Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Leonard C. Schalkwyk"'
Autor:
Eilis Hannon, Emma L. Dempster, Jonathan P. Davies, Barry Chioza, Georgina E. T. Blake, Joe Burrage, Stefania Policicchio, Alice Franklin, Emma M. Walker, Rosemary A. Bamford, Leonard C. Schalkwyk, Jonathan Mill
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Due to interindividual variation in the cellular composition of the human cortex, it is essential that covariates that capture these differences are included in epigenome-wide association studies using bulk tissue. As experimental
Externí odkaz:
https://doaj.org/article/3d312550f3bb4808b28fa6884c2ceea6
Autor:
Yucheng Wang, Eilis Hannon, Olivia A. Grant, Tyler J. Gorrie-Stone, Meena Kumari, Jonathan Mill, Xiaojun Zhai, Klaus D. McDonald-Maier, Leonard C. Schalkwyk
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Sex is an important covariate of epigenome-wide association studies due to its strong influence on DNA methylation patterns across numerous genomic positions. Nevertheless, many samples on the Gene Expression Omnibus (GEO) frequen
Externí odkaz:
https://doaj.org/article/a8b79469f0f543a68c7cafb40ffdb108
Autor:
Louis Y. El Khoury, Tyler Gorrie-Stone, Melissa Smart, Amanda Hughes, Yanchun Bao, Alexandria Andrayas, Joe Burrage, Eilis Hannon, Meena Kumari, Jonathan Mill, Leonard C. Schalkwyk
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments
Externí odkaz:
https://doaj.org/article/e6858c0976d94ec39b1624f1fc0daea6
Autor:
Ayden Saffari, Matt Arno, Eric Nasser, Angelica Ronald, Chloe C. Y. Wong, Leonard C. Schalkwyk, Jonathan Mill, Frank Dudbridge, Emma L. Meaburn
Publikováno v:
Molecular Autism, Vol 10, Iss 1, Pp 1-15 (2019)
Abstract Background A gap exists in our mechanistic understanding of how genetic and environmental risk factors converge at the molecular level to result in the emergence of autism symptoms. We compared blood-based gene expression signatures in ident
Externí odkaz:
https://doaj.org/article/0437b4b1c786481ea574790327c7c787
Autor:
Christopher G. Bell, Robert Lowe, Peter D. Adams, Andrea A. Baccarelli, Stephan Beck, Jordana T. Bell, Brock C. Christensen, Vadim N. Gladyshev, Bastiaan T. Heijmans, Steve Horvath, Trey Ideker, Jean-Pierre J. Issa, Karl T. Kelsey, Riccardo E. Marioni, Wolf Reik, Caroline L. Relton, Leonard C. Schalkwyk, Andrew E. Teschendorff, Wolfgang Wagner, Kang Zhang, Vardhman K. Rakyan
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-24 (2019)
Abstract Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive rese
Externí odkaz:
https://doaj.org/article/28a27bd480ce4e52b0b6b60f28afc126
Autor:
Heath E. O’Brien, Eilis Hannon, Matthew J. Hill, Carolina C. Toste, Matthew J. Robertson, Joanne E. Morgan, Gemma McLaughlin, Cathryn M. Lewis, Leonard C. Schalkwyk, Lynsey S. Hall, Antonio F. Pardiñas, Michael J. Owen, Michael C. O’Donovan, Jonathan Mill, Nicholas J. Bray
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Genetic influences on gene expression in the human fetal brain plausibly impact upon a variety of postnatal brain-related traits, including susceptibility to neuropsychiatric disorders. However, to date, there have been no studies
Externí odkaz:
https://doaj.org/article/451231d2d0294c8c87bcc47a19e30cea
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during human f
Externí odkaz:
https://doaj.org/article/c51974de697848c89ab7ed9b661fb8fc
Autor:
Lotte C. Houtepen, Christiaan H. Vinkers, Tania Carrillo-Roa, Marieke Hiemstra, Pol A. van Lier, Wim Meeus, Susan Branje, Christine M. Heim, Charles B. Nemeroff, Jonathan Mill, Leonard C. Schalkwyk, Menno P. Creyghton, René S. Kahn, Marian Joëls, Elisabeth B. Binder, Marco P. M. Boks
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Exposure to childhood trauma is a major risk factor for the development of almost all psychiatric disorders. By epigenome-wide studies, here, Houtepen et al. show that DNA methylation at a locus in the Kit ligand gene (KITLG) mediates the relationshi
Externí odkaz:
https://doaj.org/article/8d086f36e6654c299d12aa96eafaf3c5
Autor:
Marite Punapart, Mall Eltermaa, Julia Oflijan, Silva Sütt, Anne Must, Sulev Kõks, Leonard C. Schalkwyk, Catherine Fernandes, Eero Vasar, Ursel Soomets, Anton Terasmaa
Publikováno v:
PPAR Research, Vol 2014 (2014)
Valproic acid (VPA) is a widely used anticonvulsant and mood-stabilizing drug whose use is often associated with drug-induced weight gain. Treatment with VPA has been shown to upregulate Wfs1 expression in vitro. Aim of the present study was to compa
Externí odkaz:
https://doaj.org/article/a2cfd09662a04d48ad3bb711a9e2b95e
Autor:
Robert Flynn, Sam Washer, Aaron R Jeffries, Alexandria Andrayas, Gemma Shireby, Meena Kumari, Leonard C Schalkwyk, Jonathan Mill, Eilis Hannon
Publikováno v:
Human molecular genetics. 31(18)
Most epigenetic epidemiology to date has utilized microarrays to identify positions in the genome where variation in DNA methylation is associated with environmental exposures or disease. However, these profile less than 3% of DNA methylation sites i