenic FBN1 variant, ascertained through a proband with IgG4 ‐related arteriopathy

Autor: Genevieve M. Gabb, Leonard F Arnolda, Peter H. Byers, Nadia Clare Wise, John P. Slavotinek, Steven A. J. Chamuleau, E. Haan, Dimuth N. Gunawardane, Francois H. Chamalaun, Ulrike Schwarze

Publikováno v: American journal of medical genetics. Part A, 185(7), 2180-2189. Wiley-Liss Inc.
American Journal of Medical Genetics, Part A, 185(7), 2180-2189. Wiley-Liss Inc.

A 57-year-old man with a family history of aortic aneurysm was found, during assessment of unexplained fever, to have an infrarenal aortic aneurysm requiring immediate repair. Dilatation of popliteal and iliac arteries was also present. Progressive a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed35e059e212588bf29cb99e338b0e7
https://doi.org/10.1002/ajmg.a.62218

Micro-CT scan with virtual dissection of left ventricle is a non-destructive, reproducible alternative to dissection and weighing for left ventricular size

Autor: Alejandra H Rangel, Quang Nguyen, Grant Morahan, A. Doost, Leonard F Arnolda

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports

Micro-CT scan images enhanced by iodine staining provide high-resolution visualisation of soft tissues in laboratory mice. We have compared Micro-CT scan-derived left ventricular (LV) mass with dissection and weighing. Ex-vivo micro-CT scan images of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbff035aa25050c6dc8b6698ab767204
http://link.springer.com/article/10.1038/s41598-020-70734-3

Autonomic Afferent Dysregulation in Atrial Fibrillation

Autor: Varun Malik, Adrian D. Elliott, Gijo Thomas, Ricardo S. Mishima, Bradley Pitman, Melissa E. Middeldorp, John L. Fitzgerald, Glenn D. Young, Kurt C. Roberts-Thomson, Leonard F. Arnolda, Dennis H. Lau, Prashanthan Sanders

Publikováno v: JACC. Clinical electrophysiology. 8(2)

This study sought to evaluate the role of cardiac afferent reflexes in atrial fibrillation (AF).Efferent autonomic tone is not associated with atrial remodeling and AF persistence. However, the role of cardiac afferents is unknown.Individuals with no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c006dabafbb177d1fac4adff4f35a710
https://pubmed.ncbi.nlm.nih.gov/35210072

70Autonomic dysfunction in atrial fibrillation (AF) patients: absent vasomotor reflex to decreased cardiac venous return during af in comparison to sinus rhythm; implications for earlier rhythm control

Autor: Dennis H. Lau, R. Mishima, Varun Malik, Adrian D. Elliott, Prashanthan Sanders, Mehrdad Emami, K Roberts-Thompson, Rajiv Mahajan, Leonard F Arnolda

Publikováno v: EP Europace. 22

Funding Acknowledgements Dr Malik is supported by an Australian Postgraduate Award Scholarship from the University of Adelaide. OnBehalf Centre for Heart Rhythm Disorders, University of Adelaide & Royal Adelaide Hospital Background A bi-directional r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d23567d37fa11882b449b0ed677b228
https://doi.org/10.1093/europace/euaa162.274