Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Leona W, Serrano"'
Autor:
Lindsey Weed, Michael J. Ammar, Shangzhen Zhou, Zhangyong Wei, Leona W. Serrano, Junwei Sun, Vivian Lee, Albert M. Maguire, Jean Bennett, Tomas S. Aleman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 133-148 (2019)
We have demonstrated safe and effective subretinal readministration of recombinant adeno-associated virus serotype (rAAV) to the contralateral eye in large animals and humans even in the setting of preexisting neutralizing antibodies (NAbs). Readmini
Externí odkaz:
https://doaj.org/article/a83eb956e4fb4484b66b524d19d62ab4
Autor:
Tomas S. Aleman, Rachel M. Huckfeldt, Leona W. Serrano, Denise J. Pearson, Grace K. Vergilio, Sarah McCague, Kathleen A. Marshall, Manzar Ashtari, Tu M. Doan, Carol A. Weigel-DiFranco, Bethany S. Biron, Xiao-Hong Wen, Daniel C. Chung, Emily Liu, Kevin Ferenchak, Jessica I.W. Morgan, Eric A. Pierce, Dean Eliott, Jean Bennett, Jason Comander, Albert M. Maguire
Publikováno v:
Ophthalmology. 129:1177-1191
Autor:
Emma Bedoukian, Katherine E. Uyhazi, Leona W. Serrano, Jessica I. W. Morgan, Robert F. Cooper, Michael J. Ammar, Priyanka Kumar, Kurt T. Scavelli, Ilaina D. Edelstein, Tomas S. Aleman, Grace Vergilio
Publikováno v:
Retin Cases Brief Rep
PURPOSE: To describe in detail the phenotype of a patient with enhanced S-cone syndrome. METHODS: We describe a 13-year-old boy who presented with blurred vision, vitreous cells, cystoid macular edema refractory to steroid treatment, and a negative u
Autor:
Alexander Miller, Jean Bennett, Albert M. Maguire, Tomas S. Aleman, Bart P. Leroy, Keli O'Connor, Elena M. Aleman, Leona W. Serrano, Katherine H Maguire, Emma Bedoukian
Publikováno v:
Clinical Ophthalmology (Auckland, N.Z.)
CLINICAL OPHTHALMOLOGY
CLINICAL OPHTHALMOLOGY
Tomas S Aleman,1– 3 Alexander J Miller,4 Katherine H Maguire,1,2 Elena M Aleman,2 Leona W Serrano,1,2 Keli B O’Connor,1,2 Emma C Bedoukian,5 Bart P Leroy,3,6– 8 Albert M Maguire,1– 3 Jean Bennett1,2 1Scheie Eye Institute at the Perelman Cente
Publikováno v:
RETINAL Cases & Brief Reports. 16:385-392
PURPOSE To describe in detail the phenotype of two siblings with biallelic NMNAT1 mutations. METHODS A 4-year-old male patient (P1) and his 7-year-old sister (P2), product of a nonconsanguineous union of Egyptian ancestry, underwent a comprehensive o
Autor:
Zhangyong Wei, Michael J. Ammar, Vivian S. Lee, Tomas S. Aleman, Shangzhen Zhou, Lindsey Weed, Junwei Sun, Albert M. Maguire, Jean Bennett, Leona W. Serrano
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss, Pp 133-148 (2019)
We have demonstrated safe and effective subretinal readministration of recombinant adeno-associated virus serotype (rAAV) to the contralateral eye in large animals and humans even in the setting of preexisting neutralizing antibodies (NAbs). Readmini
Autor:
Tomas S, Aleman, Rachel M, Huckfeldt, Leona W, Serrano, Denise J, Pearson, Grace K, Vergilio, Sarah, McCague, Kathleen A, Marshall, Manzar, Ashtari, Tu M, Doan, Carol A, Weigel-DiFranco, Bethany S, Biron, Xiao-Hong, Wen, Daniel C, Chung, Emily, Liu, Kevin, Ferenchak, Jessica I W, Morgan, Eric A, Pierce, Dean, Eliott, Jean, Bennett, Jason, Comander, Albert M, Maguire
Publikováno v:
Ophthalmology. 129(10)
To assess the safety of the subretinal delivery of a recombinant adeno-associated virus serotype 2 (AAV2) vector carrying a human choroideremia (CHM)-encoding cDNA in CHM.Prospective, open-label, nonrandomized, dose-escalation, phase I/II clinical tr
Autor:
Tomas S. Aleman, Jessica I. W. Morgan, Denise J. Pearson, Grace Vergilio, Albert M. Maguire, Yu You Jiang, Leona W. Serrano, Jean Bennett
Subretinal injection for gene augmentation in retinal degenerations forcefully detaches the neural retina from the retinal pigment epithelium (RPE), potentially damaging photoreceptors and/or RPE cells. Here, we use adaptive optics scanning light oph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ae24a1c12ce096e422fcdb842b41ba8
https://doi.org/10.1101/2021.09.17.459817
https://doi.org/10.1101/2021.09.17.459817
Autor:
Jean Bennett, Leona W. Serrano, Drew Scoles, Grace K. Han, Kayla E Cunningham, Tomas S. Aleman, Erin C O'Neil, John Chiang
Publikováno v:
Ophthalmic Genetics. 40:267-275
Purpose: To confirm the pathogenic role of a novel mutation in PNPLA6 and detail the phenotype of a patient presenting with choroideremia-like chorioretinal degeneration. Methods: A 40-year-old man with presumed choroideremia underwent a complete oph
Autor:
Ivan Shpylchak, Vidyullatha Vasireddy, Katherine E. Uyhazi, Denise J. Pearson, Zhangyong Wei, Jean Bennett, Lanfranco Leo, Leona W. Serrano, Puya Aravand, Tomas S. Aleman, Brent A. Bell, Jennifer Pham
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To determine the therapeutic window for gene augmentation for Leber congenital amaurosis (LCA) associated with mutations in LCA5. Methods Five patients (ages 6-31) with LCA and biallelic LCA5 mutations underwent an ophthalmic examination incl