Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Leonard C Schalkwyk"'
Autor:
Fredrika Åsenius, Tyler J Gorrie-Stone, Ama Brew, Yasmin Panchbhaya, Elizabeth Williamson, Leonard C Schalkwyk, Vardhman K Rakyan, Michelle L Holland, Sarah J Marzi, David J Williams
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009035 (2020)
Epidemiological research suggests that paternal obesity may increase the risk of fathering small for gestational age offspring. Studies in non-human mammals indicate that such associations could be mediated by DNA methylation changes in spermatozoa t
Externí odkaz:
https://doaj.org/article/4e7639db547f4dac8a0fb9dbae7c93a9
Autor:
Timothy R Powell, Peter McGuffin, Ursula M D'Souza, Sarah Cohen-Woods, Georgina M Hosang, Charlotte Martin, Keith Matthews, Richard K Day, Anne E Farmer, Katherine E Tansey, Leonard C Schalkwyk
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91076 (2014)
Mood disorders consist of two etiologically related, but distinctly treated illnesses, major depressive disorder (MDD) and bipolar disorder (BPD). These disorders share similarities in their clinical presentation, and thus show high rates of misdiagn
Externí odkaz:
https://doaj.org/article/05e55262d74241f9b1695826b694e935
Autor:
Eilis Hannon, Emma L. Dempster, Jonathan P. Davies, Barry Chioza, Georgina E. T. Blake, Joe Burrage, Stefania Policicchio, Alice Franklin, Emma M. Walker, Rosemary A. Bamford, Leonard C. Schalkwyk, Jonathan Mill
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Due to interindividual variation in the cellular composition of the human cortex, it is essential that covariates that capture these differences are included in epigenome-wide association studies using bulk tissue. As experimental
Externí odkaz:
https://doaj.org/article/3d312550f3bb4808b28fa6884c2ceea6
Autor:
Margit eLill, Pille eTaba, Sulev eKõks, Ursel eSoomets, Irja eLutsar, Leonard C Schalkwyk, Cathy eFernandes
Publikováno v:
Frontiers in Neuroscience, Vol 7 (2013)
The aim of present study was to find genetic pathways activated during infection with bacterial meningitis (BM) and potentially influencing the course of the infection using genome-wide RNA expression profiling combined with pathway analysis and func
Externí odkaz:
https://doaj.org/article/efae2f0493cd4a3dbfff781fdde60828
Autor:
Robert Keers, Inti Pedroso, Gerome Breen, Kathy J Aitchison, Patrick M Nolan, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Leonard C Schalkwyk, Cathy Fernandes
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38263 (2012)
Disruption of the circadian rhythm is a key feature of bipolar disorder. Variation in genes encoding components of the molecular circadian clock has been associated with increased risk of the disorder in clinical populations. Similarly in animal mode
Externí odkaz:
https://doaj.org/article/7016b763792444098cf9b53b590806d9
Autor:
Rupert W Overall, Gerd Kempermann, Jeremy Peirce, Lu Lu, Dan Goldowitz, Fred H Gage, Shirlean Goodwin, August B Smit, David C Airey, Glenn D Rosen, Leonard C Schalkwyk, Thomas R Sutter, Richard S. Nowakowski, Stephen Whatley, Robert W Williams
Publikováno v:
Frontiers in Neuroscience, Vol 3 (2009)
Differences in gene expression in the CNS influence behavior and disease susceptibility. To systematically explore the role of normal variation in expression on hippocampal structure and function, we generated an online microarray database for a dive
Externí odkaz:
https://doaj.org/article/63fcd0ddcbaa412dbdaba773d2c7d34f
Autor:
Matthew N Davies, Sarah Lawn, Steven Whatley, Cathy Fernandes, Robert W Williams, Leonard C Schalkwyk
Publikováno v:
Frontiers in Neuroscience, Vol 3 (2009)
Microarrays are designed to measure genome-wide differences in gene expression. In cases where a tissue is not accessible for analysis (e.g. human brain), it is of interest to determine whether a second, accessible tissue could be used as a surrogate
Externí odkaz:
https://doaj.org/article/cf4bcbebc7a44acdb8c7c0f9c23c5de7
Autor:
Rebecca G Smith, Rachel L Kember, Jonathan Mill, Cathy Fernandes, Leonard C Schalkwyk, Joseph D Buxbaum, Abraham Reichenberg
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8456 (2009)
BACKGROUND: Accumulating evidence from epidemiological research has demonstrated an association between advanced paternal age and risk for several psychiatric disorders including autism, schizophrenia and early-onset bipolar disorder. In order to est
Externí odkaz:
https://doaj.org/article/b99335b2cadc4f55a7adedc93885ba15
Autor:
Robert Flynn, Sam Washer, Aaron R Jeffries, Alexandria Andrayas, Gemma Shireby, Meena Kumari, Leonard C Schalkwyk, Jonathan Mill, Eilis Hannon
Publikováno v:
Human molecular genetics. 31(18)
Most epigenetic epidemiology to date has utilized microarrays to identify positions in the genome where variation in DNA methylation is associated with environmental exposures or disease. However, these profile less than 3% of DNA methylation sites i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75d734d9ca0e3c6ab0f85aa9ba0680d
https://pubmed.ncbi.nlm.nih.gov/35567415
https://pubmed.ncbi.nlm.nih.gov/35567415
Autor:
T.J. Gorrie-Stone, Andrayas Ad, Xiaojun Zhai, Leonard C. Schalkwyk, Olivia A Grant, Yucheng Wang, Klaus D. McDonald-Maier
MotivationData normalization is an essential step to reduce technical variation within and between arrays. Due to the different karyotypes and the effects of X chromosome inactivation, females and males exhibit distinct methylation patterns on sex ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::810c117a1d75cabea4e891d545124fa3
https://doi.org/10.1101/2021.09.30.462546
https://doi.org/10.1101/2021.09.30.462546
