Výsledky vyhledávání - "Leonard E Estephan"

Akademický článek

Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell carcinoma

Autor: Leonard E. Estephan, Gaurav Kumar, Matthew Stewart, Raphael Banoub, Alban Linnenbach, Larry A. Harshyne, Ubaldo E. Martinez-Outschoorn, My G. Mahoney, Joseph M. Curry, Jennifer Johnson, Andrew P. South, Adam J. Luginbuhl

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionOral cavity squamous cell carcinoma (OSCC) occurs most frequently in patients >60 years old with a history of tobacco and alcohol use. Epidemiological studies describe increased incidence of OSCC in younger adults (

Externí odkaz: https://doaj.org/article/e9d45b677aae49609b52fa22b9ed27e2

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Akademický článek

Distinct plasma gradients of microRNA-204 in the pulmonary circulation of patients suffering from WHO Groups I and II pulmonary hypertension

Autor: Leonard E. Estephan, Michael V. Genuardi, Chad M. Kosanovich, Michael G. Risbano, Yingze Zhang, Nancy Petro, Annie Watson, Yassmin Al Aaraj, John C. Sembrat, Mauricio Rojas, Dmitry A. Goncharov, Marc A. Simon, Elena A. Goncharova, Anjali Vaidya, Akaya Smith, Jeremy Mazurek, Yuchi Han, Stephen Y. Chan

Publikováno v: Pulmonary Circulation, Vol 9 (2019)

Pulmonary hypertension (PH), a heterogeneous vascular disease, consists of subtypes with overlapping clinical phenotypes. MicroRNAs, small non-coding RNAs that negatively regulate gene expression, have emerged as regulators of PH pathogenesis. The mu

Externí odkaz: https://doaj.org/article/4c7d0f995d0946f1841a11d19b982e4f

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Total Intravenous Anesthesia Versus Inhaled Sevoflurane in Obstructive Sleep Apnea Surgery: A Randomized Controlled Trial

Autor: Leonard E. Estephan, Sarah Sussman, Matthew Stewart, Tingting Zhan, Adam Thaler, Maurits Boon, Patrick Hunt, Colin Huntley

Publikováno v: The LaryngoscopeBIBLIOGRAPHY.

Specific guidelines regarding an optimal general anesthesia (GA) approach to obstructive sleep apnea (OSA) patients remain undefined. Literature comparing the efficacy of total intravenous anesthesia (TIVA) and inhalational anesthesia in this populat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9786200488c02eea26a0f524173be9aa
https://pubmed.ncbi.nlm.nih.gov/36239660

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Matrix stiffening induces a pathogenic QKI-miR-7-SRSF1 signaling axis in pulmonary arterial endothelial cells

Autor: Leonard E Estephan, Ying Tang, Neha Hafeez, Seungchan Kim, Thomas Bertero, Stephen Y. Chan, Gil Speyer, Lloyd D. Harvey, Adam Handen, Chen-Shan Chen Woodcock

Publikováno v: Am J Physiol Lung Cell Mol Physiol
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2021, 320 (5), pp.L726-L738. ⟨10.1152/ajplung.00407.2020⟩

International audience; Pulmonary arterial hypertension (PAH) refers to a set of heterogeneous vascular diseases defined by elevation of pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR), leading to right ventricular (RV) remo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335edaad629d93fc4294f646055ba5cf
https://pubmed.ncbi.nlm.nih.gov/33565360

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Abstract 14698: Matrix Stiffening Induces a Pathogenic Qki-microrna-7-srsf1 Axis in Pulmonary Arterial Endothelial Cells

Autor: Gil Speyer, Neha Hafeez, Leonard E Estephan, Adam Handen, Thomas Bertero, Chen-shan J Woodcock, Stephen Y. Chan, Ying Tang, Seungchan Kim

Publikováno v: Circulation. 142

Introduction: Early increases in pulmonary artery stiffness drive pathogenic alterations of pulmonary arterial endothelial cells (PAECs), leading to vascular remodeling, a prominent feature of pulmonary hypertension (PH). However, the molecular mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66d0744b1df936a09756cec2d42d7686
https://doi.org/10.1161/circ.142.suppl_3.14698

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Reduced gastroesophageal reflux disease symptom severity following upper airway surgery for comorbid obstructive sleep apnea

Autor: Leonard E. Estephan, Angela Alnemri, Matthew Stewart, K. Arielle Best, Ashwin Ananth, Maurits Boon, Christina Tofani, Colin Huntley

Publikováno v: American Journal of Otolaryngology. 43:103340

To evaluate patient-reported quality of life pertaining to gastroesophageal reflux disease symptoms in patients undergoing upper airway surgery for comorbid obstructive sleep apnea.A prospective survey-based study was conducted on patients with gastr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe6b763f8214716f69b5ba367e67108
https://doi.org/10.1016/j.amjoto.2021.103340

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Specific circulating microRNAs display dose-dependent responses to variable intensity and duration of endurance exercise

Autor: Claire Lo, Leonard E Estephan, Ying Tang, Masataka Sugahara, Jingsi Zhao, Anna E. Ramos, Stephen Y. Chan, Aaron L. Baggish, Daniel E. Lieberman, Marcel Brown, John Gorcsan, Yi Yin Tai

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 315:H273-H283

Circulating microRNAs (c-miRNAs), plasma-based noncoding RNAs that control posttranscriptional gene expression, mediate processes that underlie phenotypical plasticity to exercise. The relationship and biological relevance between c-miRNA expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6903b64da1908ed34aeb36c6421a14
https://doi.org/10.1152/ajpheart.00741.2017

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Distinct plasma gradients of microRNA-204 in the pulmonary circulation of patients suffering from WHO Groups I and II pulmonary hypertension

Autor: Yassmin Al Aaraj, Yingze Zhang, Jeremy A. Mazurek, A. Smith, Anjali Vaidya, Michael V. Genuardi, Nancy Petro, John Sembrat, Dmitry A. Goncharov, Michael G. Risbano, Marc A. Simon, Annie M. Watson, Stephen Y. Chan, Elena A. Goncharova, Yuchi Han, Mauricio Rojas, Leonard E Estephan, Chad M. Kosanovich

Publikováno v: Pulmonary circulation, vol 9, iss 2
Pulmonary Circulation
Pulmonary Circulation, Vol 9 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26e6aa30d52e8ae22bbc8b2f21c9223
https://escholarship.org/uc/item/9d14r9sw

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