Diversity oriented biosynthesis via accelerated evolution of modular gene clusters

Autor: Aleksandra Wlodek, Steve G. Kendrew, Nigel J. Coates, Adam Hold, Joanna Pogwizd, Steven Rudder, Lesley S. Sheehan, Sarah J. Higginbotham, Anna E. Stanley-Smith, Tony Warneck, Mohammad Nur-E-Alam, Markus Radzom, Christine J. Martin, Lois Overvoorde, Markiyan Samborskyy, Silke Alt, Daniel Heine, Guy T. Carter, Edmund I. Graziani, Frank E. Koehn, Leonard McDonald, Alexander Alanine, Rosa María Rodríguez Sarmiento, Suzan Keen Chao, Hasane Ratni, Lucinda Steward, Isobel H. Norville, Mitali Sarkar-Tyson, Steven J. Moss, Peter F. Leadlay, Barrie Wilkinson, Matthew A. Gregory

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Reengineering polyketide synthase encoding genes to produce analogues of natural products can be slow and low-yielding. Here the authors use accelerated evolution to recombine the gene cluster for rapid production of rapamycin-related products.

Externí odkaz: https://doaj.org/article/b36ef21246ab47bfb8cbd4e969caea7c

Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation

Autor: Edward H. Kerns, Eric I. Rossman, Leonard McDonald, James K. Hennan, Qiang Wang, Bjarne Due Larsen, Christine Huselton, Li Di, John A. Butera, Kun Liu, Jørgen Søøøøøberg Petersen, Asaf Alimardanov, Gwen A. Morgan, Rayomand Unwalla, Robert E. Swillo

Publikováno v: Journal of medicinal chemistry. 52(4)

Rotigaptide (3) is an antiarrhythmic peptide that improves cardiac conduction by modifying gap-junction communication. Small molecule gap-junction modifiers with improved physical properties were identified from a Zealand Pharma peptide library using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566ea6a7cc1a58626de0e37de647e136
https://pubmed.ncbi.nlm.nih.gov/19175320

Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery—Building chiral technology toolboxesIn contrast to previous usage, Chiral Technology is defined in this review as the use of techniques or tools for the determination of absolute stereochemistry, the chiral analysis or preparative separation of racemic small molecules containing one or more asymmetric centers into (all of) their enantiomers (= enantiomeric or chiral separation), and the facilitation of asymmetric transformations, but not asymmetric transformations themselves. The terms Chiral Technology and Chirotechnology have often been used as a general category for asymmetric transformations using enzymes, chiral building blocks, chiral auxiliaries, and chiral catalysts, as well as chiral salt resolution.1–13

Autor: Oliver McConnell, Alvin Bach, Carl Balibar, Neal Byrne, Yanxuan Cai, Guy Carter, Michael Chlenov, Li Di, Kristi Fan, Igor Goljer, Yanan He, Don Herold, Michael Kagan, Edward Kerns, Frank Koehn, Christina Kraml, Vasilios Marathias, Brian Marquez, Leonard McDonald, Lisa Nogle

Publikováno v: Chirality; Sep2007, Vol. 19 Issue 9, p658-682, 25p

Provider caseload volume and short-term outcomes following colorectal surgeries in New Brunswick: a provincial-level cohort study.

Autor: Crouse DL; From the Department of Sociology, University of New Brunswick, Fredericton, N.B. (Crouse); the New Brunswick Institute for Research, Data and Training, University of New Brunswick, Fredericton, N.B. (Crouse, Boudreau, Leonard, McDonald); the Department of Economics, University of New Brunswick, Fredericton, N.B. (Leonard, McDonald); and the Faculty of Medicine, Dalhousie University, Halifax, N.S. (Pawluk)., Boudreau J; From the Department of Sociology, University of New Brunswick, Fredericton, N.B. (Crouse); the New Brunswick Institute for Research, Data and Training, University of New Brunswick, Fredericton, N.B. (Crouse, Boudreau, Leonard, McDonald); the Department of Economics, University of New Brunswick, Fredericton, N.B. (Leonard, McDonald); and the Faculty of Medicine, Dalhousie University, Halifax, N.S. (Pawluk)., Leonard PSJ; From the Department of Sociology, University of New Brunswick, Fredericton, N.B. (Crouse); the New Brunswick Institute for Research, Data and Training, University of New Brunswick, Fredericton, N.B. (Crouse, Boudreau, Leonard, McDonald); the Department of Economics, University of New Brunswick, Fredericton, N.B. (Leonard, McDonald); and the Faculty of Medicine, Dalhousie University, Halifax, N.S. (Pawluk)., Pawluk K; From the Department of Sociology, University of New Brunswick, Fredericton, N.B. (Crouse); the New Brunswick Institute for Research, Data and Training, University of New Brunswick, Fredericton, N.B. (Crouse, Boudreau, Leonard, McDonald); the Department of Economics, University of New Brunswick, Fredericton, N.B. (Leonard, McDonald); and the Faculty of Medicine, Dalhousie University, Halifax, N.S. (Pawluk)., McDonald JT; From the Department of Sociology, University of New Brunswick, Fredericton, N.B. (Crouse); the New Brunswick Institute for Research, Data and Training, University of New Brunswick, Fredericton, N.B. (Crouse, Boudreau, Leonard, McDonald); the Department of Economics, University of New Brunswick, Fredericton, N.B. (Leonard, McDonald); and the Faculty of Medicine, Dalhousie University, Halifax, N.S. (Pawluk).

Publikováno v: Canadian journal of surgery. Journal canadien de chirurgie [Can J Surg] 2020 Sep-Oct; Vol. 63 (5), pp. E475-E482.