Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Leonard B. Maggi"'
Autor:
Vanessa Oliveira, Nitin Mahajan, Melissa L. Bates, Chakrapani Tripathi, Kyusik Q. Kim, Hani S. Zaher, Leonard B. Maggi Jr, Michael H. Tomasson
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 7, Pp 404-414 (2019)
Abstract The orphan small nucleolar RNA (snoRNA) ACA11 is overexpressed as a result of the t(4;14) chromosomal translocation in multiple myeloma (MM), increases reactive oxygen species, and drives cell proliferation. Like other snoRNAs, ACA11 is pred
Externí odkaz:
https://doaj.org/article/2c20f4e656694a63b1229336ad7e548f
Autor:
Alex H. Wagner, Siddhartha Devarakonda, Zachary L. Skidmore, Kilannin Krysiak, Avinash Ramu, Lee Trani, Jason Kunisaki, Ashiq Masood, Saiama N. Waqar, Nicholas C. Spies, Daniel Morgensztern, Jason Waligorski, Jennifer Ponce, Robert S. Fulton, Leonard B. Maggi, Jason D. Weber, Mark A. Watson, Christopher J. O’Conor, Jon H. Ritter, Rachelle R. Olsen, Haixia Cheng, Anandaroop Mukhopadhyay, Ismail Can, Melissa H. Cessna, Trudy G. Oliver, Elaine R. Mardis, Richard K. Wilson, Malachi Griffith, Obi L. Griffith, Ramaswamy Govindan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Small cell lung cancer (SCLC) patients frequently relapse and become resistant to chemotherapy. Here, the authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that act
Externí odkaz:
https://doaj.org/article/633460ab94c74c7ba9529694b90819e7
Autor:
Jing Qiu, Matteo Villa, David E. Sanin, Michael D. Buck, David O’Sullivan, Reagan Ching, Mai Matsushita, Katarzyna M. Grzes, Frances Winkler, Chih-Hao Chang, Jonathan D. Curtis, Ryan L. Kyle, Nikki Van Teijlingen Bakker, Mauro Corrado, Fabian Haessler, Francesca Alfei, Joy Edwards-Hicks, Leonard B. Maggi, Jr., Dietmar Zehn, Takeshi Egawa, Bertram Bengsch, Ramon I. Klein Geltink, Thomas Jenuwein, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2063-2074.e5 (2019)
Summary: Competition for nutrients like glucose can metabolically restrict T cells and contribute to their hyporesponsiveness during cancer. Metabolic adaptation to the surrounding microenvironment is therefore key for maintaining appropriate cell fu
Externí odkaz:
https://doaj.org/article/4ea68f59d3e14e4bbf5687d54711cf4f
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years
Externí odkaz:
https://doaj.org/article/e91137ce2f7747c3875ec60fa2250a89
Autor:
Jason T. Forys, Catherine E. Kuzmicki, Anthony J. Saporita, Crystal L. Winkeler, Leonard B. Maggi, Jr., Jason D. Weber
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 514-526 (2014)
Summary: The ARF and p53 tumor suppressors are thought to act in a linear pathway to prevent cellular transformation in response to various oncogenic signals. Here, we show that loss of p53 leads to an increase in ARF protein levels, which function t
Externí odkaz:
https://doaj.org/article/eaa17c2fcc3c482b9fcfd53d0e85ad7e
Autor:
Che-Pei Kung, Emily A. Bross, Catherine E. Kuzmicki, Michael Benjamin, Leonard B. Maggi, Jason D. Weber
Publikováno v:
Journal of Clinical and Translational Science, Vol 2, Pp 34-34 (2018)
OBJECTIVES/SPECIFIC AIMS: Triple-negative breast cancer (TNBC) accounts for one-fifth of the breast cancer patient population. The heterogeneous nature of TNBC and lack of options for targeted therapy make its treatment a constant adventure. The defi
Externí odkaz:
https://doaj.org/article/0ab77ba060ee4ba0ad0038e0a0583d8d
Autor:
Thwisha Sabloak, Emily R. Bramel, Catherine Kuzmicki, Eric Freeman, Jason D. Weber, Leonard B. Maggi, Sua Ryu, Emily A. Bross, Che-Pei Kung
Publikováno v:
Cancer Research. 80:P4-08
Research Overview and Objective Triple-negative breast cancer (TNBC) accounts for one-fifth of the breast cancer patient population. The heterogeneous nature of TNBC and lack of options for targeted therapy make its treatment a constant challenge. Th
Autor:
Kyusik Q. Kim, Leonard B. Maggi, Michael H. Tomasson, Melissa L. Bates, Vanessa De Oliveira, Hani S. Zaher, Chakrapani Tripathi, Nitin Mahajan
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 7, Pp 404-414 (2019)
FASEB bioAdvances
FASEB bioAdvances
The orphan small nucleolar RNA (snoRNA) ACA11 is overexpressed as a result of the t(4;14) chromosomal translocation in multiple myeloma (MM), increases reactive oxygen species, and drives cell proliferation. Like other snoRNAs, ACA11 is predominantly
Autor:
Leonard B. Maggi, Alison L. Antes
Publikováno v:
Curr Protoc
Researchers must conduct research responsibly for it to have an impact and to safeguard trust in science. Essential responsibilities of researchers include using rigorous, reproducible research methods, reporting findings in a trustworthy manner, and
Autor:
Leonard B. Maggi, Alison L. Antes
Publikováno v:
Curr Protoc
Relationships with mentors and labmates are defining aspects of a researcher's journey in science. Ideally, these interactions are outstanding opportunities to learn from others and provide the basis for lifelong collaborations. Unfortunately, someti