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pro vyhledávání: '"Leonard Ciccarelli"'
Autor:
Shuang Liang, Kathleen Haverty, Donghong Amy Gao, Jun Li, Xiang Li, Sabine Schlyer, Alexander Heim-Riether, Melissa Hill-Drzewi, Steven John Taylor, Steluta Mariana Margarit, Lana Louise Smith Keenan, Neil Moss, Nelamangala V. Nagaraja, Xianhua Cao, Dieter Wiedenmayer, Neil A. Farrow, Kyle E. Harrington, Brandon Collins, E. Michael August, Leonard Ciccarelli, Rene Roman, Bernd Wellenzohn, Zhaoming Xiong, Laura Amodeo, John R. Proudfoot
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(17)
SAR studies to improve the selectivity and metabolic stability of a class of recently discovered MMP-13 inhibitors are reported. Improved selectivity was achieved by modifying interactions with the S1' pocket. Metabolic stability was improved through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5361dabb2993b47e9d3285e7d2bb2c7
https://pubmed.ncbi.nlm.nih.gov/20675133
https://pubmed.ncbi.nlm.nih.gov/20675133
